Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease von Kwak, Sang Su, Washicosky, Kevin J., Brand, Emma, von Maydell, Djuna, Aronson, Jenna, Kim, Susan, Capen, Diane E., Cetinbas, Murat, Sadreyev, Ruslan, Ning, Shen, Bylykbashi, Enjana, Xia, Weiming, Wagner, Steven L., Choi, Se Hoon, Tanzi, Rudolph E., Kim, Doo Yeon

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STIM1, an essential and conserved component of store-operated Ca²⁺ channel function von Roos, Jack, DiGregorio, Paul J, Yeromin, Andriy V, Ohlsen, Kari, Lioudyno, Maria, Zhang, Shenyuan, Safrina, Olga, Kozak, J. Ashot, Wagner, Steven L, Cahalan, Michael D, Veliçelebi, Gönůl, Stauderman, Kenneth A

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Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE von Bertram, Lars, Lange, Christoph, Mullin, Kristina, Parkinson, Michele, Hsiao, Monica, Hogan, Meghan F., Schjeide, Brit M.M., Hooli, Basavaraj, DiVito, Jason, Ionita, Iuliana, Jiang, Hongyu, Laird, Nan, Moscarillo, Thomas, Ohlsen, Kari L., Elliott, Kathryn, Wang, Xin, Hu-Lince, Diane, Ryder, Marie, Murphy, Amy, Wagner, Steven L., Blacker, Deborah, Becker, K. David, Tanzi, Rudolph E.

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Transcriptomic profiling of sporadic Alzheimer's disease patients von Caldwell, Andrew B, Anantharaman, Balaji G, Ramachandran, Srinivasan, Nguyen, Phuong, Liu, Qing, Trinh, Ivy, Galasko, Douglas R, Desplats, Paula A, Wagner, Steven L, Subramaniam, Shankar

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APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model von Deyts, Carole, Clutter, Mary, Pierce, Nicholas, Chakrabarty, Paramita, Ladd, Thomas B., Goddi, Anna, Rosario, Awilda M., Cruz, Pedro, Vetrivel, Kulandaivelu, Wagner, Steven L., Thinakaran, Gopal, Golde, Todd E., Parent, Angèle T.

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A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP von Weissmiller, April M, Natera-Naranjo, Orlangie, Reyna, Sol M, Pearn, Matthew L, Zhao, Xiaobei, Nguyen, Phuong, Cheng, Soan, Goldstein, Lawrence S B, Tanzi, Rudolph E, Wagner, Steven L, Mobley, William C, Wu, Chengbiao

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PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease von Perrin, Florian, Anderson, Lauren C, Mitchell, Shane P C, Sinha, Priyanka, Turchyna, Yuliia, Maesako, Masato, Houser, Mei C Q, Zhang, Can, Wagner, Steven L, Tanzi, Rudolph E, Berezovska, Oksana

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Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway von Das, Utpal, Wang, Lina, Ganguly, Archan, Saikia, Junmi M, Wagner, Steven L, Koo, Edward H, Roy, Subhojit

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A three-dimensional human neural cell culture model of Alzheimer’s disease von Choi, Se Hoon, Kim, Young Hye, Hebisch, Matthias, Sliwinski, Christopher, Lee, Seungkyu, D’Avanzo, Carla, Chen, Hechao, Hooli, Basavaraj, Asselin, Caroline, Muffat, Julien, Klee, Justin B., Zhang, Can, Wainger, Brian J., Peitz, Michael, Kovacs, Dora M., Woolf, Clifford J., Wagner, Steven L., Tanzi, Rudolph E., Kim, Doo Yeon

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons von van der Kant, Rik, Langness, Vanessa F., Herrera, Cheryl M., Williams, Daniel A., Fong, Lauren K., Leestemaker, Yves, Steenvoorden, Evelyne, Rynearson, Kevin D., Brouwers, Jos F., Helms, J. Bernd, Ovaa, Huib, Giera, Martin, Wagner, Steven L., Bang, Anne G., Goldstein, Lawrence S.B.

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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention von Rynearson, Kevin D, Ponnusamy, Moorthi, Prikhodko, Olga, Xie, Yuhuan, Zhang, Can, Nguyen, Phuong, Hug, Brenda, Sawa, Mariko, Becker, Ann, Spencer, Brian, Florio, Jazmin, Mante, Michael, Salehi, Bahar, Arias, Carlos, Galasko, Douglas, Head, Brian P, Johnson, Graham, Lin, Jiunn H, Duddy, Steven K, Rissman, Robert A, Mobley, William C, Thinakaran, Gopal, Tanzi, Rudolph E, Wagner, Steven L

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Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1 von Raven, Frank, Ward, Joseph F., Zoltowska, Katarzyna M., Wan, Yu, Bylykbashi, Enjana, Miller, Sean J., Shen, Xunuo, Choi, Se Hoon, Rynearson, Kevin D., Berezovska, Oksana, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can

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And four equals one: Presenilin takes the γ-secretase role by itself von Lessard, Christian B., Wagner, Steven L., Koo, Edward H.

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Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase von Jankowsky, Joanna L., Fadale, Daniel J., Anderson, Jeffrey, Xu, Guilian M., Gonzales, Victoria, Jenkins, Nancy A., Copeland, Neal G., Lee, Michael K., Younkin, Linda H., Wagner, Steven L., Younkin, Steven G., Borchelt, David R.

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ATP Effects on Insulin-degrading Enzyme Are Mediated Primarily through Its Triphosphate Moiety von Song, Eun Suk, Juliano, Maria Aparecida, Juliano, Luiz, Fried, Michael G., Wagner, Steven L., Hersh, Louis B.

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Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease von Kounnas, Maria Z., Danks, Anne M., Cheng, Soan, Tyree, Curtis, Ackerman, Elizabeth, Zhang, Xulun, Ahn, Kwangwook, Nguyen, Phuong, Comer, Dan, Mao, Long, Yu, Chengzhi, Pleynet, David, Digregorio, Paul J., Velicelebi, Gonul, Stauderman, Kenneth A., Comer, William T., Mobley, William C., Li, Yue-Ming, Sisodia, Sangram S., Tanzi, Rudolph E., Wagner, Steven L.

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Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers von Liu, Qing, Waltz, Shannon, Woodruff, Grace, Ouyang, Joe, Israel, Mason A, Herrera, Cheryl, Sarsoza, Floyd, Tanzi, Rudolph E, Koo, Edward H, Ringman, John M, Goldstein, Lawrence S. B, Wagner, Steven L, Yuan, Shauna H

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Reduction of the expression of the late-onset Alzheimer’s disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model von Andrew, Robert J., De Rossi, Pierre, Nguyen, Phuong, Kowalski, Haley R., Recupero, Aleksandra J., Guerbette, Thomas, Krause, Sofia V., Rice, Richard C., Laury-Kleintop, Lisa, Wagner, Steven L., Thinakaran, Gopal

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Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease von Andrew, Robert J., Fernandez, Celia G., Stanley, Molly, Jiang, Hong, Nguyen, Phuong, Rice, Richard C., Buggia-Prévot, Virginie, De Rossi, Pierre, Vetrivel, Kulandaivelu S., Lamb, Raza, Argemi, Arnau, Allaert, Emilie S., Rathbun, Elle M., Krause, Sofia V., Wagner, Steven L., Parent, Angèle T., Holtzman, David M., Thinakaran, Gopal

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Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates von Xu, Yulong, Wang, Changning, Wey, Hsiao-Ying, Liang, Yingxia, Chen, Zude, Choi, Se Hoon, Ran, Chongzhao, Rynearson, Kevin D, Bernales, Daniela R, Koegel, Robert E, Fiedler, Stephanie A, Striar, Robin, Wagner, Steven L, Tanzi, Rudolph E, Zhang, Can

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