Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19 von Hoffman, Robert L, Kania, Robert S, Brothers, Mary A, Davies, Jay F, Ferre, Rose A, Gajiwala, Ketan S, He, Mingying, Hogan, Robert J, Kozminski, Kirk, Li, Lilian Y, Lockner, Jonathan W, Lou, Jihong, Marra, Michelle T, Mitchell, Lennert J, Murray, Brion W, Nieman, James A, Noell, Stephen, Planken, Simon P, Rowe, Thomas, Ryan, Kevin, Smith, George J, Solowiej, James E, Steppan, Claire M, Taggart, Barbara

Volltext

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants von Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.

Volltext

Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools von Wiedmer, Tabea, Ingles‐Prieto, Alvaro, Goldmann, Ulrich, Steppan, Claire M., Superti‐Furga, Giulio

Volltext

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19 von Owen, Dafydd R., Allerton, Charlotte M. N., Anderson, Annaliesa S., Aschenbrenner, Lisa, Avery, Melissa, Berritt, Simon, Boras, Britton, Cardin, Rhonda D., Carlo, Anthony, Coffman, Karen J., Dantonio, Alyssa, Di, Li, Eng, Heather, Ferre, RoseAnn, Gajiwala, Ketan S., Gibson, Scott A., Greasley, Samantha E., Hurst, Brett L., Kadar, Eugene P., Kalgutkar, Amit S., Lee, Jack C., Lee, Jisun, Liu, Wei, Mason, Stephen W., Noell, Stephen, Novak, Jonathan J., Obach, R. Scott, Ogilvie, Kevin, Patel, Nandini C., Pettersson, Martin, Rai, Devendra K., Reese, Matthew R., Sammons, Matthew F., Sathish, Jean G., Singh, Ravi Shankar P., Steppan, Claire M., Stewart, Al E., Tuttle, Jamison B., Updyke, Lawrence, Verhoest, Patrick R., Wei, Liuqing, Yang, Qingyi, Zhu, Yuao

Volltext

Acoustic Ejection Mass Spectrometry for High-Throughput Analysis von Zhang, Hui, Liu, Chang, Hua, Wenyi, Ghislain, Lucien P, Liu, Jianhua, Aschenbrenner, Lisa, Noell, Stephen, Dirico, Kenneth J, Lanyon, Lorraine F, Steppan, Claire M, West, Mike, Arnold, Don W, Covey, Thomas R, Datwani, Sammy S, Troutman, Matthew D

Volltext

Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies von Vincent, Fabien, Loria, Paula M., Weston, Andrea D., Steppan, Claire M., Doyonnas, Regis, Wang, Yue-Ming, Rockwell, Kristin L., Peakman, Marie-Claire

Volltext

The current biology of resistin von Steppan, Claire M., Lazar, Mitchell A.

Volltext

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters von Dvorak, Vojtech, Wiedmer, Tabea, Ingles-Prieto, Alvaro, Altermatt, Patrick, Batoulis, Helena, Baerenz, Felix, Bender, Eckhard, Digles, Daniela, Durrenberger, Franz, Heitman, Laura H., IJzerman, Adriaan P., Kell, Douglas B., Kickinger, Stefanie, Koerzoe, Daniel, Leippe, Philipp, Licher, Thomas, Manolova, Vania, Rizzetto, Riccardo, Sassone, Francesca, Scarabottolo, Lia, Schlessinger, Avner, Schneider, Vanessa, Sijben, Hubert J., Steck, Anna-Lena, Sundstrom, Hanna, Tremolada, Sara, Wilhelm, Maria, Wright Muelas, Marina, Zindel, Diana, Steppan, Claire M., Superti-Furga, Giulio

Volltext

Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study von Zhu, Yuao, Binder, Joe, Yurgelonis, Irina, Rai, Devendra K., Lazarro, Sarah, Costales, Chester, Kobylarz, Keith, McMonagle, Patricia, Steppan, Claire M., Aschenbrenner, Lisa, Anderson, Annaliesa S., Cardin, Rhonda D.

Volltext

Regulation of Fasted Blood Glucose by Resistin von Banerjee, Ronadip R., Rangwala, Shamina M., Shapiro, Jennifer S., Rich, A. Sophie, Rhoades, Ben, Qi, Yong, Wang, Juan, Rajala, Michael W., Pocai, Alessandro, Scherer, Phillipp E., Steppan, Claire M., Ahima, Rexford S., Obici, Silvana, Rossetti, Luciano, Lazar, Mitchell A.

Volltext

Resistin and obesity-associated insulin resistance von Steppan, Claire M, Lazar, Mitchell A

Volltext

Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies von Bajaj, Piyush, Rodrigues, A David, Steppan, Claire M, Engle, Sandra J, Mathialagan, Sumathy, Schroeter, Thomas

Volltext

Activation of SOCS-3 by Resistin von Steppan, Claire M., Wang, Juan, Whiteman, Eileen L., Birnbaum, Morris J., Lazar, Mitchell A.

Volltext

The hormone resistin links obesity to diabetes von Lazar, Mitchell A, Steppan, Claire M, Bailey, Shannon T, Bhat, Savitha, Brown, Elizabeth J, Banerjee, Ronadip R, Wright, Christopher M, Patel, Hiralben R, Ahima, Rexford S

Volltext

Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators von Chappie, Thomas A, Abdelmessih, Mario, Ambroise, Claude W, Boehm, Markus, Cai, Mi, Green, Michael, Guilmette, Edward, Steppan, Claire M, Stevens, Lucy M, Wei, Liuqing, Xi, Simon, Hasson, Samuel A

Volltext

Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE von Seneviratne, Uthpala, Huang, Zhen, am Ende, Christopher W., Butler, Todd W., Cleary, Leah, Dresselhaus, Erica, Evrard, Edelweiss, Fisher, Ethan L., Green, Michael E., Helal, Christopher J., Humphrey, John M., Lanyon, Lorraine F., Marconi, Michael, Mukherjee, Paramita, Sciabola, Simone, Steppan, Claire M., Sylvain, Emily K., Tuttle, Jamison B., Verhoest, Patrick R., Wager, Travis T., Xie, Longfei, Ramaswamy, Gayathri, Johnson, Douglas S., Pettersson, Martin

Volltext

A futile metabolic cycle activated in adipocytes by antidiabetic agents von Lazar, Mitchell A, Guan, Hong-Ping, Li, Yong, Jensen, Mette Valentin, Newgard, Christopher B, Steppan, Claire M

Volltext

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation von O’Neill, Brian T, Beck, Elizabeth M, Butler, Christopher R, Nolan, Charles E, Gonzales, Cathleen, Zhang, Lei, Doran, Shawn D, Lapham, Kimberly, Buzon, Leanne M, Dutra, Jason K, Barreiro, Gabriela, Hou, Xinjun, Martinez-Alsina, Luis A, Rogers, Bruce N, Villalobos, Anabella, Murray, John C, Ogilvie, Kevin, LaChapelle, Erik A, Chang, Cheng, Lanyon, Lorraine F, Steppan, Claire M, Robshaw, Ashley, Hales, Katherine, Boucher, Germaine G, Pandher, Karamjeet, Houle, Christopher, Ambroise, Claude W, Karanian, David, Riddell, David, Bales, Kelly R, Brodney, Michael A

Volltext

A Family of Tissue-Specific Resistin-like Molecules von Steppan, Claire M., Brown, Elizabeth J., Wright, Christopher M., Bhat, Savitha, Banerjee, Ronadip R., Dai, Charlotte Y., Enders, Gregory H., Silberg, Debra G., Wen, Xiaoming, Wu, Gary D., Lazar, Mitchell A.

Volltext

Structural basis of the acyl-transfer mechanism of human GPAT1 von Johnson, Zachary Lee, Ammirati, Mark, Wasilko, David Jonathan, Chang, Jeanne S., Noell, Stephen, Foley, Timothy L., Yoon, Hyejin, Smith, Kathleen, Asano, Shoh, Hales, Katherine, Wan, Min, Yang, Qingyi, Piotrowski, Mary A., Farley, Kathleen A., Gilbert, Tamara, Aschenbrenner, Lisa M., Fennell, Kimberly F., Dutra, Jason K., Xu, Mary, Guo, Chunyang, Varghese, Alison E., Bellenger, Justin, Quinn, Alandra, am Ende, Christopher W., West, Graham M., Griffor, Matthew C., Bennett, Donald, Calabrese, Matthew, Steppan, Claire M., Han, Seungil, Wu, Huixian

Volltext