Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense von Gleason, Julie E., Galaleldeen, Ahmad, Peterson, Ryan L., Taylor, Alexander B., Holloway, Stephen P., Waninger-Saroni, Jessica, Cormack, Brendan P., Cabelli, Diane E., Hart, P. John, Culotta, Valeria Cizewski

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DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation von Kwon, Youngho, Rösner, Heike, Zhao, Weixing, Selemenakis, Platon, He, Zhuoling, Kawale, Ajinkya S., Katz, Jeffrey N., Rogers, Cody M., Neal, Francisco E., Badamchi Shabestari, Aida, Petrosius, Valdemaras, Singh, Akhilesh K., Joel, Marina Z., Lu, Lucy, Holloway, Stephen P., Burma, Sandeep, Mukherjee, Bipasha, Hromas, Robert, Mazin, Alexander, Wiese, Claudia, Sørensen, Claus S., Sung, Patrick

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Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites von Valentim, Claudia L. L., Cioli, Donato, Chevalier, Frédéric D., Cao, Xiaohang, Taylor, Alexander B., Holloway, Stephen P., Pica-Mattoccia, Livia, Guidi, Alessandra, Basso, Annalisa, Tsai, Isheng J., Berriman, Matthew, Carvalho-Queiroz, Claudia, Almeida, Marcio, Aguilar, Hector, Frantz, Doug E., Hart, P. John, LoVerde, Philip T., Anderson, Timothy J. C.

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Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae von Becker, Argentina, Kannan, T R, Taylor, Alexander B, Pakhomova, Olga N, Zhang, Yanfeng, Somarajan, Sudha R, Galaleldeen, Ahmad, Holloway, Stephen P, Baseman, Joel B, Hart, P John

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An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans von Guzman, Meghan A, Rugel, Anastasia R, Tarpley, Reid S, Alwan, Sevan N, Chevalier, Frédéric D, Kovalskyy, Dmytro P, Cao, Xiaohang, Holloway, Stephen P, Anderson, Timothy J C, Taylor, Alexander B, McHardy, Stanton F, LoVerde, Philip T

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Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1 von Clark, Nathaniel E., Katolik, Adam, Roberts, Kenneth M., Taylor, Alexander B., Holloway, Stephen P., Schuermann, Jonathan P., Montemayor, Eric J., Stevens, Scott W., Fitzpatrick, Paul F., Damha, Masad J., Hart, P. John

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Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine von Taylor, Alexander B, Pica-Mattoccia, Livia, Polcaro, Chiara M, Donati, Enrica, Cao, Xiaohang, Basso, Annalisa, Guidi, Alessandra, Rugel, Anastasia R, Holloway, Stephen P, Anderson, Timothy J C, Hart, P John, Cioli, Donato, LoVerde, Philip T

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Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1 von Montemayor, Eric J, Katolik, Adam, Clark, Nathaniel E, Taylor, Alexander B, Schuermann, Jonathan P, Combs, D Joshua, Johnsson, Richard, Holloway, Stephen P, Stevens, Scott W, Damha, Masad J, Hart, P John

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Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis von Seetharaman, Sai V., Prudencio, Mercedes, Karch, Celeste, Holloway, Stephen P., Borchelt, David R., Hart, P. John

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Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? von Rugel, Anastasia R., Guzman, Meghan A., Taylor, Alexander B., Chevalier, Frédéric D., Tarpley, Reid S., McHardy, Stanton F., Cao, Xiaohang, Holloway, Stephen P., Anderson, Timothy J.C., Hart, P. John, LoVerde, Philip T.

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Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A von Galaleldeen, Ahmad, Strange, Richard W., Whitson, Lisa J., Antonyuk, Svetlana V., Narayana, Narendra, Taylor, Alexander B., Schuermann, Jonathan P., Holloway, Stephen P., Hasnain, S. Samar, Hart, P. John

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Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis von Cao, Xiaohang, Antonyuk, Svetlana V., Seetharaman, Sai V., Whitson, Lisa J., Taylor, Alexander B., Holloway, Stephen P., Strange, Richard W., Doucette, Peter A., Valentine, Joan Selverstone, Tiwari, Ashutosh, Hayward, Lawrence J., Padua, Shelby, Cohlberg, Jeffrey A., Hasnain, S. Samar, Hart, P. John

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Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection von Zhang, Shen-Ying, Clark, Nathaniel E., Freije, Catherine A., Pauwels, Elodie, Taggart, Allison J., Okada, Satoshi, Mandel, Hanna, Garcia, Paula, Ciancanelli, Michael J., Biran, Anat, Lafaille, Fabien G., Tsumura, Miyuki, Cobat, Aurélie, Luo, Jingchuan, Volpi, Stefano, Zimmer, Bastian, Sakata, Sonoko, Dinis, Alexandra, Ohara, Osamu, Garcia Reino, Eduardo J., Dobbs, Kerry, Hasek, Mary, Holloway, Stephen P., McCammon, Karen, Hussong, Stacy A., DeRosa, Nicholas, Van Skike, Candice E., Katolik, Adam, Lorenzo, Lazaro, Hyodo, Maki, Faria, Emilia, Halwani, Rabih, Fukuhara, Rie, Smith, Gregory A., Galvan, Veronica, Damha, Masad J., Al-Muhsen, Saleh, Itan, Yuval, Boeke, Jef D., Notarangelo, Luigi D., Studer, Lorenz, Kobayashi, Masao, Diogo, Luisa, Fairbrother, William G., Abel, Laurent, Rosenberg, Brad R., Hart, P. John, Etzioni, Amos, Casanova, Jean-Laurent

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Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain von Clark, Nathaniel E., Katolik, Adam, Gallant, Pascal, Welch, Anastasia, Murphy, Eileen, Buerer, Luke, Schorl, Christoph, Naik, Nandita, Naik, Mandar T., Holloway, Stephen P., Cano, Kristin, Weintraub, Susan T., Howard, Katherine M., Hart, P. John, Jogl, Gerwald, Damha, Masad J., Fairbrother, William G.

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Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product von Clark, Nathaniel E., Katolik, Adam, Welch, Anastasia, Schorl, Christoph, Holloway, Stephen P., Schuermann, Jonathan P., Hart, P. John, Taylor, Alexander B., Damha, Masad J., Fairbrother, William G.

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Insights into the Role of the Unusual Disulfide Bond in Copper-Zinc Superoxide Dismutase von Sea, Kevin, Sohn, Se Hui, Durazo, Armando, Sheng, Yuewei, Shaw, Bryan F., Cao, Xiaohang, Taylor, Alexander B., Whitson, Lisa J., Holloway, Stephen P., Hart, P. John, Cabelli, Diane E., Gralla, Edith Butler, Valentine, Joan Selverstone

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Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment von Chevalier, Frédéric D, Le Clec'h, Winka, McDew-White, Marina, Menon, Vinay, Guzman, Meghan A, Holloway, Stephen P, Cao, Xiaohang, Taylor, Alexander B, Kinung'hi, Safari, Gouvras, Anouk N, Webster, Bonnie L, Webster, Joanne P, Emery, Aidan M, Rollinson, David, Garba Djirmay, Amadou, Al Mashikhi, Khalid M, Al Yafae, Salem, Idris, Mohamed A, Moné, Hélène, Mouahid, Gabriel, Hart, P John, LoVerde, Philip T, Anderson, Timothy J C

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Metal content and kinetic properties of yeast RNA lariat debranching enzyme Dbr1 von Clark, Nathaniel E, Katolik, Adam, Taggart, Allison J, Buerer, Luke, Holloway, Stephen P, Miller, Nathaniel, Phillips, John D, Farrell, Colin P, Damha, Masad J, Fairbrother, William G

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A pH Switch Controls Zinc Binding in Tomato Copper–Zinc Superoxide Dismutase von Sea, Kevin W, Taylor, Alexander B, Thomas, Susan T, Liba, Amir, Bergman, Isabelle B, Holloway, Stephen P, Cao, Xiaohang, Gralla, Edith B, Valentine, Joan S, Hart, P. John, Galaleldeen, Ahmad

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Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy von Taylor, Alexander B., Roberts, Kenneth M., Cao, Xiaohang, Clark, Nathaniel E., Holloway, Stephen P., Donati, Enrica, Polcaro, Chiara M., Pica-Mattoccia, Livia, Tarpley, Reid S., McHardy, Stanton F., Cioli, Donato, LoVerde, Philip T., Fitzpatrick, Paul F., Hart, P. John

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