Humanized mice as preclinical models for myeloid malignancies von Gbyli, Rana, Song, Yuanbin, Halene, Stephanie

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High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue von Liu, Yang, Yang, Mingyu, Deng, Yanxiang, Su, Graham, Enninful, Archibald, Guo, Cindy C., Tebaldi, Toma, Zhang, Di, Kim, Dongjoo, Bai, Zhiliang, Norris, Eileen, Pan, Alisia, Li, Jiatong, Xiao, Yang, Halene, Stephanie, Fan, Rong

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Inflammasome activation in infected macrophages drives COVID-19 pathology von Sefik, Esen, Qu, Rihao, Junqueira, Caroline, Kaffe, Eleanna, Mirza, Haris, Zhao, Jun, Brewer, J. Richard, Han, Ailin, Steach, Holly R., Israelow, Benjamin, Blackburn, Holly N., Velazquez, Sofia E., Chen, Y. Grace, Halene, Stephanie, Iwasaki, Akiko, Meffre, Eric, Nussenzweig, Michel, Lieberman, Judy, Wilen, Craig B., Kluger, Yuval, Flavell, Richard A.

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Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation von Gu, Sean X., Tyagi, Tarun, Jain, Kanika, Gu, Vivian W., Lee, Seung Hee, Hwa, Jonathan M., Kwan, Jennifer M., Krause, Diane S., Lee, Alfred I., Halene, Stephanie, Martin, Kathleen A., Chun, Hyung J., Hwa, John

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Development and function of human innate immune cells in a humanized mouse model von Rongvaux, Anthony, Willinger, Tim, Martinek, Jan, Strowig, Till, Gearty, Sofia V, Teichmann, Lino L, Saito, Yasuyuki, Marches, Florentina, Halene, Stephanie, Palucka, A Karolina, Manz, Markus G, Flavell, Richard A

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How do messenger RNA splicing alterations drive myelodysplasia? von Joshi, Poorval, Halene, Stephanie, Abdel-Wahab, Omar

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The Coming of Age of Preclinical Models of MDS von Liu, Wei, Teodorescu, Patric, Halene, Stephanie, Ghiaur, Gabriel

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SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells von Liang, Yang, Tebaldi, Toma, Rejeski, Kai, Joshi, Poorval, Stefani, Giovanni, Taylor, Ashley, Song, Yuanbin, Vasic, Radovan, Maziarz, Jamie, Balasubramanian, Kunthavai, Ardasheva, Anastasia, Ding, Alicia, Quattrone, Alessandro, Halene, Stephanie

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Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice von Xavier-Ferrucio, Juliana, Scanlon, Vanessa, Li, Xiuqi, Zhang, Ping-Xia, Lozovatsky, Larisa, Ayala-Lopez, Nadia, Tebaldi, Toma, Halene, Stephanie, Cao, Chang, Fleming, Mark D., Finberg, Karin E., Krause, Diane S.

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Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms von Taylor, Justin, Mi, Xiaoli, North, Khrystyna, Binder, Moritz, Penson, Alexander, Lasho, Terra, Knorr, Katherine, Haddadin, Michael, Liu, Bo, Pangallo, Joseph, Benbarche, Salima, Wiseman, Daniel, Tefferi, Ayalew, Halene, Stephanie, Liang, Yang, Patnaik, Mrinal M., Bradley, Robert K., Abdel-Wahab, Omar

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A neutrophil activation signature predicts critical illness and mortality in COVID-19 von Meizlish, Matthew L., Pine, Alexander B., Bishai, Jason D., Goshua, George, Nadelmann, Emily R., Simonov, Michael, Chang, C-Hong, Zhang, Hanming, Shallow, Marcus, Bahel, Parveen, Owusu, Kent, Yamamoto, Yu, Arora, Tanima, Atri, Deepak S., Patel, Amisha, Gbyli, Rana, Kwan, Jennifer, Won, Christine H., Dela Cruz, Charles, Price, Christina, Koff, Jonathan, King, Brett A., Rinder, Henry M., Wilson, F. Perry, Hwa, John, Halene, Stephanie, Damsky, William, van Dijk, David, Lee, Alfred I., Chun, Hyung J.

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Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice von Saito, Yasuyuki, Ellegast, Jana M., Rafiei, Anahita, Song, Yuanbin, Kull, Daniel, Heikenwalder, Mathias, Rongvaux, Anthony, Halene, Stephanie, Flavell, Richard A., Manz, Markus G.

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A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies von Song, Yuanbin, Rongvaux, Anthony, Taylor, Ashley, Jiang, Tingting, Tebaldi, Toma, Balasubramanian, Kunthavai, Bagale, Arun, Terzi, Yunus Kasim, Gbyli, Rana, Wang, Xiaman, Fu, Xiaoying, Gao, Yimeng, Zhao, Jun, Podoltsev, Nikolai, Xu, Mina, Neparidze, Natalia, Wong, Ellice, Torres, Richard, Bruscia, Emanuela M., Kluger, Yuval, Manz, Markus G., Flavell, Richard A., Halene, Stephanie

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ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control von Gao, Yimeng, Zimmer, Joshua T., Vasic, Radovan, Liu, Chengyang, Gbyli, Rana, Zheng, Shu-Jian, Patel, Amisha, Liu, Wei, Qi, Zhihong, Li, Yaping, Nelakanti, Raman, Song, Yuanbin, Biancon, Giulia, Xiao, Andrew Z., Slavoff, Sarah, Kibbey, Richard G., Flavell, Richard A., Simon, Matthew D., Tebaldi, Toma, Li, Hua-Bing, Halene, Stephanie

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Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells von Song, Yuanbin, Shan, Liang, Gbyli, Rana, Liu, Wei, Strowig, Till, Patel, Amisha, Fu, Xiaoying, Wang, Xiaman, Xu, Mina L, Gao, Yimeng, Qin, Ashley, Bruscia, Emanuela M, Tebaldi, Toma, Biancon, Giulia, Mamillapalli, Padmavathi, Urbonas, David, Eynon, Elizabeth, Gonzalez, David G, Chen, Jie, Krause, Diane S, Alderman, Jonathan, Halene, Stephanie, Flavell, Richard A

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Circulating markers of angiogenesis and endotheliopathy in COVID-19 von Pine, Alexander B., Meizlish, Matthew L., Goshua, George, Chang, C-Hong, Zhang, Hanming, Bishai, Jason, Bahel, Parveen, Patel, Amisha, Gbyli, Rana, Kwan, Jennifer M., Won, Christine H., Price, Christina, Dela Cruz, Charles S., Halene, Stephanie, van Dijk, David, Hwa, John, Lee, Alfred I., Chun, Hyung J.

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Selective inhibition of MCL1 overcomes venetoclax resistance in a murine model of myelodysplastic syndromes von Fischer, Melissa A, Song, Yuanbin, Arrate, Maria P, Gbyli, Rana, Villaume, Matthew T, Smith, Brianna N, Childress, Merrida A, Stricker, Thomas P, Halene, Stephanie, Savona, Michael R

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DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation von Jawad, Majd, Afkhami, Michelle, Ding, Yi, Zhang, Xiaohui, Li, Peng, Young, Kim, Xu, Mina Luqing, Cui, Wei, Zhao, Yiqing, Halene, Stephanie, Al-Kali, Aref, Viswanatha, David, Chen, Dong, He, Rong, Zheng, Gang

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Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq von Gao, Yimeng, Chen, Shirui, Halene, Stephanie, Tebaldi, Toma

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Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes von Gao, Yuan, Smith, Elenoe, Ker, Elmer, Campbell, Phil, Cheng, Ee-chun, Zou, Siying, Lin, Sharon, Wang, Lin, Halene, Stephanie, Krause, Diane S.

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