Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers von Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Zhang, Bailin, He, Timothy, Gao, Qiang, Gee, Patricia, Simard, Daniel, Castaldi, M. Paola, Tomlinson, Ronald, Reiling, Stephan, Barrague, Matthieu, Newcombe, Richard, Cao, Hui, Wang, Yanjun, Sun, Fangxian, Murtie, Joshua, Munson, Mark, Yang, Eric, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Cheng, Hong, Adrian, Francisco, Winter, Christopher, Licht, Stuart, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron

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Similarity Searching of Chemical Databases Using Atom Environment Descriptors (MOLPRINT 2D):  Evaluation of Performance von Bender, Andreas, Mussa, Hamse Y, Glen, Robert C, Reiling, Stephan

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Molecular Similarity Searching Using Atom Environments, Information-Based Feature Selection, and a Naïve Bayesian Classifier von Bender, Andreas, Mussa, Hamse Y, Glen, Robert C, Reiling, Stephan

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A novel computational method for comparing vibrational circular dichroism spectra von Shen, Jian, Zhu, Chengyue, Reiling, Stephan, Vaz, Roy

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A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine von Guo, Hongqiu, Camargo, L. Miguel, Yeboah, Fred, Digan, Mary Ellen, Niu, Honglin, Pan, Yue, Reiling, Stephan, Soler-Llavina, Gilberto, Weihofen, Wilhelm A., Wang, Hao-Ran, Shanker, Y. Gopi, Stams, Travis, Bill, Anke

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Screenit: Visual Analysis of Cellular Screens von Dinkla, Kasper, Strobelt, Hendrik, Genest, Bryan, Reiling, Stephan, Borowsky, Mark, Pfister, Hanspeter

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Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators von Vaz, Roy J., Li, Yi, Chellaraj, Vinolia, Reiling, Stephan, Kuntzweiler, Theresa, Yang, Donglai, Shen, Hong, Batchelor, Joseph D., Zhang, Ying, Chen, Xin, McLean, Larry R., Kosley, Raymond

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Identification of optimum computational protocols for modeling the aryl hydrocarbon receptor (AHR) and its interaction with ligands von Jogalekar, Ashutosh S., Reiling, Stephan, Vaz, Roy J.

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Prediction of the 3D Structure and Dynamics of Human DP G-Protein Coupled Receptor Bound to an Agonist and an Antagonist von Li, Youyong, Zhu, Fangqiang, Vaidehi, Nagarajan, Goddard, William A, Sheinerman, Felix, Reiling, Stephan, Morize, Isabelle, Mu, Lan, Harris, Keith, Ardati, Ali, Laoui, Abdelazize

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Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening von McLean, Larry R., Zhang, Ying, Li, Hua, Li, Ziyu, Lukasczyk, Ulrike, Choi, Yong-Mi, Han, Zuoning, Prisco, Joy, Fordham, Jeremy, Tsay, Joseph T., Reiling, Stephan, Vaz, Roy J., Li, Yi

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Abstract 2201: The molecular signature of tumor cells that are sensitives to a new tight binder NAMPT inhibitor von Hilairet, Sandrine, Arigon, Jerome, Nardi, Frederico, Jegham, Samir, Peleraux, Annick, Cosnier, Sylvie, Floutard, Regine, Jbilo, Omar, August, Paul, Shomali, Maysoun, Autelitano, Francois, Arrebola, Rosalia, Reiling, Stephan, Pollard, Jack, Adrian, Francisco, Sager, Jason, Lengauer, Christoph, Dorsh, Marion, Garcia-Echeverria, Carlos, Bouaboula, Monsif

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Abstract 3135: In vitro and in vivo synthetic lethal screens to identify novel targets in the context of PTEN deficiency von Zhang, Jing-xin, Murtie, Joshua, Iartchouk, Oleg, Cao, Hui, Shapiro, Gary, Li, Zhifang, Wang, Hongyun, Ding, Zhihu, Zhang, Yu-an, Light, Madelyn, Hoffman, Dietmar, Cindhuchao, May, Jani, Saurin, Newcombe, Richard, Bric-Furlong, Eva, Wu, Bin, Virone-Oddos, Angela, Reiling, Stephan, Theihaber, Joachim, Lengauer, Christoph, Pollard, Jack, Watters, James, Silver, Serena, Reddy, Venkat

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Abstract 2243: Clonogenic 3D high throughput screening in mutant KRAS dependent cancer cells - a chemogenomic approach von Koundinya, Malvika, Sudhalter, Judith, Courjaud, Albane, Lionne, Bruno, Touyer, Gaetan, Bonnet, Luc, Menguy, Isabelle, Schreiber, Isabelle, Perrault, Christelle, Vougier, Stephanie, Benhamou, Brigitte, Simard, Daniel, Castaldi, Maria Paola, Tomlinson, Ronald, Reiling, Stephan, Cao, Hui, Harper, David, Bouaboula, Monsif, Pollard, Jack, Grepin, Claudine, Garcia-Echeverria, Carlos, Adrian, Francisco, Cornella-Taracido, Ivan, Arrebola, Rosalia, Morris, Aaron J.

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On the mechanism of microsomal prostaglandin E synthase type-2 - A theoretical study of endoperoxide reaction with MeS super(-) von Li, Yi, Angelastro, Michael, Shimshock, Stephen, Reiling, Stephan, Vaz, Roy J

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On the mechanism of microsomal prostaglandin E synthase type-2—A theoretical study of endoperoxide reaction with MeS von Li, Yi, Angelastro, Michael, Shimshock, Stephen, Reiling, Stephan, Vaz, Roy J.

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Abstract A226: Mechanism of action of iniparib: Stimulation of reactive oxygen species (ROS) production in an iniparib-sensitive breast cancer cell line von Licht, Stuart, Cao, Hui, Li, Zhifang, Zhang, Jingxin, Liu, Feng, Brittain, Scott, Shen, Junqing, Zhang, Bailin, Hopke, Joern, Newcombe, Rick, Reiling, Stephan, Pollard, Jack, Watters, James, Cheng, Hong, Reddy, Venkateshwar, Bergstrom, Donald A.

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Force field parameters for carbohydrates von Reiling, Stephan, Schlenkrich, Michael, Brickmann, Jürgen

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Theoretical Studies on the Pyridine−I2 Charge-Transfer Complex. 1. Ab-Initio Calculations on I2 and Pyridine−I2 von Reiling, Stephan, Besnard, Marcel, Bopp, Philippe A

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Theoretical Studies on the Pyridine−I 2 Charge-Transfer Complex. 1. Ab-Initio Calculations on I 2 and Pyridine−I 2 von Reiling, Stephan, Besnard, Marcel, Bopp, Philippe A.

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Theoretical investigations on 1,2-ethanediol: The problem of intramolecular hydrogen bonds von Reiling, Stephan, Brickmann, Jürgen, Schlenkrich, Michael, Bopp, Philippe A.

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