Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies von Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.

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Proteomic analysis of mantle-cell lymphoma by protein microarray von Ghobrial, Irene M., McCormick, Daniel J., Kaufmann, Scott H., Leontovich, Alexey A., Loegering, David A., Dai, Nga T., Krajnik, Kelly L., Stenson, Mary J., Melhem, Mona F., Novak, Anne J., Ansell, Stephen M., Witzig, Thomas E.

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Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma von Yang, Zhi-Zhang, Novak, Anne J., Stenson, Mary J., Witzig, Thomas E., Ansell, Stephen M.

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Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair von Abeykoon, Jithma P., Wu, Xiaosheng, Nowakowski, Kevin E., Dasari, Surendra, Paludo, Jonas, Weroha, S. John, Hu, Chunling, Hou, Xiaonan, Sarkaria, Jann N., Mladek, Ann C., Phillips, Jessica L., Feldman, Andrew L., Ravindran, Aishwarya, King, Rebecca L., Boysen, Justin, Stenson, Mary J., Carr, Ryan M., Manske, Michelle K., Molina, Julian R., Kapoor, Prashant, Parikh, Sameer A., Kumar, Shaji, Robinson, Steven I., Yu, Jia, Boughey, Judy C., Wang, Liewei, Goetz, Matthew P., Couch, Fergus J., Patnaik, Mrinal M., Witzig, Thomas E.

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MCIR1: A patient‐derived mantle cell lymphoma line for discovering new treatments for ibrutinib resistance von Wu, Xiaosheng, Nowakowski, Kevin E., Abeykoon, Jithma P., Manske, Michelle, Stenson, Mary J., Timm, Michael M., Hanson, Curtis A., Van Dyke, Daniel L., Dasari, Surendra, Witzig, Thomas E.

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Prognostic and therapeutic significance of phosphorylated STAT3 and protein tyrosine phosphatase-6 in peripheral-T cell lymphoma von Han, Jing Jing, O’byrne, Megan, Stenson, Mary J., Maurer, Matthew J., Wellik, Linda E., Feldman, Andrew L., McPhail, Ellen D., Witzig, Thomas E., Gupta, Mamta

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Translation initiation complex eIF4F is a therapeutic target for dual mTOR kinase inhibitors in non-Hodgkin lymphoma von Demosthenous, Christos, Han, Jing Jing, Stenson, Mary J, Maurer, Matthew J, Wellik, Linda E, Link, Brian, Hege, Kristen, Dogan, Ahmet, Sotomayor, Eduardo, Witzig, Thomas, Gupta, Mamta

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Elevated soluble IL‐2Rα, IL‐8, and MIP‐1β levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma von Sonbol, Mohamad B., Maurer, Matthew J., Stenson, Mary J., Allmer, Cristine, LaPlant, Betsy R., Weiner, George J., Macon, William R., Cerhan, James R., Witzig, Thomas E., Gupta, Mamta

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Elevated serum monoclonal and polyclonal free light chains and interferon inducible protein‐10 predicts inferior prognosis in untreated diffuse large B‐cell lymphoma von Witzig, Thomas E., Maurer, Matthew J., Stenson, Mary J., Allmer, Cristine, Macon, William, Link, Brian, Katzmann, Jerry A., Gupta, Mamta

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The effect of CRM1 inhibition on human non-Hodgkin lymphoma cells von Abeykoon, Jithma P., Paludo, Jonas, Nowakowski, Kevin E., Stenson, Mary J., King, Rebecca L., Wellik, Linda E., Wu, Xiaosheng, Witzig, Thomas E.

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Analysis of clonal B‐cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B‐chronic lymphocytic leukaemia von Jelinek, Diane F., Tschumper, Renee C., Geyer, Susan M., Bone, Nancy D., Dewald, Gordon W., Hanson, Curtis A., Stenson, Mary J., Witzig, Thomas E., Tefferi, Ayalew, Kay, Neil E.

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Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma von Ghobrial, Irene M., Bone, Nancy D., Stenson, Mary J., Novak, Anne, Hedin, Karen E., Kay, Neil E., Ansell, Stephen M.

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Oncogenic Role of Chromatin Modifier Polycomb Repressive Complex-2 in Mantle Cell Lymphoma von Gupta, Mamta, Demosthenous, Christos, Stenson, Mary J, Price-Troska, Tammy

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Abstract 650: MCIR1: A patient-derived ibrutinib-resistant mantle cell lymphoma line for the study of ibrutinib resistance and drug discovery von Nowakowski, Kevin E., Abeykoon, Jithma P., Stenson, Mary J., Timm, Michael M., Hanson, Curtis A., Van Dyke, Daniel L., Novak, Anne J., Wu, Xiaosheng, Witzig, Thomas E.

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Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy von Witzig, T E, Hu, G, Offer, S M, Wellik, L E, Han, J J, Stenson, M J, Dogan, A, Diasio, R B, Gupta, M

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Salicylates Potentiate and Broaden CRM1 Inhibitor Anti-Tumor Activity Via S-Phase Arrest and Impaired DNA-Damage Repair von Abeykoon, Jithma P., Wu, Xiaosheng, Nowakowski, Kevin E., Dasari, Surendra, Paludo, Jonas, Weroha, S. John, Hu, Chunling, Sarkaria, Jann, Mladek, Ann, Phillips, Jessica, Feldman, Andrew L., Ravindran, Aishwarya, King, Rebecca L., Stenson, Mary J., Manske, Michelle, Couch, Fergus, Patnaik, Mrinal M., Witzig, Thomas E.

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Elevated soluble IL-2R[alpha], IL-8, and MIP-1[beta] levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma von Sonbol, Mohamad B, Maurer, Matthew J, Stenson, Mary J, Allmer, Cristine, LaPlant, Betsy R, Weiner, George J, Macon, William R, Cerhan, James R, Witzig, Thomas E, Gupta, Mamta

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Elevated soluble IL ‐2 R α, IL ‐8, and MIP ‐1β levels are associated with inferior outcome and are independent of MIPI score in patients with mantle cell lymphoma von Sonbol, Mohamad B., Maurer, Matthew J., Stenson, Mary J., Allmer, Cristine, LaPlant, Betsy R., Weiner, George J., Macon, William R., Cerhan, James R., Witzig, Thomas E., Gupta, Mamta

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Intratumoral CD4+CD25+ Regulatory T-Cell-Mediated Suppression of Infiltrating CD4+ T-Cells in B-Cell Non-Hodgkin Lymphoma von Yang, Zhi-Zhang, Novak, Anne J., Stenson, Mary J., Witzig, Thomas E., Ansell, Stephen M.

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Intratumoral Treg Cells Completely Inhibit the Induction and Function of Tumor-Infiltrating CD8+ T-Cells in B-Cell NHL von Yang, Zhi-Zhang, Novak, Anne J., Stenson, Mary J., Witzig, Thomas E., Ansell, Stephen M.

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