Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors von Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment o... von Lewis, Richard T, Bode, Christiane M, Choquette, Deborah M, Potashman, Michele, Romero, Karina, Stellwagen, John C, Teffera, Yohannes, Moore, Earl, Whittington, Douglas A, Chen, Hao, Epstein, Linda F, Emkey, Renee, Andrews, Paul S, Yu, Violeta L, Saffran, Douglas C, Xu, Man, Drew, Allison, Merkel, Patricia, Szilvassy, Steven, Brake, Rachael L

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Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors von Peterson, Emily A., Boezio, Alessandro A., Andrews, Paul S., Boezio, Christiane M., Bush, Tammy L., Cheng, Alan C., Choquette, Deborah, Coats, James R., Colletti, Adria E., Copeland, Katrina W., DuPont, Michelle, Graceffa, Russell, Grubinska, Barbara, Kim, Joseph L., Lewis, Richard T., Liu, Jingzhou, Mullady, Erin L., Potashman, Michele H., Romero, Karina, Shaffer, Paul L., Stanton, Mary K., Stellwagen, John C., Teffera, Yohannes, Yi, Shuyan, Cai, Ti, La, Daniel S.

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Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup von STELLWAGEN, John C, ADJABENG, George M, ROMINGER, Cynthia M, ROSSANESE, Olivia W, SMITHEMAN, Kimberly N, WATERSON, Alex G, UEHLING, David E, ARNONE, Marc R, DICKERSON, Scott H, CHAO HAN, HORNBERGER, Keith R, KING, Alastair J, MOOK, Robert A, PETROV, Kimberly G, RHEAULT, Tara R

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Abstract B88: A selective Raf kinase inhibitor induces cell death and tumor regression of human cancer cell lines encoding B-RafV600E mutation von Laquerre, Sylvie, Arnone, Marc, Moss, Katherine, Yang, Jingsong, Fisher, Kelly, Kane-Carson, Laurie S., Smitheman, Kimberly, Ward, Jessica, Heidrich, Bradley, Rheault, Tara, Adjabeng, George, Hornberger, Keith, Stellwagen, John, Waterson, Alex, Han, Chao, Mook, Robert A., Uehling, David, King, Alastair J.

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Viv... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in V... von Graceffa, Russell F, Boezio, Alessandro A, Able, Jessica, Altmann, Steven, Berry, Loren M, Boezio, Christiane, Butler, John R, Chu-Moyer, Margaret, Cooke, Melanie, DiMauro, Erin F, Dineen, Thomas A, Feric Bojic, Elma, Foti, Robert S, Fremeau, Jr, Robert T, Guzman-Perez, Angel, Gao, Hua, Gunaydin, Hakan, Huang, Hongbing, Huang, Liyue, Ilch, Christopher, Jarosh, Michael, Kornecook, Thomas, Kreiman, Charles R, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Lin, Min-Hwa Jasmine, Marx, Isaac E, Nguyen, Hanh N, Peterson, Emily A, Rescourio, Gwen, Roberts, John, Schenkel, Laurie, Shimanovich, Roman, Sparling, Brian A, Stellwagen, John, Taborn, Kristin, Vaida, Karina R, Wang, Jean, Yeoman, John, Yu, Violeta, Zhu, Dawn, Moyer, Bryan D, Weiss, Matthew M

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Orientation of the agarose gel matrix in pulsed electric fields von STELLWAGEN, J, STELLWAGEN, N. C

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Abstract 1795: Characterization of a novel series of potent, selective inhibitors of wild type and mutant/fusion anaplastic lymphoma kinase von Wilcoxen, Keith M., Brake, Rachael L., Saffran, Doug, Teffera, Yohannes, Choquette, Deborah, Whittington, Doug, Yu, Violeta, Romero, Karina, Bode, Christiane, Stellwagen, John, Potashman, Michelle, Emkey, Renee, Andrews, Paul, Drew, Allison E., Xu, Man, Szilvassy, Stephen, Al-Assad, Samer, Lewis, Richard T.

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment o... von Lewis, Richard T., Bode, Christiane M., Choquette, Deborah M., Potashman, Michele, Romero, Karina, Stellwagen, John C., Teffera, Yohannes, Moore, Earl, Whittington, Douglas A., Chen, Hao, Epstein, Linda F., Emkey, Renee, Andrews, Paul S., Yu, Violeta L., Saffran, Douglas C., Xu, Man, Drew, Allison, Merkel, Patricia, Szilvassy, Steven, Brake, Rachael L.

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Development of potent B-Raf super(V600E inhibitors containing an arylsulfonamide headgroup) von Stellwagen, John C, Adjabeng, George M, Arnone, Marc R, Dickerson, Scott H, Han, Chao, Hornberger, Keith R, King, Alastair J, Mook, Robert A, Petrov, Kimberly G, Rheault, Tara R, Rominger, Cynthia M, Rossanese, Olivia W, Smitheman, Kimberly N, Waterson, Alex G, Uehling, David E

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Development of potent B-Raf V600E inhibitors containing an arylsulfonamide headgroup von Stellwagen, John C., Adjabeng, George M., Arnone, Marc R., Dickerson, Scott H., Han, Chao, Hornberger, Keith R., King, Alastair J., Mook, Robert A., Petrov, Kimberly G., Rheault, Tara R., Rominger, Cynthia M., Rossanese, Olivia W., Smitheman, Kimberly N., Waterson, Alex G., Uehling, David E.

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Transient electric birefringence of agarose gels. I. Unidirectional electric fields von Stellwagen, John, Stellwagen, Nancy C.

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Cyclopropyl dihydroquinoline sulfonamide compounds von Marx, Isaac E, Milgram, Benjamin C, Zhao, Wei, Cherney, Alan H, Stellwagen, John

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METHODS OF TREATING NEUROLOGICAL DISORDERS von Hudson, Ryan, Fernando, Dilinie, Dransfield, Paul, Ma, Zhihua, Sparling, Brian, Harvey, James, Stellwagen, John, Beausoleil, Anne-Marie

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METHODS OF TREATING NEUROLOGICAL DISORDERS von Hudson, Ryan, Fernando, Dilinie, Dransfield, Paul, Ma, Zhihua, Sparling, Brian, Harvey, James, Stellwagen, John, Beausoleil, Anne-Marie

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CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS von MARX, ISSAC E, MILGRAM, BENJAMIN C, CHERNEY, ALAN H, ZHAO, WEI, STELLWAGEN, JOHN

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METHODS OF TREATING NEUROLOGICAL DISORDERS von BEAUSOLEIL, Anne-Marie, MA, Zhihua, HUDSON, Ryan, SPARLING, Brian, HARVEY, James, STELLWAGEN, John, FERNANDO, Dilinie, DRANSFIELD, Paul

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Methods of treating neurological disorders von Hudson, Ryan, Fernando, Dilinie, Dransfield, Paul, Ma, Zhihua, Sparling, Brian, Harvey, James, Stellwagen, John, Beausoleil, Anne-Marie

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CYCLOPROPYL DIHYDROQUINOLINE SULFONAMIDE COMPOUNDS von MARX, Isaac E, CHERNEY, Alan H, MILGRAM, Benjamin C, STELLWAGEN, John, ZHAO, Wei

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