Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies von Tran, John C, Tran, Daniel, Hilderbrand, Amy, Andersen, Nisana, Huang, Tao, Reif, Karin, Hotzel, Isidro, Stefanich, Eric G, Liu, Yichin, Wang, Jianyong

Volltext

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy von Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal

Volltext

Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent... von Yadav, Rajbharan, Sukumaran, Siddharth, Zabka, Tanja S, Li, Jinze, Oldendorp, Amy, Morrow, Gary, Reyes, Arthur, Cheu, Melissa, Li, Jessica, Wallin, Jeffrey J, Tsai, Siao, Sun, Laura, Wang, Peiyin, Ellerman, Diego, Spiess, Christoph, Polson, Andy, Stefanich, Eric G, Kamath, Amrita V, Ovacik, Meric A

Volltext

Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases von Stefanich, Eric G., Rae, Julie, Sukumaran, Siddharth, Lutman, Jeff, Lekkerkerker, Annemarie, Ouyang, Wenjun, Wang, Xiaoting, Lee, Donna, Danilenko, Dimitry M., Diehl, Lauri, Loyet, Kelly M., Herman, Ann

Volltext

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies von Mortensen, Deborah L., Prabhu, Saileta, Stefanich, Eric G., Kadkhodayan-Fischer, Saloumeh, Gelzleichter, Thomas R., Baker, Dana, Jiang, Jenny, Wallace, Kristin, Iyer, Suhasini, Fielder, Paul J., Putnam, Wendy S.

Volltext

Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Dise... von Yadav, Rajbharan, Sukumaran, Siddharth, Lutman, Jeff, Mitra, Mayur S., Halpern, Wendy, Sun, Tianhe, Setiadi, A. Francesca, Neighbors, Margaret, Sheng, X. Rebecca, Yip, Victor, Shen, Ben-Quan, Liu, Chang, Han, Lyrialle, Ovacik, Ayse Meric, Wu, Yan, Glickstein, Sara, Kunder, Rebecca, Arron, Joseph R., Pan, Lin, Kamath, Amrita V., Stefanich, Eric G.

Volltext

A Preclinical Population Pharmacokinetic Model for Anti‐CD20/CD3 T‐Cell‐Dependent Bispecific Antibodies von Ferl, Gregory Z., Reyes, Arthur, Sun, Liping L., Cheu, Melissa, Oldendorp, Amy, Ramanujan, Saroja, Stefanich, Eric G.

Volltext

Nonclinical safety assessment of a human interleukin‐22FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability von Lee, Donna W., Zhong, Shelly, Pai, Rama, Rae, Julie, Sukumaran, Siddharth, Stefanich, Eric G., Lutman, Jeff, Doudement, Estelle, Wang, Xiaoting, Harder, Brandon, Lekkerkerker, Annemarie, Herman, Ann, Ouyang, Wenjun, Danilenko, Dimitry M.

Volltext

Nonclinical safety assessment of a human interleukin‐22 FC IG  fusion protein demonstrates in vitro to in vivo and cross‐species translatability von Lee, Donna W., Zhong, Shelly, Pai, Rama, Rae, Julie, Sukumaran, Siddharth, Stefanich, Eric G., Lutman, Jeff, Doudement, Estelle, Wang, Xiaoting, Harder, Brandon, Lekkerkerker, Annemarie, Herman, Ann, Ouyang, Wenjun, Danilenko, Dimitry M.

Volltext

Dose schedule of recombinant murine thrombopoietin prior to myelosuppressive and myeloablative therapy in mice von STEFANICH, Eric G, CARLSON-ZERMENO, Catherine, MCEVOY, Karen, REICH, Mike, FIELDER, Paul J

Volltext

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele von Kauder, Steven E, Santell, Lydia, Mai, Elaine, Wright, Lilyan Y, Luis, Elizabeth, N'Diaye, Elsa N, Lutman, Jeff, Ratti, Navneet, Sa, Susan M, Maun, Henry R, Stefanich, Eric, Gonzalez, Lino C, Graham, Robert R, Diehl, Lauri, Faubion, Jr, William A, Keir, Mary E, Young, Judy, Chaudhuri, Amitabha, Lazarus, Robert A, Egen, Jackson G

Volltext

Pre-Clinical Characterization of T Cell-Dependent Bispecific Antibody Anti-CD79b/CD3 As a Potential Therapy for B Cell Malignancies von Sun, L. Laura, Chen, Xiaocheng, Chen, Yvonne, Dennis, Mark S., Ellerman, Diego, Johnson, Clarissa, Mathieu, Mary, Oldendorp, Amy, Polson, Andrew G., Reyes, Arthur, Stefanich, Eric, Wang, Hong, Wang, Peiyin, Zheng, Bing, Ebens, Allen J.

Volltext

Human platelets as a model for the binding and degradation of thrombopoietin von FIELDER, P. J, HASS, P, NAGEL, M, STEFANICH, E, WIDMER, R, BENNETT, G. L, KELLER, G.-A, DE SAUVAGE, F. J, EATON, D

Volltext

Role of the Distal Half of the c-Mpl Intracellular Domain in Control of Platelet Production by Thrombopoietin In Vivo von Luoh, Shiuh-Ming, Stefanich, Eric, Solar, Gregg, Steinmetz, Hope, Lipari, Terry, Pestina, Tamara I., Jackson, Carl W., de Sauvage, Frederic J.

Volltext

Metabolism of thrombopoietin (TPO) in vivo : Determination of the binding dynamics for TPO in mice von STEFANICH, E, SENN, T, WIDMER, R, FRATINO, C, KELLER, G.-K, FIELDER, P. J

Volltext