Roles of the Ras Raf MEK ERK pathway in leukemia therapy von Steelman, L S, Franklin, R A, Abrams, S L, Chappell, W, Kempf, C R, Bäsecke, J, Stivala, F, Donia, M, Fagone, P, Nicoletti, F, Libra, M, Ruvolo, P, Ruvolo, V, Evangelisti, C, Martelli, A M, McCubrey, J A

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Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K PTEN Akt mTOR pathway von Martelli, A M, Evangelisti, C, Chappell, W, Abrams, S L, Bäsecke, J, Stivala, F, Donia, M, Fagone, P, Nicoletti, F, Libra, M, Ruvolo, V, Ruvolo, P, Kempf, C R, Steelman, L S, McCubrey, J A

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Signal transduction mediated by the Ras Raf MEK ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention von CHANG, F, STEELMAN, L. S, LEE, J. T, SHELTON, J. G, NAVOLANIC, P. M, BLALOCK, W. L, FRANKLIN, R. A, MCCUBREY, J. A

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Targeting the leukemic stem cell: the Holy Grail of leukemia therapy von Misaghian, N, Ligresti, G, Steelman, L S, Bertrand, F E, Bäsecke, J, Libra, M, Nicoletti, F, Stivala, F, Milella, M, Tafuri, A, Cervello, M, Martelli, A M, McCubrey, J A

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JAK STAT, Raf MEK ERK, PI3K Akt and BCR-ABL in cell cycle progression and leukemogenesis von Steelman, L S, Pohnert, S C, Shelton, J G, Franklin, R A, Bertrand, F E, McCubrey, J A

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Involvement of PI3K Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy von Chang, F, Lee, J T, Navolanic, P M, Steelman, L S, Shelton, J G, Blalock, W L, Franklin, R A, McCubrey, J A

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Contributions of the Raf MEK ERK, PI3K PTEN Akt mTOR and Jak STAT pathways to leukemia von Steelman, L S, Abrams, S L, Whelan, J, Bertrand, F E, Ludwig, D E, Bäsecke, J, Libra, M, Stivala, F, Milella, M, Tafuri, A, Lunghi, P, Bonati, A, Martelli, A M, McCubrey, J A

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Targeting survival cascades induced by activation of Ras Raf MEK ERK, PI3K PTEN Akt mTOR and Jak STAT pathways for effective leukemia therapy von McCubrey, J A, Steelman, L S, Abrams, S L, Bertrand, F E, Ludwig, D E, Bäsecke, J, Libra, M, Stivala, F, Milella, M, Tafuri, A, Lunghi, P, Bonati, A, Martelli, A M

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Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors von Steelman, L S, Navolanic, P M, Sokolosky, M L, Taylor, J R, Lehmann, B D, Chappell, W H, Abrams, S L, Wong, E W T, Stadelman, K M, Terrian, D M, Leslie, N R, Martelli, A M, Stivala, F, Libra, M, Franklin, R A, McCubrey, J A

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Involvement of p53 and Raf MEK ERK pathways in hematopoietic drug resistance von McCubrey, J A, Abrams, S L, Ligresti, G, Misaghian, N, Wong, E W T, Steelman, L S, Bäsecke, J, Troppmair, J, Libra, M, Nicoletti, F, Molton, S, McMahon, M, Evangelisti, C, Martelli, A M

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Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention von McCubrey, J A, Steelman, L S, Bertrand, F E, Davis, N M, Abrams, S L, Montalto, G, D'Assoro, A B, Libra, M, Nicoletti, F, Maestro, R, Basecke, J, Cocco, L, Cervello, M, Martelli, A M

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Synergy between an IGF-1R antibody and Raf MEK ERK and PI3K Akt mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells von BERTRAND, F. E, STEELMAN, L. S, CHAPPELL, W. H, ABRAMS, S. L, SHELTON, J. G, WHITE, E. R, LUDWIG, D. L, MCCUBREY, J. A

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Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells : possible sites for intervention with anti-neoplastic drugs von BLALOCK, W. L, WEINSTEIN-OPPENHEIMER, C, CHANG, F, HOYLE, P. E, WANG, X.-Y, ALGATE, P. A, FRANKLIN, R. A, OBERHAUS, S. M, STEELMAN, L. S, MCCUBREY, J. A

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Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells von MCCUBREY, J. A, STEELMAN, L. S, HOYLE, P. E, BLALOCK, W. L, WEINSTEIN-OPPENHEIMER, C, FRANKLIN, R. A, CHERWINSKI, H, BOSCH, E, MCMAHON, M

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Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation von Shelton, J G, Moye, P W, Steelman, L S, Blalock, W L, Lee, J T, Franklin, R A, McMahon, M, McCubrey, J A

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Requirement for the PI3K Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia von Blalock, W L, Navolanic, P M, Steelman, L S, Shelton, J G, Moye, P W, Lee, J T, Franklin, R A, Mirza, A, McMahon, M, White, M K, McCubrey, J A

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Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism von HOYLE, P. E, MOYE, P. W, STEELMAN, L. S, BLALOCK, W. L, FRANKLIN, R. A, PEARCE, M, CHERWINSKI, H, BOSCH, E, MCMAHON, M, MCCUBREY, J. A

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Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells von BLALOCK, W. L, MOYE, P. W, CHANG, F, PEARCE, M, STEELMAN, L. S, MCMAHON, M, MCCUBREY, J. A

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A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells von BLALOCK, W. L, PEARCE, M, STEELMAN, L. S, FRANKLIN, R. A, MCCARTHY, S. A, CHERWINSKI, H, MCMAHON, M, MCCUBREY, J. A

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Effects of inducible mek1 activation on the cytokine dependency of lymphoid cells von BLALOCK, W. L, PEARCE, M, CHANG, F, LEE, J. T, POHNERT, S. C, BURROWS, C, STEELMAN, L. S, FRANKLIN, R. A, MCMAHON, M, MCCUBREY, J. A

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