A targeted amplicon next-generation sequencing assay for tryptase genotyping to support personalized therapy in mast cell-related disorders von Li, Olga, Hackney, Jason A, Choy, David F, Chang, Diana, Nersesian, Rhea, Staton, Tracy L, Cai, Fang, Toghi Eshghi, Shadi

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A whole genome sequencing study of moderate to severe asthma identifies a lung function locus associated with asthma risk von Chang, Diana, Hunkapiller, Julie, Bhangale, Tushar, Reeder, Jens, Mukhyala, Kiran, Tom, Jennifer, Cowgill, Amy, Vogel, Jan, Forrest, William F., Khan, Zia, Stockwell, Amy, McCarthy, Mark I., Staton, Tracy L., Olsson, Julie, Holweg, Cecile T. J., Cheung, Dorothy S., Chen, Hubert, Brauer, Matthew J., Graham, Robert R., Behrens, Timothy, Wilson, Mark S., Arron, Joseph R., Choy, David F., Yaspan, Brian L.

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A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibod... von Staton, Tracy L, Peng, Kun, Owen, Ryan, Choy, David F, Cabanski, Christopher R, Fong, Alice, Brunstein, Flavia, Alatsis, Kathila R, Chen, Hubert

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Seasonal Variability of Severe Asthma Exacerbations and Clinical Benefit from Lebrikizumab von Staton, Tracy L., PhD, Arron, Joseph R., MD, PhD, Olsson, Julie, MD, MS, Holweg, Cécile TJ., PhD, Matthews, John G., MB, BS, PhD, Choy, David F., BS

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A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma von Rymut, Sharon M., Henderson, Lindsay M., Poon, Victor, Staton, Tracy L., Cai, Fang, Sukumaran, Siddharth, Rhee, Horace, Owen, Ryan, Ramanujan, Saroja, Yoshida, Kenta

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Dose‐dependent inactivation of airway tryptase with a novel dissociating anti‐tryptase antibody (MTPS9579A) in healthy participants: A randomized trial von Rymut, Sharon M., Sukumaran, Siddharth, Sperinde, Gizette, Bremer, Meire, Galanter, Joshua, Yoshida, Kenta, Smith, Jordan, Banerjee, Prajna, Sverkos, Viyia, Cai, Fang, Steffen, Verena, Henderson, Lindsay M., Rhee, Horace, Belloni, Paula N., Lin, Joseph H., Staton, Tracy L.

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Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: A randomized clinical trial von Kelsen, Steven G., Agache, Ioana O., Soong, Weily, Israel, Elliot, Chupp, Geoffrey L., Cheung, Dorothy S., Theess, Wiebke, Yang, Xiaoying, Staton, Tracy L., Choy, David F., Fong, Alice, Dash, Ajit, Dolton, Michael, Pappu, Rajita, Brightling, Christopher E.

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Development of a multi-matrix LC–MS/MS method for urea quantitation and its application in human respiratory disease studies von Wang, Jianshuang, Gao, Yang, Dorshorst, Drew W., Cai, Fang, Bremer, Meire, Milanowski, Dennis, Staton, Tracy L., Cape, Stephanie S., Dean, Brian, Ding, Xiao

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Role for CXCR6 in Recruitment of Activated CD8+ Lymphocytes to Inflamed Liver von Sato, Tohru, Thorlacius, Henrik, Johnston, Brent, Staton, Tracy L, Xiang, Wenkai, Littman, Dan R, Butcher, Eugene C

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CD8 + recent thymic emigrants home to and efficiently repopulate the small intestine epithelium von Butcher, Eugene C, Staton, Tracy L, Habtezion, Aida, Winslow, Monte M, Sato, Tohru, Love, Paul E

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Seasonal variability of lung function and Asthma Quality of Life Questionnaire Scores in adults with uncontrolled asthma von N Bauer, Rebecca, Yang, Xiaoying, L Staton, Tracy, Olsson, Julie, Holweg, Cecile T J, R Arron, Joseph, Matthews, John G, Choy, David F

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma von Rhee, Horace, Henderson, Lindsay M., Bauer, Rebecca N., Wong, Kit, Staton, Tracy L., Choy, David F., Banerjee, Prajna, Poon, Victor, Yoshida, Kenta, Chen, Chen, Long, Keyi, Sperinde, Gizette, Laing, Steven T., Jones, Nicholas S., Glickstein, Sara B., Dayal, Parul, Fong, Alice, Dash, Ajit, Pulka, Grazyna, Leaker, Brian, Singh, Dave, Bradding, Peter

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Selective role of calcineurin in haematopoiesis and lymphopoiesis von Gallo, Elena M, Ho, Lena, Winslow, Monte M, Staton, Tracy L, Crabtree, Gerald R

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iNKT Cells Require CCR4 to Localize to the Airways and to Induce Airway Hyperreactivity von Meyer, Everett H, Wurbel, Marc-Andre, Staton, Tracy L, Pichavant, Muriel, Kan, Matthew J, Savage, Paul B, DeKruyff, Rosemarie H, Butcher, Eugene C, Campbell, James J, Umetsu, Dale T

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Measurement of IL-17AA and IL-17FF as Pharmacodynamic Biomarkers to Demonstrate Target Engagement in the Phase I Study of MCAF5352A von Peng, Kun, Wang, Yehong, Siradze, Ketevan, Erickson, Rich, Fischer, Saloumeh K., Staton, Tracy L.

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The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells von Glimcher, Laurie H, Lazarevic, Vanja, Zullo, Alfred J, Gallo, Elena M, Crabtree, Gerald R, Staton, Tracy L, Schweitzer, Michelle N

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Biomarkers in the clinical development of asthma therapies von Staton, Tracy L, Choy, David F, Arron, Joseph R

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma von Maun, Henry R., Jackman, Janet K., Choy, David F., Loyet, Kelly M., Staton, Tracy L., Jia, Guiquan, Dressen, Amy, Hackney, Jason A., Bremer, Meire, Walters, Benjamin T., Vij, Rajesh, Chen, Xiaocheng, Trivedi, Neil N., Morando, Ashley, Lipari, Michael T., Franke, Yvonne, Wu, Xiumin, Zhang, Juan, Liu, John, Wu, Ping, Chang, Diana, Orozco, Luz D., Christensen, Erin, Wong, Manda, Corpuz, Racquel, Hang, Julie Q., Lutman, Jeff, Sukumaran, Siddharth, Wu, Yan, Ubhayakar, Savita, Liang, Xiaorong, Schwartz, Lawrence B., Babina, Magda, Woodruff, Prescott G., Fahy, John V., Ahuja, Rahul, Caughey, George H., Kusi, Aija, Dennis, Mark S., Eigenbrot, Charles, Kirchhofer, Daniel, Austin, Cary D., Wu, Lawren C., Koerber, James T., Lee, Wyne P., Yaspan, Brian L., Alatsis, Kathila R., Arron, Joseph R., Lazarus, Robert A., Yi, Tangsheng

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Dampening of death pathways by schnurri-2 is essential for T-cell development von Staton, Tracy L., Lazarevic, Vanja, Jones, Dallas C., Lanser, Amanda J., Takagi, Tsuyoshi, Ishii, Shunsuke, Glimcher, Laurie H.

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