Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo von Stancu, Ilie-Cosmin, Cremers, Niels, Vanrusselt, Hannah, Couturier, Julien, Vanoosthuyse, Alexandre, Kessels, Sofie, Lodder, Chritica, Brône, Bert, Huaux, François, Octave, Jean-Noël, Terwel, Dick, Dewachter, Ilse

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Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo von Vasconcelos, Bruno, Stancu, Ilie-Cosmin, Buist, Arjan, Bird, Matthew, Wang, Peng, Vanoosthuyse, Alexandre, Van Kolen, Kristof, Verheyen, An, Kienlen-Campard, Pascal, Octave, Jean-Noël, Baatsen, Peter, Moechars, Diederik, Dewachter, Ilse

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Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice von Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen, Van Acker, Nathalie, Kemp, John A, Mercken, Marc, Brunden, Kurt R, Trojanowski, John Q, Dewachter, Ilse, Lee, Virginia M.Y, Moechars, Diederik

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Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice von Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Ris, Laurence, Wang, Peng, Villers, Agnès, Peeraer, Eve, Buist, Arjan, Terwel, Dick, Baatsen, Peter, Oyelami, Tutu, Pierrot, Nathalie, Casteels, Cindy, Bormans, Guy, Kienlen-Campard, Pascal, Octave, Jean-Nöel, Moechars, Diederik, Dewachter, Ilse

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Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease von Stancu, Ilie‐Cosmin, Ris, Laurence, Vasconcelos, Bruno, Marinangeli, Claudia, Goeminne, Léonie, Laporte, Vincent, Haylani, Laetitia E., Couturier, Julien, Schakman, Olivier, Gailly, Philippe, Pierrot, Nathalie, Kienlen‐Campard, Pascal, Octave, Jean‐Noël, Dewachter, Ilse

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Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism von Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Terwel, Dick, Dewachter, Ilse

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Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau von McInnes, Joseph, Wierda, Keimpe, Snellinx, An, Bounti, Laura, Wang, Yu-Chun, Stancu, Ilie-Cosmin, Apóstolo, Nuno, Gevaert, Kris, Dewachter, Ilse, Spires-Jones, Tara L., De Strooper, Bart, De Wit, Joris, Zhou, Lujia, Verstreken, Patrik

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Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo von Wang, Peng, Joberty, Gerard, Buist, Arjan, Vanoosthuyse, Alexandre, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Pierrot, Nathalie, Faelth-Savitski, Maria, Kienlen-Campard, Pascal, Octave, Jean-Noël, Bantscheff, Marcus, Drewes, Gerard, Moechars, Diederik, Dewachter, Ilse

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Blood-based Aβ42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new avenues... von Botella Lucena, Pablo, Vanherle, Sarah, Lodder, Chritica, Gutiérrez de Ravé, Manuel, Stancu, Ilie-Cosmin, Lambrichts, Ivo, Vangheluwe, Riet, Bruffaerts, Rose, Dewachter, Ilse

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Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease von Couturier, Julien, Stancu, Ilie-Cosmin, Schakman, Olivier, Pierrot, Nathalie, Huaux, François, Kienlen-Campard, Pascal, Dewachter, Ilse, Octave, Jean-Noël

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CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia von Lodder, Chritica, Scheyltjens, Isabelle, Stancu, Ilie Cosmin, Botella Lucena, Pablo, Gutiérrez de Ravé, Manuel, Vanherle, Sarah, Vanmierlo, Tim, Cremers, Niels, Vanrusselt, Hannah, Brône, Bert, Hanseeuw, Bernard, Octave, Jean-Noël, Bottelbergs, Astrid, Movahedi, Kiavash, Dewachter, Ilse

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IDENTIFICATION OF NOVEL TARGETS FOR INHIBITING PRION-LIKE SEEDING AND PROPAGATION OF TAU PATHOLOGY IN VITRO AND IN VIVO von Dewachter, Ilse, Stancu, Ilie-Cosmin, Vanoosthuyse, Alexandre, Buist, Arjan, Vasconcelos, Bruno, Wang, Peng, Kienlen-Campard, Pascal, Octave, Jean-Noël, Moechars, Diederik

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Sex-regulated gene dosage effect of PPARα on synaptic plasticity von Pierrot, Nathalie, Ris, Laurence, Stancu, Ilie-Cosmin, Doshina, Anna, Ribeiro, Floriane, Tyteca, Donatienne, Baugé, Eric, Lalloyer, Fanny, Malong, Liza, Schakman, Olivier, Leroy, Karelle, Kienlen-Campard, Pascal, Gailly, Philippe, Brion, Jean-Pierre, Dewachter, Ilse, Staels, Bart, Octave, Jean-Noël

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Improvement of synaptic plasticity by pharmacological activation of RXR nuclear receptors is PPARα dependent von PIERROT, Nathalie, Ris, Laurence, STANCU, Ilie-Cosmin STANCU, Leroy, Karelle, Kienlen-Campard, Pascal, Gailly, Philippe, Brion, Jean-Pierre, Dewachter, Ilse, Octave, Jean-Noël

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The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model von Stancu, Ilie Cosmin, Lodder, Chritica, Botella Lucena, Pablo, Vanherle, Sarah, Gutiérrez de Ravé, Manuel, Terwel, Dick, Bottelbergs, Astrid, Dewachter, Ilse

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Blood-based A[beta]42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new av... von Botella Lucena, Pablo, Vanherle, Sarah, Lodder, Chritica, Gutiérrez de Ravé, Manuel, Stancu, Ilie-Cosmin, Lambrichts, Ivo, Vangheluwe, Riet

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The NLRP3 inflammasome modulates tau pathology and neurodegeneration in a tauopathy model von Stancu, Ilie Cosmin, Lodder, Chritica, Lucena, Pablo Botella, Vanherle, Sarah, de Rave, Manuel Gutierrez, Terwel, Dick, Bottelbergs, Astrid, Dewachter, Ilse

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Blood-based A beta 42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new av... von Lucena, Pablo Botella, Vanherle, Sarah, Lodder, Chritica, de Rave, Manuel Gutierrez, Stancu, Ilie-Cosmin, Lambrichts, Ivo, Vangheluwe, Riet, Bruffaerts, Rose, Dewachter, Ilse

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Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau von McInnes, Joseph, Wierda, Keimpe, Snellinx, An, Bounti, Laura, Wang, Yu-Chun, Stancu, Ilie-Cosmin, Apóstolo, Nuno, Gevaert, Kris, Dewachter, Ilse, Spires-Jones, Tara L, De Strooper, Bart, de Wit, Joris, Zhou, Lujia, Verstreken, Patrik

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IDENTIFICATION AND VALIDATION OF TAU-MODIFIERS, IDENTIFIED BY UNBIASED GENOME WIDE APPROACHES, USING AAV-BASED APPROACHES IN TAU TRANSGENIC MICE von Wang, Peng, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Bird, Matthew, Vanoosthuyse, Alexandre, Moechars, Diederik, Dewachter, Ilse

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