Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory von Weinfurt, Kevin P, Hernandez, Adrian F, Coronado, Gloria D, DeBar, Lynn L, Dember, Laura M, Green, Beverly B, Heagerty, Patrick J, Huang, Susan S, James, Kathryn T, Jarvik, Jeffrey G, Larson, Eric B, Mor, Vincent, Platt, Richard, Rosenthal, Gary E, Septimus, Edward J, Simon, Gregory E, Staman, Karen L, Sugarman, Jeremy, Vazquez, Miguel, Zatzick, Douglas, Curtis, Lesley H

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Monitoring and responding to signals of suicidal ideation in pragmatic clinical trials: Lessons from the GRACE trial for Chronic Sickle Cell Disease Pain von Swirsky, Eric S., Boyd, Andrew D., Gu, Carol, Burke, Larisa A., Doorenbos, Ardith Z., Ezenwa, Miriam O., Knisely, Mitchell R., Leigh, Jonathan W., Li, Hongjin, Mandernach, Molly W., Molokie, Robert E., Patil, Crystal L., Steffen, Alana D., Shah, Nirmish, deMartelly, Victoria A., Staman, Karen L., Schlaeger, Judith M.

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Potential bias and lack of generalizability in electronic health record data: reflections on health equity from the National Institutes of Health Pragmatic Trials Collaboratory von Boyd, Andrew D, Gonzalez-Guarda, Rosa, Lawrence, Katharine, Patil, Crystal L, Ezenwa, Miriam O, O’Brien, Emily C, Paek, Hyung, Braciszewski, Jordan M, Adeyemi, Oluwaseun, Cuthel, Allison M, Darby, Juanita E, Zigler, Christina K, Ho, P Michael, Faurot, Keturah R, Staman, Karen L, Leigh, Jonathan W, Dailey, Dana L, Cheville, Andrea, Del Fiol, Guilherme, Knisely, Mitchell R, Grudzen, Corita R, Marsolo, Keith, Richesson, Rachel L, Schlaeger, Judith M

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Impact of electronic health record updates and changes on the delivery and monitoring of interventions in embedded pragmatic clinical trials von Marsolo, Keith A., Cheville, Andrea, Melnick, Edward R., Jarvik, Jeffrey G., Simon, Gregory E., Sluka, Kathleen A., Crofford, Leslie J., Staman, Karen L., Richesson, Rachel L., Schlaeger, Judith M., Curtis, Lesley H.

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Oversight on the borderline: Quality improvement and pragmatic research von Finkelstein, Jonathan A, Brickman, Andrew L, Capron, Alexander, Ford, Daniel E, Gombosev, Adrijana, Greene, Sarah M, Iafrate, R Peter, Kolaczkowski, Laura, Pallin, Sarah C, Pletcher, Mark J, Staman, Karen L, Vazquez, Miguel A, Sugarman, Jeremy

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Intervention delivery for embedded pragmatic clinical trials: Development of a tool to measure complexity von Staman, Karen L., Check, Devon K., Zatzick, Doug, Mor, Vincent, Fritz, Julie M., Sluka, Kathleen, DeBar, Lynn L., Jarvik, Jeffrey G., Volandes, Angelo, Coronado, Gloria D., Chambers, David A., Weinfurt, Kevin P., George, Steven Z.

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Collecting patient-reported outcome measures in the electronic health record: Lessons from the NIH pragmatic trials Collaboratory von Zigler, Christina K., Adeyemi, Oluwaseun, Boyd, Andrew D., Braciszewski, Jordan M., Cheville, Andrea, Cuthel, Allison M., Dailey, Dana L., Del Fiol, Guilherme, Ezenwa, Miriam O., Faurot, Keturah R., Justice, Morgan, Ho, P. Michael, Lawrence, Katherine, Marsolo, Keith, Patil, Crystal L., Paek, Hyung, Richesson, Rachel L., Staman, Karen L., Schlaeger, Judith M., O'Brien, Emily C.

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Responding to signals of mental and behavioral health risk in pragmatic clinical trials: Ethical obligations in a healthcare ecosystem von Ali, Joseph, Morain, Stephanie R., O'Rourke, P. Pearl, Wilfond, Benjamin, O'Brien, Emily C., Zigler, Christina K., Staman, Karen L., Weinfurt, Kevin P., Sugarman, Jeremy

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Ethical responsibilities toward indirect and collateral participants in pragmatic clinical trials von Smalley, Jaye Bea, Merritt, Maria W, Al-Khatib, Sana M, McCall, Debbe, Staman, Karen L, Stepnowsky, Carl

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Privacy and confidentiality in pragmatic clinical trials von McGraw, Deven, Greene, Sarah M, Miner, Caroline S, Staman, Karen L, Welch, Mary Jane, Rubel, Alan

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Addressing guideline and policy changes during pragmatic clinical trials von Curtis, Lesley H, Dember, Laura M, Vazquez, Miguel A, Murray, David, DeBar, Lynn, Staman, Karen L, Septimus, Edward, Mor, Vincent, Volandes, Angelo, Wells, Barbara L, Huang, Susan S, Green, Beverly B, Coronado, Gloria, Meyers, Catherine M, Tuzzio, Leah, Hernandez, Adrian F, Sugarman, Jeremy

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Contemporary utilization and outcomes of intra-aortic balloon counterpulsation in acute myocardial infarction: The Benchmark Registry von STONE, Grgg W, OHMAN, E. Magnus, FERGUSON, James J, MILLER, Michael F, JOSEPH, Debra L, CHRISTENSON, Jan T, COHEN, Marc, URBAN, Philip M, REDDY, Ramachandra C, FREEDMAN, Robert J, STAMAN, Karen L

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Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies von Tuzzio, Leah, Meyers, Catherine M., Dember, Laura M., Grudzen, Corita R., Melnick, Edward R., Staman, Karen L., Huang, Susan S., Richards, Julie, DeBar, Lynn, Vazquez, Miguel A., Green, Beverly B., Coronado, Gloria D., Jarvik, Jeffrey G., Braciszewski, Jordan, Ho, P. Michael, Wells, Barbara L., James, Kathryn, Toto, Robert, D'Onofrio, Gail, Volandes, Angelo, Kuklinski, Margaret R., Catalano, Richard F., Sterling, Stacy A., Morse, Erica F., Curtis, Lesley, Larson, Eric B.

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Induction and/or Selection of Phenolic Acid-Utilizing Bulk-Soil and Rhizosphere Bacteria and Their Influence on Phenolic Acid Phytotoxicity von Blum, Udo, Staman, Karen L, Flint, Laura J, Shafer, Steven R

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Contemporary utilization and outcomes of intra-aortic balloon counterpulsation in acute myocardial infarction von Stone, Gregg W, Ohman, E.Magnus, Miller, Michael F, Joseph, Debra L, Christenson, Jan T, Cohen, Marc, Urban, Philip M, Reddy, Ramachandra C, Freedman, Robert J, Staman, Karen L, Ferguson, James J

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Induction and/or selection of phenolic acid-utilizing bulk-soil and rhizosphere bacteria and their influence on phenolic acid phytotoxicity: Allelopathy von BLUM, Udo, STAMAN, Karen L, FLINT, Laura J, SHAFER, Steven R

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Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory von Weinfurt, Kevin P, Hernandez, Adrian F, Coronado, Gloria D, DeBar, Lynn L, Dember, Laura M, Green, Beverly B, Heagerty, Patrick J, Huang, Susan S, James, Kathryn T, Jarvik, Jeffrey G, Larson, Eric B, Mor, Vincent, Platt, Richard, Rosenthal, Gary E, Septimus, Edward J, Simon, Gregory E, Staman, Karen L, Sugarman, Jeremy, Vazquez, Miguel, Zatzick, Douglas, Curtis, Lesley H

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Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory von Richesson, Rachel L, Marsolo, Keith S, Douthit, Brian J, Staman, Karen, Ho, P Michael, Dailey, Dana, Boyd, Andrew D, McTigue, Kathleen M, Ezenwa, Miriam O, Schlaeger, Judith M, Patil, Crystal L, Faurot, Keturah R, Tuzzio, Leah, Larson, Eric B, O’Brien, Emily C, Zigler, Christina K, Lakin, Joshua R, Pressman, Alice R, Braciszewski, Jordan M, Grudzen, Corita, Fiol, Guilherme Del

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Equity and bias in electronic health records data von Boyd, Andrew D., Gonzalez-Guarda, Rosa, Lawrence, Katharine, Patil, Crystal L., Ezenwa, Miriam O., O'Brien, Emily C., Paek, Hyung, Braciszewski, Jordan M., Adeyemi, Oluwaseun, Cuthel, Allison M., Darby, Juanita E., Zigler, Christina K., Ho, P. Michael, Faurot, Keturah R., Staman, Karen, Leigh, Jonathan W., Dailey, Dana L., Cheville, Andrea, Del Fiol, Guilherme, Knisely, Mitchell R., Marsolo, Keith, Richesson, Rachel L., Schlaeger, Judith M.

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Special Section on Patient-Reported Outcomes and Informatics: Collection of Patient-Reported Outcome Measures in Rural and Underserved Populations von Cheville, Andrea L., Patil, Crystal, Boyd, Andrew D, Crofford, Leslie, Dailey, Dana, de Martelly, Victoria, Del Fiol, Guilherme, Ezenwa, Miriam, Faurot, Keturah, Knisely, Mitch, McLeod, Kaitlyn, Morone, Natalia, O’Brien, Emily, Gonzalez-Guarda, Rosa, Sluka, Kathleen, Staman, Karen, Thackeray, Anne, Zigler, Christina, Schlaeger, Judith

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