Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex von Staker, Bart L, Feese, Michael D, Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B

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The Mechanism of Topoisomerase I Poisoning by a Camptothecin Analog von Staker, Bart L., Hjerrild, Kathryn, Feese, Michael D., Behnke, Craig A., Burgin, Alex B., Stewart, Lance

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Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations von Chrencik, Jill E, Staker, Bart L, Burgin, Alex B, Pourquier, Philippe, Pommier, Yves, Stewart, Lance, Redinbo, Matthew R

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RNA Methylation under Heat Shock Control von Bügl, Hans, Fauman, Eric B., Staker, Bart L., Zheng, Fuzhong, Kushner, Sidney R., Saper, Mark A., Bardwell, James C.A., Jakob, Ursula

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Active Site in RrmJ, a Heat Shock-induced Methyltransferase von Hager, Jutta, Staker, Bart L, Bugl, Hans, Jakob, Ursula

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Structure of Hsp15 reveals a novel RNA-binding motif von Staker, Bart L., Korber, Philipp, Bardwell, James C. A., Saper, Mark A.

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Structure of aldose reductase from Giardia lamblia von Ferrell, M., Abendroth, J., Zhang, Y., Sankaran, B., Edwards, T. E., Staker, B. L., Van Voorhis, W. C., Stewart, L. J., Myler, P. J.

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Effect of pentoxifylline on radiation-induced lung and skin toxicity in rats von Koh, Wui-Jin, Stelzer, Keith J., Peterson, Lanell M., Staker, Bart L., Ward, William F., Russell, Kenneth J., Griffin, Thomas W.

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex von Marchand, Christophe, Antony, Smitha, Kohn, Kurt W, Cushman, Mark, Ioanoviciu, Alexandra, Staker, Bart L, Burgin, Alex B, Stewart, Lance, Pommier, Yves

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Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhi... von Ioanoviciu, Alexandra, Antony, Smitha, Pommier, Yves, Staker, Bart L, Stewart, Lance, Cushman, Mark

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Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): Profound asymmetry in the crystal structure of the ‘open’ state von Buchko, Garry W., Robinson, Howard, Abendroth, Jan, Staker, Bart L., Myler, Peter J.

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Effect of Bicarbonate on Stability of the Gallium-Transferrin Complex von Staker, Bart L, Graham, Michael M, Evans, Margaret L

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Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids von Fox, Brian M, Xiao, Xiangshu, Antony, Smitha, Kohlhagen, Glenda, Pommier, Yves, Staker, Bart L, Stewart, Lance, Cushman, Mark

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Substrate Specificity of Tyrosyl-DNA Phosphodiesterase I (Tdp1) von Raymond, Amy C., Staker, Bart L., Burgin, Alex B.

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Substrate Binding Analysis of the 23S rRNA Methyltransferase RrmJ von HAGER, Jutta, STAKER, Bart L, JAKOB, Ursula

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Structure-guided identification of resistance breaking antimalarial N-myristoyltransferase inhibitors von Schlott, AC, Mayclin, S, Reers, AR, Coburn-Flynn, O, Bell, AS, Green, J, Knuepfer, E, Charter, D, Bonnert, R, Campo, B, Burrows, J, Lyons-Abbott, S, Staker, BL, Chung, C-W, Myler, PJ, Fidock, DA, Tate, EW, Holder, AA

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Multiple inhibitor co-crystal structures of the human topoisomerase I covalent DNA complex bound to a series of structurally diverse anti-cancer compounds von Staker, B. L., Feese, M. D., Zembower, D., Stewart, L., Burgin, A. B.

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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis von Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety von Burgin, Alex B, Gurney, Mark E, Magnusson, Olafur T, Singh, Jasbir, Witte, Pam, Staker, Bart L, Bjornsson, Jon M, Thorsteinsdottir, Margret, Hrafnsdottir, Sigrun, Hagen, Timothy, Kiselyov, Alex S, Stewart, Lance J

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Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis von Reif, Karin, Currie, Kevin S, Di Paolo, Julie A, Huang, Tao, Balazs, Mercedesz, Barbosa, James, Barck, Kai H, Bravo, Brandon J, Carano, Richard A D, Darrow, James, Davies, Douglas R, DeForge, Laura E, Diehl, Lauri, Ferrando, Ronald, Gallion, Steven L, Giannetti, Anthony M, Gribling, Peter, Hurez, Vincent, Hymowitz, Sarah G, Jones, Randall, Kropf, Jeffrey E, Lee, Wyne P, Maciejewski, Patricia M, Mitchell, Scott A, Rong, Hong, Staker, Bart L, Whitney, J Andrew, Yeh, Sherry, Young, Wendy B, Yu, Christine, Zhang, Juan

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