Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) von Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K

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Discovery of Alogliptin:  A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV von Feng, Jun, Zhang, Zhiyuan, Wallace, Michael B, Stafford, Jeffrey A, Kaldor, Stephen W, Kassel, Daniel B, Navre, Marc, Shi, Lihong, Skene, Robert J, Asakawa, Tomoko, Takeuchi, Koji, Xu, Rongda, Webb, David R, Gwaltney, Stephen L

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JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders von Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.

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Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity von Kumar, Rakesh, Knick, Victoria B, Rudolph, Sharon K, Johnson, Jennifer H, Crosby, Renae M, Crouthamel, Ming-Chih, Hopper, Teresa M, Miller, Charles G, Harrington, Laura E, Onori, James A, Mullin, Robert J, Gilmer, Tona M, Truesdale, Anne T, Epperly, Andrea H, Boloor, Amogh, Stafford, Jeffrey A, Luttrell, Deirdre K, Cheung, Mui

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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor R... von Harris, Philip A, Boloor, Amogh, Cheung, Mui, Kumar, Rakesh, Crosby, Renae M, Davis-Ward, Ronda G, Epperly, Andrea H, Hinkle, Kevin W, Hunter, Robert N, Johnson, Jennifer H, Knick, Victoria B, Laudeman, Christopher P, Luttrell, Deirdre K, Mook, Robert A, Nolte, Robert T, Rudolph, Sharon K, Szewczyk, Jerzy R, Truesdale, Anne T, Veal, James M, Wang, Liping, Stafford, Jeffrey A

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Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders von Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.

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Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV von Zhang, Zhiyuan, Wallace, Michael B, Feng, Jun, Stafford, Jeffrey A, Skene, Robert J, Shi, Lihong, Lee, Bumsup, Aertgeerts, Kathleen, Jennings, Andy, Xu, Rongda, Kassel, Daniel B, Kaldor, Stephen W, Navre, Marc, Webb, David R, Gwaltney, Stephen L

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Overcoming Preclinical Safety Obstacles to Discover (S)‑N‑((1,2,3,5,6,7-Hexahydro‑s‑indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro‑5H‑pyrazolo[5,1‑b][1,3]oxazine-3-sulfonamide... von McBride, Christopher, Trzoss, Lynnie, Povero, Davide, Lazic, Milos, Ambrus-Aikelin, Geza, Santini, Angelina, Pranadinata, Rama, Bain, Gretchen, Stansfield, Ryan, Stafford, Jeffrey A., Veal, James, Takahashi, Ryan, Ly, Justin, Chen, Shu, Liu, Liling, Nespi, Marika, Blake, Robert, Katewa, Arna, Kleinheinz, Tracy, Sujatha-Bhaskar, Swathi, Ramamoorthi, Nandhini, Sims, Jessica, McKenzie, Brent, Chen, Mark, Ultsch, Mark, Johnson, Matthew, Murray, Jeremy, Ciferri, Claudio, Staben, Steven T., Townsend, Michael J., Stivala, Craig E.

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KDM4 Inhibition Targets Breast Cancer Stem-like Cells von Metzger, Eric, Stepputtis, Stella S, Strietz, Juliane, Preca, Bogdan-Tiberius, Urban, Sylvia, Willmann, Dominica, Allen, Anita, Zenk, Fides, Iovino, Nicola, Bronsert, Peter, Proske, Amelie, Follo, Marie, Boerries, Melanie, Stickeler, Elmar, Xu, Jiangchun, Wallace, Michael B, Stafford, Jeffrey A, Kanouni, Toufike, Maurer, Jochen, Schüle, Roland

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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepat... von Povero, Davide, Lazic, Milos, McBride, Christopher, Ambrus-Aikelin, Geza, Stansfield, Ryan, Johnson, Casey D, Santini, Angelina M, Pranadinata, Rama F, McGeough, Matthew D, Stafford, Jeffrey A, Hoffman, Hal M, Feldstein, Ariel E, Veal, James M, Bain, Gretchen

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Structure-based design and discovery of potent and selective KDM5 inhibitors von Nie, Zhe, Shi, Lihong, Lai, Chon, O'Connell, Shawn M., Xu, Jiangchun, Stansfield, Ryan K., Hosfield, David J., Veal, James M., Stafford, Jeffrey A.

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CNS 7056: a novel ultra-short-acting Benzodiazepine von Kilpatrick, Gavin J, McIntyre, Margaret S, Cox, Richard F, Stafford, Jeffrey A, Pacofsky, Gregory J, Lovell, Gwyer G, Wiard, Robert P, Feldman, Paul L, Collins, Holly, Waszczak, Barbara L, Tilbrook, Gary S

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Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors von Nie, Zhe, Shi, Lihong, Lai, Chon, Severin, Christophe, Xu, Jiangchun, Del Rosario, Joselyn R., Stansfield, Ryan K., Cho, Robert W., Kanouni, Toufike, Veal, James M., Stafford, Jeffrey A., Chen, Young K.

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Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors von Bennett, Michael J., Wu, Yiqin, Boloor, Amogh, Matuszkiewicz, Jennifer, O'Connell, Shawn M., Shi, Lihong, Stansfield, Ryan K., Del Rosario, Joselyn R., Veal, James M., Hosfield, David J., Xu, Jiangchun, Kaldor, Stephen W., Stafford, Jeffrey A., Betancort, Juan M.

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models von Chen, Young K, Bonaldi, Tiziana, Cuomo, Alessandro, Del Rosario, Joselyn R, Hosfield, David J, Kanouni, Toufike, Kao, Shih-chu, Lai, Chon, Lobo, Neethan A, Matuszkiewicz, Jennifer, McGeehan, Andrew, O’Connell, Shawn M, Shi, Lihong, Stafford, Jeffrey A, Stansfield, Ryan K, Veal, James M, Weiss, Michael S, Yuen, Natalie Y, Wallace, Michael B

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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase von Sammond, Douglas M., Nailor, Kristen E., Veal, James M., Nolte, Robert T., Wang, Liping, Knick, Victoria B., Rudolph, Sharon K., Truesdale, Anne T., Nartey, Eldridge N., Stafford, Jeffrey A., Kumar, Rakesh, Cheung, Mui

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Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors von Harris, Philip A, Cheung, Mui, Hunter, Robert N, Brown, Matthew L, Veal, James M, Nolte, Robert T, Wang, Liping, Liu, Wendy, Crosby, Renae M, Johnson, Jennifer H, Epperly, Andrea H, Kumar, Rakesh, Luttrell, Deirdre K, Stafford, Jeffrey A

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Efficient and Regioselective Synthesis of 2-Alkyl-2H-indazoles von Cheung, Mui, Boloor, Amogh, Stafford, Jeffrey A

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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV von Feng, Jun, Zhang, Zhiyuan, Wallace, Michael B, Stafford, Jeffrey A, Kaldor, Stephen W, Kassel, Daniel B, Navre, Marc, Shi, Lihong, Skene, Robert J, Asakawa, Tomoko, Takeuchi, Koji, Xu, Rongda, Webb, David R, Gwaltney, Stephen L

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Design and Synthesis of Conformationally Constrained Analogs of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase von Brackeen, Marcus F, Stafford, Jeffrey A, Cowan, David J, Brown, Peter J, Domanico, Paul L, Feldman, Paul L, Rose, Dudley, Strickland, Alan B, Veal, James M, Verghese, Margrith

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