Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity von Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C, Chen, Kaiwen W, Ross, Connie M, Teo, Jessica L, Gomez, Guillermo A, Holley, Caroline L, Bierschenk, Damien, Stacey, Katryn J, Yap, Alpha S, Bezbradica, Jelena S, Schroder, Kate

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The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge von Chen, Kaiwen W., Groß, Christina J., Sotomayor, Flor Vásquez, Stacey, Katryn J., Tschopp, Jurg, Sweet, Matthew J., Schroder, Kate

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Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection von Aachoui, Youssef, Sagulenko, Vitaliya, Miao, Edward A, Stacey, Katryn J

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Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex von Fu, Tian-Min, Li, Yang, Lu, Alvin, Li, Zongli, Vajjhala, Parimala R., Cruz, Anthony C., Srivastava, Devendra B., DiMaio, Frank, Penczek, Pawel A., Siegel, Richard M., Stacey, Katryn J., Egelman, Edward H., Wu, Hao

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The mammalian PYHIN gene family: phylogeny, evolution and expression von Cridland, Jasmyn A, Curley, Eva Z, Wykes, Michelle N, Schroder, Kate, Sweet, Matthew J, Roberts, Tara L, Ragan, Mark A, Kassahn, Karin S, Stacey, Katryn J

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MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography von Clabbers, Max T. B., Holmes, Susannah, Muusse, Timothy W., Vajjhala, Parimala R., Thygesen, Sara J., Malde, Alpeshkumar K., Hunter, Dominic J. B., Croll, Tristan I., Flueckiger, Leonie, Nanson, Jeffrey D., Rahaman, Md. Habibur, Aquila, Andrew, Hunter, Mark S., Liang, Mengning, Yoon, Chun Hong, Zhao, Jingjing, Zatsepin, Nadia A., Abbey, Brian, Sierecki, Emma, Gambin, Yann, Stacey, Katryn J., Darmanin, Connie, Kobe, Bostjan, Xu, Hongyi, Ve, Thomas

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Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8 von Sagulenko, Vitaliya, Vitak, Nazarii, Vajjhala, Parimala R., Vince, James E., Stacey, Katryn J.

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Bacterial membrane vesicles transport their DNA cargo into host cells von Bitto, Natalie J., Chapman, Ross, Pidot, Sacha, Costin, Adam, Lo, Camden, Choi, Jasmine, D’Cruze, Tanya, Reynolds, Eric C., Dashper, Stuart G., Turnbull, Lynne, Whitchurch, Cynthia B., Stinear, Timothy P., Stacey, Katryn J., Ferrero, Richard L.

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The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways von Vajjhala, Parimala R., Ve, Thomas, Bentham, Adam, Stacey, Katryn J., Kobe, Bostjan

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Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling von Ve, Thomas, Vajjhala, Parimala R, Hedger, Andrew, Croll, Tristan, DiMaio, Frank, Horsefield, Shane, Yu, Xiong, Lavrencic, Peter, Hassan, Zahid, Morgan, Garry P, Mansell, Ashley, Mobli, Mehdi, O'Carroll, Ailis, Chauvin, Brieuc, Gambin, Yann, Sierecki, Emma, Landsberg, Michael J, Stacey, Katryn J, Egelman, Edward H, Kobe, Bostjan

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HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA von Roberts, Tara L, Idris, Adi, Dunn, Jasmyn A, Kelly, Greg M, Burnton, Carol M, Hodgson, Samantha, Hardy, Lani L, Garceau, Valerie, Sweet, Matthew J, Ross, Ian L, Hume, David A, Stacey, Katryn J

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A broadly protective antibody that targets the flavivirus NS1 protein von Modhiran, Naphak, Song, Hao, Liu, Lidong, Bletchly, Cheryl, Brillault, Lou, Amarilla, Alberto A, Xu, Xiaoying, Qi, Jianxun, Chai, Yan, Cheung, Stacey T M, Traves, Renee, Setoh, Yin Xiang, Bibby, Summa, Scott, Connor A P, Freney, Morgan E, Newton, Natalee D, Khromykh, Alexander A, Chappell, Keith J, Muller, David A, Stacey, Katryn J, Landsberg, Michael J, Shi, Yi, Gao, George F, Young, Paul R, Watterson, Daniel

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Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming von Allam, Ramanjaneyulu, Lawlor, Kate E, Yu, Eric Chi-Wang, Mildenhall, Alison L, Moujalled, Donia M, Lewis, Rowena S, Ke, Francine, Mason, Kylie D, White, Michael J, Stacey, Katryn J, Strasser, Andreas, O'Reilly, Lorraine A, Alexander, Warren, Kile, Benjamin T, Vaux, David L, Vince, James E

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Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages von Thygesen, Sara J, Burgener, Sabrina S, Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate, Stacey, Katryn J

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IRF1 and IRF2 regulate the non‐canonical inflammasome von Thygesen, Sara J, Stacey, Katryn J

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Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6 von Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G, Young, Paul R, Stacey, Katryn J

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SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein von Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J., Khromykh, Alexander A., Chappell, Keith J., Watterson, Daniel, Woodruff, Trent M.

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Salmonella employs multiple mechanisms to subvert the TLR‐inducible zinc‐mediated antimicrobial response of human macrophages von Kapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl‐lynn Y., Peters, Kate M., Stocks, Claudia J., Phan, Minh‐Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A., Sweet, Matthew J.

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A novel flow cytometric method to assess inflammasome formation von Sester, David P, Thygesen, Sara J, Sagulenko, Vitaliya, Vajjhala, Parimala R, Cridland, Jasmyn A, Vitak, Nazarii, Chen, Kaiwen W, Osborne, Geoffrey W, Schroder, Kate, Stacey, Katryn J

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The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments von Vajjhala, Parimala R., Lu, Alvin, Brown, Darren L., Pang, Siew Wai, Sagulenko, Vitaliya, Sester, David P., Cridland, Simon O., Hill, Justine M., Schroder, Kate, Stow, Jennifer L., Wu, Hao, Stacey, Katryn J.

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