ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance von Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram

Volltext

Characterization of immune regulatory molecules B7-H4 and PD-L1 in low and high grade endometrial tumors von Bregar, Amy, Deshpande, Amit, Grange, Chris, Zi, Tong, Stall, Jennifer, Hirsch, Heather, Reeves, Jason, Sathyanarayanan, Sriram, Growdon, Whitfield B, Rueda, Bo R

Volltext

Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1) von Fang, Yanshan, Sathyanarayanan, Sriram, Sehgal, Amita

Volltext

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models von Hanson, Amanda, Elpek, Kutlu, Duong, Ellen, Shallberg, Lindsey, Fan, Martin, Johnson, Calvin, Wallace, Matthew, Mabry, George R., Sazinsky, Stephen, Pepper, Lauren, Shu, Chengyi J., Sathyanarayanan, Sriram, Zuerndorfer, Sarah, Simpson, Tyler, Gostissa, Monica, Briskin, Michael, Law, Deborah, Michaelson, Jennifer, Harvey, Christopher J.

Volltext

Posttranslational Regulation of Drosophila PERIOD Protein by Protein Phosphatase 2A von Sathyanarayanan, Sriram, Zheng, Xiangzhong, Xiao, Rui, Sehgal, Amita

Volltext

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma von Stoeck, Alexander, Lejnine, Serguei, Truong, Andrew, Pan, Li, Wang, Hongfang, Zang, Chongzhi, Yuan, Jing, Ware, Chris, MacLean, John, Garrett-Engele, Philip W, Kluk, Michael, Laskey, Jason, Haines, Brian B, Moskaluk, Christopher, Zawel, Leigh, Fawell, Stephen, Gilliland, Gary, Zhang, Theresa, Kremer, Brandon E, Knoechel, Birgit, Bernstein, Bradley E, Pear, Warren S, Liu, X Shirley, Aster, Jon C, Sathyanarayanan, Sriram

Volltext

Combination of the mTOR inhibitor ridaforolimus and the anti-IGF1R monoclonal antibody dalotuzumab: preclinical characterization and phase I clinical trial von Di Cosimo, Serena, Sathyanarayanan, Sriram, Bendell, Johanna C, Cervantes, Andrés, Stein, Mark N, Braña, Irene, Roda, Desamparados, Haines, Brian B, Zhang, Theresa, Winter, Christopher G, Jha, Sharda, Xu, Youyuan, Frazier, Jason, Klinghoffer, Richard A, Leighton-Swayze, Ann, Song, Yang, Ebbinghaus, Scot, Baselga, José

Volltext

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop von Kume, Kazuhiko, Zylka, Mark J, Sriram, Sathyanarayanan, Shearman, Lauren P, Weaver, David R, Jin, Xiaowei, Maywood, Elizabeth S, Hastings, Michael H, Reppert, Steven M

Volltext

Interacting Molecular Loops in the Mammalian Circadian Clock von Shearman, Lauren P., Sriram, Sathyanarayanan, Weaver, David R., Maywood, Elizabeth S., Chaves, Inẽs, Zheng, Binhai, Kume, Kazuhiko, Lee, Cheng Chi, Gijsbertus T. J. van der Horst, Hastings, Michael H., Reppert, Steven M.

Volltext

Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen von Sathyanarayanan, Sriram, Zheng, Xiangzhong, Kumar, Shailesh, Chen, Chun-Hong, Chen, Dechun, Hay, Bruce, Sehgal, Amita

Volltext

761 exoSTING demonstrates potent anti-tumor activity in a mouse model of leptomeningeal disease von Feng, Xudong, Lin, John, Jang, Su Chul, Lule, Sevda, Sanchez-Jauregui, Paloma, Kirwin, Katherine, Zi, Tong, Kasera, Samuel, Siso, Silvia, Zhang, Kelvin, Patel, Shil, Sathyanarayanan, Sriram, Economides, Kyriakos, Broom, Wendy

Volltext

703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo von Kauke, Monique, Ross, Nikki, Burzyn, Dalia, Martin, Shelly, Xu, Ke, Lewis, Nuruddeen, Leng, Charan, Jang, Su Chul, McCoy, Christine, Yu, Stephanie, Dooley, Kevin, Sathyanarayanan, Sriram, Finn, Jonathan

Volltext

Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context von Severyn, Bryan, Nguyen, Thi, Altman, Michael D., Li, Lixia, Nagashima, Kumiko, Naumov, George N., Sathyanarayanan, Sriram, Cook, Erica, Morris, Erick, Ferrer, Marc, Arthur, Bill, Benita, Yair, Watters, Jim, Loboda, Andrey, Hermes, Jeff, Gilliland, D. Gary, Cleary, Michelle A., Carroll, Pamela M., Strack, Peter, Tudor, Matt, Andersen, Jannik N.

Volltext

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties von Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.

Volltext

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity von Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, Su Chul, McCoy, Christine, Zhang, Kelvin, Dooley, Kevin, Kasera, Samuel, Zi, Tong, Sisó, Sílvia, Dahlberg, William, Sia, Chang Ling, Patel, Shil, Schmidt, Karl, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram

Volltext

Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12 von Lewis, Nuruddeen D., Sia, Chang Ling, Kirwin, Katherine, Haupt, Sonya, Mahimkar, Gauri, Zi, Tong, Xu, Ke, Dooley, Kevin, Jang, Su Chul, Choi, Bryan, Boutin, Adam, Grube, Andrew, McCoy, Christine, Sanchez-Salazar, Jorge, Doherty, Michael, Gaidukov, Leonid, Estes, Scott, Economides, Kyriakos D., Williams, Douglas E., Sathyanarayanan, Sriram

Volltext

Abstract CT114: Randomized placebo-controlled Phase 1 trial in healthy volunteers investigating safety, PK and PD of exoIL-12 - a novel engineered exosome therapeutic candidate von Mitchell, James, Scarisbrick, Julia, De Francesco, Irene, Cowan, Richard, McKay, Pam, Osborne, Wendy, Sathyanarayanan, Sriram, Ascolillo, Luke, Gow, Irene, Hill, Wendy, Lorch, Ulrike, Sorensen, Benny

Volltext

Interaction Between Sleep and the Immune Response in Drosophila: A Role for the NFκB Relish von Williams, Julie A., Sathyanarayanan, Sriram, Hendricks, Joan C., Sehgal, Amita

Volltext

Abstract 1792: Engineered exosome- mediated STAT6 knockdown in tumor associated macrophages (TAMs) results in potent single agent activity in a hepatocellular carcinoma (HCC) model von Kamerkar, Sushrut, Leng, Charan, Burenkova, Olga, Jang, Su Chul, McCoy, Christine, Zhang, Kelvin, Dahlberg, William, Leblanc, Marie, Quillery, Hugo, Maubant, Sylvie, Duchamp, Olivier, Economides, Kyriakos, Soos, Timothy, Burzyn, Dalia, Sathyanarayanan, Sriram

Volltext

ICOS agonism by JTX-2011 von Hanson, Amanda, Elpek, Kutlu, Duong, Ellen, Shallberg, Lindsey, Fan, Martin, Johnson, Calvin, Wallace, Matthew, Mabry, George R, Sazinsky, Stephen, Pepper, Lauren, Shu, Chengyi J, Sathyanarayanan, Sriram, Zuerndorfer, Sarah, Simpson, Tyler, Gostissa, Monica, Briskin, Michael, Law, Deborah, Michaelson, Jennifer, Harvey, Christopher J

Volltext