A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice von Mupo, A, Celani, L, Dovey, O, Cooper, J L, Grove, C, Rad, R, Sportoletti, P, Falini, B, Bradley, A, Vassiliou, G S

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Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications von Sportoletti, P, Varasano, E, Rossi, R, Mupo, A, Tiacci, E, Vassiliou, G, Martelli, M P, Falini, B

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The NOTCH1/CD39 axis: a Treg trip-switch for GvHD von Del Papa, B, Pierini, A, Sportoletti, P, Baldoni, S, Cecchini, D, Rosati, E, Dorillo, E, Aureli, P, Zei, T, Iacucci Ostini, R, Ruggeri, L, Carotti, A, Velardi, A, Negrin, R, Martelli, M F, Falzetti, F, Di Ianni, M

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TRACKING CLONAL HEMATOPOIESIS IN PATIENTS WITH CLASSICAL HODGKIN'S LYMPHOMA von Marra, A., Venanzi, A, Schiavoni, G., Milner, S. G., Limongello, R., Santi, A., Pettirossi, V., Ultimo, S., Tasselli, L., Pucciarini, A., Falini, L., Sciabolacci, S., Martelli, M. P., Sportoletti, P., Ascani, S., Falini, B., Tiacci, E.

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A revised NOTCH1 mutation frequency still impacts survival while the allele burden predicts early progression in chronic lymphocytic leukemia von Sportoletti, P, Baldoni, S, Del Papa, B, Aureli, P, Dorillo, E, Ruggeri, L, Plebani, S, Amico, V, Di Tommaso, A, Rosati, E, Marconi, P, Di Ianni, M, Falzetti, F

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Constitutive phosphorylation of the active Notch1 intracellular domain in chronic lymphocytic leukemia cells with NOTCH1 mutation von De Falco, F, Sabatini, R, Falzetti, F, Di Ianni, M, Sportoletti, P, Baldoni, S, Del Papa, B, Screpanti, I, Marconi, P, Rosati, E

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The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence von Cheng, K, Grisendi, S, Clohessy, J G, Majid, S, Bernardi, R, Sportoletti, P, Pandolfi, P P

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The glucocorticoid‐induced TNF receptor family‐related protein (GITR) is critical to the development of acute pancreatitis in mice von Galuppo, M, Nocentini, G, Mazzon, E, Ronchetti, S, Esposito, E, Riccardi, L, Sportoletti, P, Di Paola, R, Bruscoli, S, Riccardi, C, Cuzzocrea, S

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Choice of Frontline Tyrosine‐Kinase Inhibitor and Early Events in Very Elderly Patients With Chronic Myeloid Leukemia in Chronic Phase: A “Campus CML” Study von Bucelli, C., Capodanno, I., Miggiano, M. C., Cavazzini, F., Crescenzi, S. Leonetti, Russo, S., Carmosino, I., Annunziata, M., Sorà, F., Bonifacio, M., Luciano, L., Caocci, G., Loglisci, G., Elena, C., Lunghi, F., Mullai, R., Attolico, I., Binotto, G., Crisà, E., Sportoletti, P., Di Veroli, A., Scortechini, A. R., Leporace, A. P., Maggi, A., Crugnola, M., Stagno, F., Sancetta, R., Murgano, P., Rapezzi, D., Luzi, D., Vincelli, D. I., Galimberti, S., Bocchia, M., Fava, C., Malato, A., Abruzzese, E., Saglio, G., Specchia, G., Breccia, M., Iurlo, A., Tiribelli, M., Latagliata, R.

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FLT3-targeted therapy restores GATA1 pathway function in NPM1/FLT3-ITD mutated acute myeloid leukaemia von Sorcini, D, Stella, A, Scialdone, A, Sartori, S, Marra, A, Rossi, R, De Falco, F, Adamo, F M, Dorillo, E, Geraci, C, Arcaleni, R, Rompietti, C, Esposito, A, Moretti, L, Mameli, M G, Martelli, M P, Falini, B, Sportoletti, P

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EFFICACY AND DISCONTINUATION RATE OF IBRUTINIB IN TREATMENT NAIVE CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS WITH TP53 ABNORMALITIES. A REAL‐LIFE CAMPUS CLL STUDY von Visentin, A., Mauro, F. R., Cibien, F., Vitale, C., Reda, G., Fresa, A., Ciolli, S., Pietrasanta, D., Marchetti, M., Murru, R., Gentile, M., Rigolin, G. M., Quaglia, F. M., Scarfò, L., Sportoletti, P., Pravato, S., Romano Gargarella, L., Facco, M., Piazza, F., Coscia, M., Laurenti, L., Molica, S., Pizzolo, G., Foà, R., Cuneo, A., Trentim, L.

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P664: GRADING QUALITY OF EVIDENCE AND STRENGTH OF RECOMMENDATIONS FOR THE TREATMENT OF RELAPSED/REFRACTORY CLL von Molica, S., Patti, C., Sportoletti, P., Chiarenza, A., Giordano, A. M., Chiurazzi, F., Di Renzo, N., Musto, P., Pane, F., Di Raimondo, F., Trentin, L., Mauro, F. R., Giannarelli, D.

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Treatment-Free Remission (TFR) after Two Different Durations of Nilotinib Consolidation in Patients with Chronic Myeloid Leukemia (CML) Previously Treated with Imatinib: Enestpath... von Rea, Delphine, Kyrcz-Krzemien, Slawomira, Sportoletti, Paolo, Mayer, Jiří, Illes, Arpad, Angona, Anna, Kiani, Alexander, Charbonnier, Aude, Marinakis, Theodoros, Stenke, Leif, Weltermann, Ansgar, Shah, Seema, Supekar, Sharon, Di Caprio, Luigi, Baccarani, Michele

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P458: TRANSCRIPTIONAL AND TRANSLATIONAL SIGNATURES OF TRIPLE MUTATED DNMT3AKO/FLT3ITD/NPM1C MICE SHOW ALTERED RNAS PROCESSING AND CELL CYCLE PROGRESSION von Scialdone, A., Sorcini, D., Stella, A., Tini, V., Marra, A., Rompietti, C., De Falco, F., Dorillo, E., Adamo, F. M., Barcelos, E. C., Arcaleni, R., Martelli, M. P., Sportoletti°, P., Falini°, ° co‐last author, B.

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P712: ASCIMINIB ITALIAN MANAGED ACCESS PROGRAM: EFFICACY PROFILE IN HEAVILY PRE‐TREATED CML PATIENTS von Breccia, M., Russo Rossi, A. V., Martino, B., Abruzzese, E., Annunziata, M., Binotto, G., Ermacora, A., Fava, C., Giaccone, L., Giai, V., Nardozza, A. P., Coco, P., Gozzini, A., Levato, L., Lucchesi, A., Luciano, L., Maria Cristina, M., Rege‐Cambrin, G., Santoro, M., Scappini, B., Scortechini, A. R., Sportoletti, P., Trabacchi, E., Castagnetti, F.

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S139: BCOR DELETION SUSTAINS NOTCH1 SIGNALLING ACTIVATION TO ACCELERATE CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PROGRESSION TOWARD RICHTER TRANSFORMATION IN MICE von Rompietti, C., Sorcini, D., De Falco, F., Dorillo, E., Adamo, F. M., Silva Barcelos, E. C., Stella, A., Scialdone, A., Esposito, A., Arcaleni, R., Bigerna, B., Martino, G., Moretti, L., Mameli, M. G., Geraci, C., Sandoletti, L., Cipiciani, A., Rosati, E., Falini, B., Sportoletti, P.

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P660: SEROLOGIC RESPONSE TO THE SECOND AND THIRD DOSE OF THE SARS‐COV‐2 VACCINE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: RESULTS OF A PROSPECTIVE, CENTRALIZED, MULTICENTER ST... von Mauro, F. R., Giannarelli, D., Galluzzo, C., Visentin, A., Frustaci, A. M., Sportoletti, P., Vitale, C., Reda, G., Gentile, M., Levato, L., Murru, R., Armiento, D., Ielo, C., Maglione, R., Crisanti, E., Cipiciani, A., Mattiello, V., Gianfelici, V., Barabino, L., Amici, R., Coscia, M., Tedeschi, A., Trentin, L., Baroncelli, S.

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Recurrent primary plasmacytoma of the eyelid with rapid regional metastasis von Ria, R., Di Ianni, M., Sportoletti, P., Cimminiello, M., Marcomigni, L., Tabilio, A.

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A Correction to the Research Article Titled: "Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation" by L. Poliseno, L. Salmena, L. Riccardi, A. Fornari, M. S. Song, R. M. Hobbs, P. Sportoletti, S. Varmeh, A. Egia, G. Fedele, L. Rameh, M. Loda, P. P. Pandolfi

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Notch1 modulates MSC-mediated regulatory T cell induction von Di Ianni, M, Del Papa, B, Sportoletti, P, Baldoni, S, Cecchini, D, Falzetti, F

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