S.14.02 EU-AIMS: A trans-dimensional approach for enhancing our understanding of autism spectrum disorders von Spooren, W

Volltext

Translational approaches to the biology of Autism: false dawn or a new era? von Ecker, C, Spooren, W, Murphy, D G M

Volltext

Developing new pharmacotherapies for autism von Ecker, C., Spooren, W., Murphy, D.

Volltext

Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder von Kabitzke, P.A., Brunner, D., He, D., Fazio, P.A., Cox, K., Sutphen, J., Thiede, L., Sabath, E., Hanania, T., Alexandrov, V., Rasmusson, R., Spooren, W., Ghosh, A., Feliciano, P., Biemans, B., Benedetti, M., Clayton, A.L.

Volltext

The Longitudinal European Autism Study: validating biomarkers by mapping symptoms and cognition on the brain von Buitelaar, J.K, Loth, E, Murphy, D, Spooren, W

Volltext

Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders von Spooren, W, Ballard, T, Gasparini, F, Amalric, M, Mutel, V, Schreiber, R

Volltext

Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine von Veeneman, M. M. J., Boleij, H., Broekhoven, M. H., Snoeren, E. M. S., Guitart Masip, M., Cousijn, J., Spooren, W., Vanderschuren, L. J. M. J.

Volltext

Effects of aripiprazole/OPC-14597 on motor activity, pharmacological models of psychosis, and brain activity in rats von Nordquist, R.E., Risterucci, C., Moreau, J.L., von Kienlin, M., Künnecke, B., Maco, M., Freichel, C., Riemer, C., Spooren, W.

Volltext

Allosteric Modulators for mGlu Receptors von Gasparini, F, Spooren, W

Volltext

Metabotropic glutamate receptor modulation, translational methods, and biomarkers: relationships with anxiety von Nordquist, R. E., Steckler, T., Wettstein, J. G., Mackie, C., Spooren, W.

Volltext

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice von Spooren, Will P.J.M, Gasparini, Fabrizio, van der Putten, Herman, Koller, Manuel, Nakanishi, Shigetada, Kuhn, Rainer

Volltext

Cognitive performance in neurokinin 3 receptor knockout mice von Nordquist, R. E., Delenclos, M., Ballard, T. M., Savignac, H., Pauly-Evers, M., Ozmen, L., Spooren, W.

Volltext

PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders von Saenger, S, Goeldner, C, Frey, J.R, Ozmen, L, Ostrowitzki, S, Spooren, W, Ballard, T.M, Prinssen, E, Borroni, E, Metzger, F

Volltext

Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK1 and NK3 receptors von Malherbe, P, Knoflach, F, Hernandez, MC, Hoffmann, T, Schnider, P, Porter, RH, Wettstein, JG, Ballard, TM, Spooren, W, Steward, L

Volltext

Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK 1 and NK 3 receptors von Malherbe, P, Knoflach, F, Hernandez, MC, Hoffmann, T, Schnider, P, Porter, RH, Wettstein, JG, Ballard, TM, Spooren, W, Steward, L

Volltext

Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function: I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain von Walker, K, Bowes, M, Panesar, M, Davis, A, Gentry, C, Kesingland, A, Gasparini, F, Spooren, W, Stoehr, N, Pagano, A, Flor, P.J, Vranesic, I, Lingenhoehl, K, Johnson, E.C, Varney, M, Urban, L, Kuhn, R

Volltext

329 – Dopamine D3 receptor antagonists in rodent models predictive of antipsychotic activity von Nordquist, R.E, Jaeschke, G, Steward, L, Wettstein, J.G, Spooren, W

Volltext

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression von Lindemann, Lothar, Porter, Richard H, Scharf, Sebastian H, Kuennecke, Basil, Bruns, Andreas, von Kienlin, Markus, Harrison, Anthony C, Paehler, Axel, Funk, Christoph, Gloge, Andreas, Schneider, Manfred, Parrott, Neil J, Polonchuk, Liudmila, Niederhauser, Urs, Morairty, Stephen R, Kilduff, Thomas S, Vieira, Eric, Kolczewski, Sabine, Wichmann, Juergen, Hartung, Thomas, Honer, Michael, Borroni, Edilio, Moreau, Jean-Luc, Prinssen, Eric, Spooren, Will, Wettstein, Joseph G, Jaeschke, Georg

Volltext

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article von Kuhn, R, Pagano, A, Stoehr, N, Vranesic, I, Flor, P J, Lingenhöhl, K, Spooren, W, Gentsch, C, Vassout, A, Pilc, A, Gasparini, F

Volltext

Opinion: NK3 receptor antagonists: the next generation of antipsychotics? von Spooren, Will, Riemer, Claus, Meltzer, Herbert

Volltext