Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant von Spoerke, Jill M., Gendreau, Steven, Walter, Kimberly, Qiu, Jiaheng, Wilson, Timothy R., Savage, Heidi, Aimi, Junko, Derynck, Mika K., Chen, Meng, Chan, Iris T., Amler, Lukas C., Hampton, Garret M., Johnston, Stephen, Krop, Ian, Schmid, Peter, Lackner, Mark R.

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Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA von Clark, Travis A., Chung, Jon H., Kennedy, Mark, Hughes, Jason D., Chennagiri, Niru, Lieber, Daniel S., Fendler, Bernard, Young, Lauren, Zhao, Mandy, Coyne, Michael, Breese, Virginia, Young, Geneva, Donahue, Amy, Pavlick, Dean, Tsiros, Alyssa, Brennan, Timothy, Zhong, Shan, Mughal, Tariq, Bailey, Mark, He, Jie, Roels, Steven, Frampton, Garrett M., Spoerke, Jill M., Gendreau, Steven, Lackner, Mark, Schleifman, Erica, Peters, Eric, Ross, Jeffrey S., Ali, Siraj M., Miller, Vincent A., Gregg, Jeffrey P., Stephens, Philip J., Welsh, Allison, Otto, Geoff A., Lipson, Doron

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Molecular biomarker analyses using circulating tumor cells von Punnoose, Elizabeth A, Atwal, Siminder K, Spoerke, Jill M, Savage, Heidi, Pandita, Ajay, Yeh, Ru-Fang, Pirzkall, Andrea, Fine, Bernard M, Amler, Lukas C, Chen, Daniel S, Lackner, Mark R

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A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer von Schöffski, Patrick, Cresta, Sara, Mayer, Ingrid A, Wildiers, Hans, Damian, Silvia, Gendreau, Steven, Rooney, Isabelle, Morrissey, Kari M, Spoerke, Jill M, Ng, Vivian W, Singel, Stina M, Winer, Eric

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ERK inhibition overcomes acquired resistance to MEK inhibitors von Hatzivassiliou, Georgia, Liu, Bonnie, O'Brien, Carol, Spoerke, Jill M, Hoeflich, Klaus P, Haverty, Peter M, Soriano, Robert, Forrest, William F, Heldens, Sherry, Chen, Huifen, Toy, Karen, Ha, Connie, Zhou, Wei, Song, Kyung, Friedman, Lori S, Amler, Lukas C, Hampton, Garret M, Moffat, John, Belvin, Marcia, Lackner, Mark R

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Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase von Pan, Zhengying, Scheerens, Heleen, Li, Shyr-Jiann, Schultz, Brian E., Sprengeler, Paul A., Burrill, L. Chuck, Mendonca, Rohan V., Sweeney, Michael D., Scott, Keana C. K., Grothaus, Paul G., Jeffery, Douglas A., Spoerke, Jill M., Honigberg, Lee A., Young, Peter R., Dalrymple, Stacie A., Palmer, James T.

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Targeted biomarker profiling of matched primary and metastatic estrogen receptor positive breast cancers von Schleifman, Erica B, Desai, Rupal, Spoerke, Jill M, Xiao, Yuanyuan, Wong, Cheryl, Abbas, Ilma, O'Brien, Carol, Patel, Rajesh, Sumiyoshi, Teiko, Fu, Ling, Tam, Rachel N, Koeppen, Hartmut, Wilson, Timothy R, Raja, Rajiv, Hampton, Garret M, Lackner, Mark R

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First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors von Sarker, Debashis, Ang, Joo Ern, Baird, Richard, Kristeleit, Rebecca, Shah, Krunal, Moreno, Victor, Clarke, Paul A, Raynaud, Florence I, Levy, Gallia, Ware, Joseph A, Mazina, Kathryn, Lin, Ray, Wu, Jenny, Fredrickson, Jill, Spoerke, Jill M, Lackner, Mark R, Yan, Yibing, Friedman, Lori S, Kaye, Stan B, Derynck, Mika K, Workman, Paul, de Bono, Johann S

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Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort von Chen, Xiaoji, Chang, Ching-Wei, Spoerke, Jill M, Yoh, Kathryn E, Kapoor, Vidushi, Baudo, Charles, Aimi, Junko, Yu, Mamie, Liang-Chu, May M Y, Suttmann, Rebecca, Huw, Ling-Yuh, Gendreau, Steven, Cummings, Craig, Lackner, Mark R

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Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors von Dolly, Saoirse O, Wagner, Andrew J, Bendell, Johanna C, Kindler, Hedy L, Krug, Lee M, Seiwert, Tanguy Y, Zauderer, Marjorie G, Lolkema, Martijn P, Apt, Doris, Yeh, Ru-Fang, Fredrickson, Jill O, Spoerke, Jill M, Koeppen, Hartmut, Ware, Joseph A, Lauchle, Jennifer O, Burris, 3rd, Howard A, de Bono, Johann S

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Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Re... von Powles, Thomas, Lackner, Mark R, Oudard, Stéphane, Escudier, Bernard, Ralph, Christy, Brown, Janet E, Hawkins, Robert E, Castellano, Daniel, Rini, Brian I, Staehler, Michael D, Ravaud, Alain, Lin, Wei, O'Keeffe, Bridget, Wang, Yulei, Lu, Shan, Spoerke, Jill M, Huw, Ling-Yuh, Byrtek, Michelle, Zhu, Rui, Ware, Joseph A, Motzer, Robert J

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Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models von SPOERKE, Jill M, O'BRIEN, Carol, FRIEDMAN, Lori S, ROSS, Leanne, HAMPTON, Garret M, AMLER, Lukas C, SHAMES, David S, LACKNER, Mark R, HUW, Ling, KOEPPEN, Hartmut, FRIDLYAND, Jane, BRACHMANN, Rainer K, HAVERTY, Peter M, PANDITA, Ajay, MOHAN, Sankar, SAMPATH, Deepak

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Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β von Nakanishi, Yoshito, Walter, Kimberly, Spoerke, Jill M, O'Brien, Carol, Huw, Ling Y, Hampton, Garret M, Lackner, Mark R

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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway von Wallin, Jeffrey J, Edgar, Kyle A, Guan, Jane, Berry, Megan, Prior, Wei Wei, Lee, Leslie, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Olivero, Alan G, Sutherlin, Daniel P, O'Brien, Carol, Spoerke, Jill M, Patel, Sonal, Lensun, Letitia, Kassees, Robert, Ross, Leanne, Lackner, Mark R, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S

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The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast canc... von Bardia, Aditya, Mayer, Ingrid, Winer, Eric, Linden, Hannah M., Ma, Cynthia X., Parker, Barbara A., Bellet, Meritxell, Arteaga, Carlos L., Cheeti, Sravanthi, Gates, Mary, Chang, Ching-Wei, Fredrickson, Jill, Spoerke, Jill M., Moore, Heather M., Giltnane, Jennifer, Friedman, Lori S., Chow Maneval, Edna, Chan, Iris, Jhaveri, Komal

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A multicenter, single‐arm, open‐label, phase 2 study of apitolisib (GDC‐0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study) von Makker, Vicky, Recio, Fernando O., Ma, Ling, Matulonis, Ursula A., Lauchle, Jennifer O., Parmar, Hema, Gilbert, Houston N., Ware, Joseph A., Zhu, Rui, Lu, Shan, Huw, Ling‐Yuh, Wang, Yulei, Koeppen, Hartmut, Spoerke, Jill M., Lackner, Mark R., Aghajanian, Carol A.

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A Phase I Dose‐Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors von Leong, Stephen, Moss, Rebecca A., Bowles, Daniel W., Ware, Joseph A., Zhou, Jing, Spoerke, Jill M., Lackner, Mark R., Shankar, Geetha, Schutzman, Jennifer L., van der Noll, Ruud, Voest, Emile E., Schellens, Jan H.M.

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Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers von Wilson, Timothy R, Udyavar, Akshata R, Chang, Ching-Wei, Spoerke, Jill M, Aimi, Junko, Savage, Heidi M, Daemen, Anneleen, O'Shaughnessy, Joyce A, Bourgon, Richard, Lackner, Mark R

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EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans von Smardon, A, Spoerke, J M, Stacey, S C, Klein, M E, Mackin, N, Maine, E M

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Development of a robust RNA-based classifier to accurately determine ER, PR, and HER2 status in breast cancer clinical samples von Wilson, Timothy R., Xiao, Yuanyuan, Spoerke, Jill M., Fridlyand, Jane, Koeppen, Hartmut, Fuentes, Eloisa, Huw, Ling Y., Abbas, Ilma, Gower, Arjan, Schleifman, Erica B., Desai, Rupal, Fu, Ling, Sumiyoshi, Teiko, O’Shaughnessy, Joyce A., Hampton, Garret M., Lackner, Mark R.

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