887 PHARMACOKINETICS OF SIMEPREVIR (TMC435) IN VOLUNTEERS WITH MODERATE OR SEVERE HEPATIC IMPAIRMENT von Ouwerkerk-Mahadevan, S, Simion, A, Spittaels, K, Beumont- Mauviel, M

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Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons von Van Dorpe, Jo, Smeijers, Liesbet, Dewachter, Ilse, Nuyens, Dieter, Spittaels, Kurt, Van den Haute, Chris, Mercken, Marc, Moechars, Dieder, Laenen, Isabelle, Kuiperi, Cuno, Bruynseels, Koen, Tesseur, Ina, Loos, Ruth, Vanderstichele, Hugo, Checler, Frédéric, Sciot, Raf, Van Leuven, Fred

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Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice von Tesseur, Ina, Van Dorpe, Jo, Spittaels, Kurt, Van den Haute, Chris, Moechars, Dieder, Van Leuven, Fred

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1159 ABSENCE OF PHOTOSENSITIVITY POTENTIAL OF TMC435 IN HEALTHY VOLUNTEERS von Simion, A, Janssens, L, Peeters, M, Ouwerkerk-Mahadevan, S, Spittaels, K, De Smedt, G, Akuma, S.H, Beumont-Mauviel, M

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472 PHARMACOKINETICS OF TMC435 IN SUBJECTS WITH MODERATE HEPATIC IMPAIRMENT von Sekar, V, Simion, A, Peeters, M, Spittaels, K, Lawitz, E, Marbury, T.C, De Smedt, G

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Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice von Van den Haute, C., Spittaels, K., Van Dorpe, J., Lasrado, R., Vandezande, K., Laenen, I., Geerts, H., Van Leuven, F.

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1076 EVALUATION OF METABOLIC INTERACTIONS FOR TMC435 VIA CYTOCHROME P450 (CYP) ENZYMES IN HEALTHY VOLUNTEERS von Sekar, V, Verloes, R, Meyvisch, P, Spittaels, K, Akuma, S.H, De Smedt, G

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Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice von Spittaels, K, Van den Haute, C, Van Dorpe, J, Terwel, D, Vandezande, K, Lasrado, R, Bruynseels, K, Irizarry, M, Verhoye, M, Van Lint, J, R. Vandenheede, J, Ashton, D, Mercken, M, Loos, R, Hyman, B, Van der Linden, A, Geerts, H, Van Leuven, F

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Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice von Dewachter, I, van Dorpe, J, Spittaels, K, Tesseur, I, Van Den Haute, C, Moechars, D, Van Leuven, F

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Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide von Camacho, Ira Espuny, Serneels, Lutgarde, Spittaels, Kurt, Merchiers, Pascal, Dominguez, Diana, De Strooper, Bart

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Coexpression of GSK-3β Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau von Nuydens, R., Van Den Kieboom, G., Nolten, C., Verhulst, C., Van Osta, P., Spittaels, K., Van den Haute, C., De Feyter, E., Geerts, H., Van Leuven, F.

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Presenilin 1 Mediates the Turnover of Telencephalin in Hippocampal Neurons via an Autophagic Degradative Pathway von Esselens, Cary, Oorschot, Viola, Baert, Veerle, Raemaekers, Tim, Spittaels, Kurt, Serneels, Lutgarde, Zheng, Hui, Saftig, Paul, De Strooper, Bart, Klumperman, Judith, Annaert, Wim

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Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain von Moechars, Dieder, Dewachter, Ilse, Lorent, Kristin, Reversé, Delphine, Baekelandt, Veerle, Naidu, Asha, Tesseur, Ina, Spittaels, Kurt, Haute, Chris Van Den, Checler, Fréderic, Godaux, Emile, Cordell, Barbara, Van Leuven, Fred

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Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein von Spittaels, Kurt, Van den Haute, Chris, Van Dorpe, Jo, Bruynseels, Koen, Vandezande, Kris, Laenen, Isabelle, Geerts, Hugo, Mercken, Marc, Sciot, Raf, Van Lommel, Alfons, Loos, Ruth, Van Leuven, Fred

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Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I... von Dewachter, Ilse, Reverse, Delphine, Caluwaerts, Nathalie, Ris, Laurence, Kuiperi, Cuno, Van den Haute, Chris, Spittaels, Kurt, Umans, Lieve, Serneels, Lutgarde, Thiry, Els, Moechars, Dieder, Mercken, Mark, Godaux, Emile, Van Leuven, Fred

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Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice von Spittaels, Kurt, Van den Haute, Chris, Van Dorpe, Jo, Geerts, Hugo, Mercken, Marc, Bruynseels, Koen, Lasrado, Reena, Vandezande, Kris, Laenen, Isabelle, Boon, Tim, Van Lint, Jo, Vandenheede, Jacky, Moechars, Dieder, Loos, Ruth, Van Leuven, Fred

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Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin von Nyabi, Omar, Bentahir, Mostafa, Horré, Katrien, Herreman, An, Gottardi-Littell, Numa, Van Broeckhoven, Christine, Merchiers, Pascal, Spittaels, Kurt, Annaert, Wim, De Strooper, Bart

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Isolation of NEB-LFamide, a novel myotropic neuropeptide from the grey fleshfly von Janssen, I., Schoofs, L., Spittaels, K., Neven, H., Vanden Broeck, J., Devreese, B., Van Beeumen, J., Shabanowitz, J., Hunt, D.F., De Loof, A.

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Isolation and characterization of Locusta migratoria accessory gland myotropin I (Lom-AG-MT-I) from the brain of the Colorado potato beetle, Leptinotarsa decemlineata von Spittaels, K. (Katholieke Universiteit Leuven, Leuven, Belgium.), Vankeerberghen, A, Schoofs, L, Proost, P, Damme, J. van, Loof, A. de

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The orphan G protein-coupled receptor 3 is a novel modulator of amyloid-beta peptide generation in neurons von Thathiah, Amantha, Spittaels, K, Hoffman, M, Staes, M, Cohen, A, Horré, Katrien, Vanbrabant, Mieke, Coun, Frea, Baekelandt, Veerle, Delacourte, A, Fischer, D, Pollet, D, De Strooper, Bart, Merchiers, P

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