METLIN: A Technology Platform for Identifying Knowns and Unknowns von Guijas, Carlos, Montenegro-Burke, J. Rafael, Domingo-Almenara, Xavier, Palermo, Amelia, Warth, Benedikt, Hermann, Gerrit, Koellensperger, Gunda, Huan, Tao, Uritboonthai, Winnie, Aisporna, Aries E, Wolan, Dennis W, Spilker, Mary E, Benton, H. Paul, Siuzdak, Gary

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Metabolite and Microbiome Interplay in Cancer Immunotherapy von Johnson, Caroline H, Spilker, Mary E, Goetz, Laura, Peterson, Scott N, Siuzdak, Gary

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Metabolomics activity screening for identifying metabolites that modulate phenotype von Guijas, Carlos, Montenegro-Burke, J Rafael, Warth, Benedikt, Spilker, Mary E, Siuzdak, Gary

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A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships von Guerrero, Yadir A., Desai, Diti, Sullivan, Connor, Kindt, Erick, Spilker, Mary E., Maurer, Tristan S., Solomon, Deepak E., Bartlett, Derek W.

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Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities von Bradshaw, Erica L., Spilker, Mary E., Zang, Richard, Bansal, Loveleena, He, Handan, Jones, Rhys D.O., Le, Kha, Penney, Mark, Schuck, Edgar, Topp, Brian, Tsai, Alice, Xu, Christine, Nijsen, Marjoleen J.M.A., Chan, Jason R.

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Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape von Nijsen, Marjoleen J.M.A., Wu, Fan, Bansal, Loveleena, Bradshaw‐Pierce, Erica, Chan, Jason R., Liederer, Bianca M., Mettetal, Jerome T., Schroeder, Patricia, Schuck, Edgar, Tsai, Alice, Xu, Christine, Chimalakonda, Anjaneya, Le, Kha, Penney, Mark, Topp, Brian, Yamada, Akihiro, Spilker, Mary E.

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Biodistribution and Targeting of Anti-5T4 Antibody-Drug Conjugate Using Fluorescence Molecular Tomography von Giddabasappa, Anand, Gupta, Vijay R, Norberg, Rand, Gupta, Parul, Spilker, Mary E, Wentland, Joann, Rago, Brian, Eswaraka, Jeetendra, Leal, Mauricio, Sapra, Puja

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Quantitative systems toxicology modeling in pharmaceutical research and development: An industry‐wide survey and selected case study examples von Beattie, Kylie A., Verma, Meghna, Brennan, Richard J., Clausznitzer, Diana, Damian, Valeriu, Leishman, Derek, Spilker, Mary E., Boras, Britton, Li, Zhenhong, Oziolor, Elias, Rieger, Theodore R., Sher, Anna

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A whole‐body circulatory neutrophil model with application to predicting clinical neutropenia from in vitro studies von Chen, Wenbo, Boras, Britton, Sung, Tae, Hu, Wenyue, Spilker, Mary E., D’Argenio, David Z.

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Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses von Goyens, Petra L L, Spilker, Mary E, Zock, Peter L, Katan, Martijn B, Mensink, Ronald P

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Opioidergic activation in the medial pain system after heat pain von Sprenger, Till, Valet, Michael, Boecker, Henning, Henriksen, Gjermund, Spilker, Mary E., Willoch, Frode, Wagner, Klaus J., Wester, Hans J., Tölle, Thomas R.

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A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies von Liu, Shu-Hui, Gu, Yin, Pascual, Bernadette, Yan, Zhengming, Hallin, Max, Zhang, Cathy, Fan, Conglin, Wang, Wenlian, Lam, Justine, Spilker, Mary E., Yafawi, Rolla, Blasi, Eileen, Simmons, Brett, Huser, Nanni, Ho, Wei-Hsien, Lindquist, Kevin, Tran, Thomas-Toan, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Jimenez, Gretchen, Barman, Ishita, Brown, Colleen, Chin, Sherman Michael, Costa, Maria J., Shelton, David, Smeal, Tod, Fantin, Valeria R., Pernasetti, Flavia

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The Runner's High: Opioidergic Mechanisms in the Human Brain von Boecker, Henning, Sprenger, Till, Spilker, Mary E., Henriksen, Gjermund, Koppenhoefer, Marcus, Wagner, Klaus J., Valet, Michael, Berthele, Achim, Tolle, Thomas R.

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Volumetric imaging of optically cleared and fluorescently labeled animal tissue (VIOLA) for quantifying the 3D biodistribution of nanoparticles at cellular resolution in tumor tiss... von Rakhilin, Nikolai, Yang, Bing, Spilker, Mary E., Manzuk, Lisa K., Montgomery, Mary Katherine, Shin, Eyoung, Prashad, Nadira, Hwang, Jungyeon, Song, Youngho, Loganzo, Frank, Giddabasappa, Anand, Ram, Sripad

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Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195) von Cheng, Hengmiao, Orr, Suvi T M, Bailey, Simon, Brooun, Alexei, Chen, Ping, Deal, Judith G, Deng, Yali L, Edwards, Martin P, Gallego, Gary M, Grodsky, Neil, Huang, Buwen, Jalaie, Mehran, Kaiser, Stephen, Kania, Robert S, Kephart, Susan E, Lafontaine, Jennifer, Ornelas, Martha A, Pairish, Mason, Planken, Simon, Shen, Hong, Sutton, Scott, Zehnder, Luke, Almaden, Chau D, Bagrodia, Shubha, Falk, Matthew D, Gukasyan, Hovhannes J, Ho, Caroline, Kang, Xiaolin, Kosa, Rachel E, Liu, Ling, Spilker, Mary E, Timofeevski, Sergei, Visswanathan, Ravi, Wang, Zhenxiong, Meng, Fanxiu, Ren, Shijian, Shao, Li, Xu, Feng, Kath, John C

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Conversion of α-linolenic acid in humans is influenced by the absolute amounts of α-linolenic acid and linoleic acid in the diet and not by their ratio von Goyens, Petra LL, Spilker, Mary E, Zock, Peter L, Katan, Martijn B, Mensink, Ronald P

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Predicting Chemotherapy-Induced Neutropenia and Granulocyte Colony–Stimulating Factor Response Using Model-Based In Vitro to Clinical Translation von Chen, Wenbo, Boras, Britton, Sung, Tae, Hu, Wenyue, Spilker, Mary E., D’Argenio, David Z.

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Mathematical modeling of receptor occupancy data: A valuable technology for biotherapeutic drug development von Spilker, Mary E., Singh, Pratap, Vicini, Paolo

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Found in Translation: Maximizing the Clinical Relevance of Nonclinical Oncology Studies von Spilker, Mary E, Chen, Xiaoying, Visswanathan, Ravi, Vage, Chandra, Yamazaki, Shinji, Li, Gang, Lucas, Judy, Bradshaw-Pierce, Erica L, Vicini, Paolo

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A Review of Imaging Agent Development von Agdeppa, Eric D., Spilker, Mary E.

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