OR7-5: Safety, tolerability, pharmacokinetics and pharmacodynamics of TV-1106, a new long-acting treatment for growth hormone deficiency von CohenBarack, O, Sakov, A, Rasamoelisolo, M, Bassan, M, Brown, K, Spiegelstein, O

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P.0461 Population pharmacokinetic modeling and simulation to guide dose selection for TV-46000, a new long-acting formulation of risperidone for subcutaneous injection von Perlstein, I., Wagner, A. Merenlender, Lamson, M., Spiegelstein, O., Loupe, P., Gomeni, R., Elgart, A.

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Pharmacokinetics, metabolism and safety of deuterated L‐DOPA (SD‐1077)/carbidopa compared to L‐DOPA/carbidopa following single oral dose administration in healthy subjects von Schneider, Frank, Erisson, Lavi, Beygi, Hooman, Bradbury, Margaret, Cohen‐Barak, Orit, Grachev, Igor D., Guzy, Serge, Loupe, Pippa S., Levi, Micha, McDonald, Mirna, Savola, Juha‐Matti, Papapetropoulos, Spyros, Tracewell, William G., Velinova, Maria, Spiegelstein, Ofer

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P.0463 Phase 1 open-label study assessing the pharmacokinetics and safety of TV-46000, a novel long-acting subcutaneous injectable formulation of risperidone von Wagner, A. Merenlender, Elgart, A., Perlstein, I., Lamson, M., Tiver, R., Kalmanczhelyi, A., Spiegelstein, O., Mackellar, A., Harary, E.

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Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice von Isoherranen, Nina, Yagen, Boris, Spiegelstein, Ofer, Finnell, Richard H, Merriweather, Michelle, Woodhead, Jose H, Wlodarczyk, Bogdan, White, H Steve, Bialer, Meir

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Teratogenicity of valproate conjugates with anticonvulsant activity in mice von Spiegelstein, Ofer, Chatterjie, Nithiananda, Alexander, George, Finnell, Richard H

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Pathobiology and Genetics of Neural Tube Defects von Finnell, Richard H., Gould, Amy, Spiegelstein, Ofer

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Effect of Food on the Pharmacokinetics of Single- and Multiple-Dose Hydrocodone Extended Release in Healthy Subjects von Bond, Mary, Rabinovich-Guilatt, Laura, Selim, Sally, Darwish, Mona, Tracewell, William, Robertson, Philmore, Yang, Ronghua, Malamut, Richard, Colucci, Philippe, Ducharme, Murray P., Spiegelstein, Ofer

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Embryonic development of folate binding protein‐1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation von Spiegelstein, Ofer, Mitchell, Laura E., Merriweather, Michelle Y., Wicker, Ned J., Zhang, Qiang, Lammer, Edward J., Finnell, Richard H.

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P386 Pharmacokinetics of laquinimod in patients with active moderate to severe Crohn's disease von D'Haens, G., Sandborn, W.J., Rutgeerts, P., Colombel, J.F., Mimrod, D., Spiegelstein, O., Brown, K., Feagan, B.

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Identification of two putative novel folate receptor genes in humans and mouse von Spiegelstein, Ofer, Eudy, James D, Finnell, Richard H

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Enantioselective synthesis and teratogenicity of propylisopropyl acetamide, a CNS-active chiral amide analogue of valproic acid von Spiegelstein, Ofer, Bialer, Meir, Radatz, Matthias, Nau, Heinz, Yagen, Boris

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Developmental Outcome of Levetiracetam, Its Major Metabolite in Humans, 2‐Pyrrolidinone N‐Butyric Acid, and Its Enantiomer (R)‐α‐ethyl‐oxo‐pyrrolidine Acetamide in a Mouse Model of... von Isoherranen, Nina, Spiegelstein, Ofer, Bialer, Meir, Zhang, Jing, Merriweather, Michelle, Yagen, Boris, Roeder, Michael, Triplett, Aleata A., Schurig, Volker, Finnell, Richard H.

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Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice von Spiegelstein, Ofer, Lu, Xiufen, Le, X.Chris, Troen, Aron, Selhub, Jacob, Melnyk, Stepan, James, S.Jill, Finnell, Richard H.

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Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos von Spiegelstein, Ofer, Cabrera, Robert M, Bozinov, Daniel, Wlodarczyk, Bogdan, Finnell, Richard H

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Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies von Spiegelstein, Ofer, Gould, Amy, Wlodarczyk, Bogdan, Tsie, Marlene, Lu, Xiufen, Le, Chris, Troen, Aron, Selhub, Jacob, Piedrahita, Jorge A., Salbaum, J. Michael, Kappen, Claudia, Melnyk, Stepan, James, Jill, Finnell, Richard H.

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Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice von Spiegelstein, Ofer, Merriweather, Michelle Y., Wicker, Ned J., Finnell, Richard H.

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Gene-specific monitoring of T7-based RNA amplification by real-time quantitative PCR von Heil, Sandra G, Kluijtmans, Leo A.J, Spiegelstein, Ofer, Finnell, Richard H, Blom, Hank J

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Central nervous system effects of the histamine‐3 receptor antagonist CEP‐26401, in comparison with modafinil and donepezil, after a single dose in a cross‐over study in healthy vo... von Baakman, A.C., Zuiker, R., Gerven, J.M.A. van, Gross, N., Yang, R., Fetell, M., Gershon, A., Gilgun-Sherki, Y., Hellriegel, E., Spiegelstein, O.

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Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid von SPIEGELSTEIN, O, KROETZ, D. L, LEVY, R. H, YAGEN, B, HURST, S. I, LEVI, M, HAJ-YEHIA, A, BIALER, M

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