Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa von Verner, Erik, Katz, Bradley A, Spencer, Jeffrey R, Allen, Darin, Hataye, Jason, Hruzewicz, Witold, Hui, Hon C, Kolesnikov, Aleksandr, Li, Yong, Luong, Christine, Martelli, Arnold, Radika, Kesavan, Rai, Roopa, She, Miles, Shrader, William, Sprengeler, Paul A, Trapp, Sean, Wang, Jing, Young, Wendy B, Mackman, Richard L

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Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in viv... von Miller, James L., Rai, Myriam, Frigon, Normand L., Pandolfo, Massimo, Punnonen, Juha, Spencer, Jeffrey R.

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Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor von Miller, James L, Church, Timothy J, Leonoudakis, Dmitri, Lariosa-Willingham, Karen, Frigon, Normand L, Tettenborn, Connie S, Spencer, Jeffrey R, Punnonen, Juha

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Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo von Spencer, Jeffrey R., Sendzik, Martin, Oeh, Jason, Sabbatini, Peter, Dalrymple, Stacie A., Magill, Catherine, Kim, Hyunjin M., Zhang, Penglie, Squires, Neil, Moss, Katherine G., Sukbuntherng, Juthamas, Graupe, Doris, Eksterowicz, John, Young, Peter R., Myers, Andrew G., Green, Michael J.

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Antitumor activity of tetrahydroisoquinoline analogues 3- epi-jorumycin and 3- epi-renieramycin G von Lane, Jonathan W., Estevez, Alberto, Mortara, Kyle, Callan, Ondine, Spencer, Jeffrey R., Williams, Robert M.

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Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2 H-pyran-3-yl)-7-phenyl-( E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS... von Drewe, John, Kasibhatla, Shailaja, Tseng, Ben, Shelton, Emma, Sperandio, David, Yee, Robert M., Litvak, Joane, Sendzik, Martin, Spencer, Jeffrey R., Cai, Sui Xiong

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Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors von Palmer, James T., Rydzewski, Robert M., Mendonca, Rohan V., Sperandio, David, Spencer, Jeffrey R., Hirschbein, Bernard L., Lohman, Julia, Beltman, Jeri, Nguyen, Margaret, Liu, Liang

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Discovery of novel hydroxy pyrazole based factor IXa inhibitor von Vijaykumar, Dange, Sprengeler, Paul A., Shaghafi, Michael, Spencer, Jeffrey R., Katz, Brad A., Yu, Christine, Rai, Roopa, Young, Wendy B., Schultz, Brian, Janc, James

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Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors von Katz, Bradley A., Elrod, Kyle, Verner, Erik, Mackman, Richard L., Luong, Christine, Shrader, William D., Sendzik, Martin, Spencer, Jeffrey R., Sprengeler, Paul A., Kolesnikov, Aleks, Tai, Vincent W.-F., Hui, Hon C., Guy Breitenbucher, J., Allen, Darin, Janc, James W.

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Discovery and structure–activity relationship of 2-phenyl-oxazole-4-carboxamide derivatives as potent apoptosis inducers von Tai, Vincent W.-F., Sperandio, David, Shelton, Emma J., Litvak, Joane, Pararajasingham, Keith, Cebon, Ben, Lohman, Julia, Eksterowicz, John, Kantak, Seema, Sabbatini, Peter, Brown, Cindy, Zeitz, Jennifer, Reed, Chris, Maske, Bill, Graupe, Doris, Estevez, Alberto, Oeh, Jason, Wong, Darren, Ni, Yong, Sprengeler, Paul, Yee, Robert, Magill, Catherine, Neri, Anthony, Cai, Sui Xiong, Drewe, John, Qiu, Ling, Herich, John, Tseng, Ben, Kasibhatla, Shailaja, Spencer, Jeffrey R.

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Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles von Lee, Chang-Sun, Liu, Weili, Sprengeler, Paul A., Somoza, John R., Janc, James W., Sperandio, David, Spencer, Jeffrey R., Green, Michael J., McGrath, Mary E.

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Novel, potent, selective, and orally bioavailable human βII-tryptase inhibitors von Sperandio, David, Tai, Vincent W.-F., Lohman, Julia, Hirschbein, Bernie, Mendonca, Rohan, Lee, Chang-Sun, Spencer, Jeffrey R., Janc, James, Nguyen, Margaret, Beltman, Jerlyn, Sprengeler, Paul, Scheerens, Heleen, Lin, Tong, Liu, Liang, Gadre, Ashwini, Kellogg, Alisha, Green, Michael J., McGrath, Mary E.

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Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease von Sperandio, David, Gangloff, Anthony R., Litvak, Joane, Goldsmith, Richard, Hataye, Jason M., Wang, Vivian R., Shelton, Emma J., Elrod, Kyle, Janc, James W., Clark, James M., Rice, Ken, Weinheimer, Steve, Yeung, Kap-Sun, Meanwell, Nicholas A., Hernandez, Dennis, Staab, Andrew J., Venables, Brian L., Spencer, Jeffrey R.

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Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors von Katz, Bradley A, Spencer, Jeffrey R, Elrod, Kyle, Luong, Christine, Mackman, Richard L, Rice, Mark, Sprengeler, Paul A, Allen, Darin, Janc, James

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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors von MACKMAN, Richard L, HUI, Hon C, SPRENGELER, Paul A, TARIO, James, VERNER, Erik, JING WANG, BREITENBUCHER, J. Guy, KATZ, Bradley A, LUONG, Christine, MARTELLI, Arnold, MCGEE, Danny, RADIKA, Kesavan, SENDZIK, Martin, SPENCER, Jeffrey R

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4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors von Spencer, Jeffrey R, McGee, Danny, Allen, Darin, Katz, Bradley A, Luong, Christine, Sendzik, Martin, Squires, Neil, Mackman, Richard L

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Design and Evaluation of Potent Inhibitors of Asparagine-Linked Protein Glycosylation von Hendrickson, Tamara L, Spencer, Jeffrey R, Kato, Mihoko, Imperiali, Barbara

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Structural and Functional Characterization of a Constrained Asx-Turn Motif von Imperiali, Barbara, Spencer, Jeffrey R, Struthers, Mary D

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Differential Effects of a Novel Non-Peptidic Thrombopoietin Mimetic on Proliferation and Differentiation of Human CD34+ Progenitor Cells von Punnonen, Juha, Muench, Marcus O., Spencer, Jeffrey R.

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Unusual peptide bond cleavage reactions during acidolytic deprotection reactions von Spencer, Jeffrey R, Delaet, Nancy G. J, Toy-Palmer, Anna, Antonenko, Valery V, Goodman, Murray

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