Mutation-specific reporter for optimization and enrichment of prime editing von Schene, I. F., Joore, I. P., Baijens, J. H. L., Stevelink, R., Kok, G., Shehata, S., Ilcken, E. F., Nieuwenhuis, E. C. M., Bolhuis, D. P., van Rees, R. C. M., Spelier, S. A., van der Doef, H. P. J., Beekman, J. M., Houwen, R. H. J., Nieuwenhuis, E. E. S., Fuchs, S. A.

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CFTR and colorectal cancer susceptibility: an urgent need for further studies von Spelier, S, Derksen, S, Hofland, R, Beekman, J M, Yetkin-Arik, B

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Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids von de Poel, E., Spelier, S., Suen, S.W.F., Kruisselbrink, E., Graeber, S.Y., Mall, M.A., Weersink, E.J.M., van der Eerden, M.M., Koppelman, G.H., van der Ent, C.K., Beekman, J.M.

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FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes von de Poel, E., Spelier, S., Hagemeijer, M.C., van Mourik, P., Suen, S.W.F., Vonk, A.M., Brunsveld, J.E., Ithakisiou, G.N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K.M., Heida-Michel, S., Jans, S.R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E.J.M., Koppelman, G.H., Blaazer, A.R., Muijlwijk-Koezen, J.E., van der Ent, C.K., Beekman, J.M.

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Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review von de Kort, W. W. B., Spelier, S., Devriese, L. A., van Es, R. J. J., Willems, S. M.

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WS16.06 Development of a high throughput functional screen allows drug repurposing and reveals novel drug candidates for recusing CFTR function in patient-derived organoids with no... von Spelier, S., de Poel, E., Beekman, J.

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239 Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: A personalized approach von Spelier, S., van der Ent, K., Beekman, J., Kamphuis, L.

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686 High-throughput functional assay using patient-derived organoids allows drug repurposing for cystic fibrosis von Spelier, S., de Poel, E., Beekman, J., van der Ent, C.

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209 Submerged differentiation of primary human airway cells facilitates functional studies and super resolution imaging von Ithakisiou, N., Spelier, S., Dreyer, H., Amatngalim, G., Nijenhuis, W., Kapitein, L., Nijhuis, M., Lebbink, R., Beekman, J.

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P285 Towards a better understanding of colorectal adenomas and cancer in cystic fibrosis von Hofland, R., Spelier, S., Bronsveld, I., van der Hout, E., Heijerman, H., van derWindt, I., van Meer, S., Lacle, M., Beekman, J.

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Predictive Value of EGFR-PI3K-AKT-mTOR-Pathway Inhibitor Biomarkers for Head and Neck Squamous Cell Carcinoma: A Systematic Review von de Kort, W. W.B, Spelier, S, Devriese, L. A, van Es, R. J.J, Willems, S. M

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Mutation-specific reporter for optimization and enrichment of prime editing von Schene, I F, Joore, I P, Baijens, J H L, Stevelink, R, Kok, G, Shehata, S, Ilcken, E F, Nieuwenhuis, E E S, Bolhuis, D P, van Rees, R C M, Spelier, S A, van der Doef, H P J, Beekman, J M, Houwen, R H J, Fuchs, S A

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Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids von de Poel, E, Spelier, S, Suen, S. W.F, Kruisselbrink, E, Graeber, S. Y, Mall, M. A, Weersink, E. J.M, van der Eerden, M. M, Koppelman, G. H, van der Ent, C. K, Beekman, J. M

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P100 Undergraduate research-based education for identifying new treatment options for cystic fibrosis von Scheen, N., Bains, J., Bonapart, J.-A., Braak, V. ter, Clevers, K., Covers, S., Duin, L., Haaksman, A., Holla, D., Huizer, J., Jong, A. de, Koopman, M., Krebbeks, L., Smits, E., Verburg, M., Willaarts, T., Spelier, S., Lefferts, J., ten Broeke, T., Crnko, S., Pijnappel, E., Meeldijk, J., Perzolli, A., Tielkens, A., Muilwijk, D., Amatngalim, G., Thies-Weesie, D., Veenendaal, T., van der Ent, C.K., Beekman, J., Bovenschen, N.

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P01.05 Modelling T Cell migration in 3D vascular beds in a high-throughput microfluidic platform von Spelier, S, de Haan, L, Suijker, J, Walinga, E, van den Broek, L, Lanz, H, Joore, J, Vulto, P, Queiroz, K

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Readthrough compounds for nonsense mutations: bridging the translational gap von Spelier, Sacha, van Doorn, Eveline P.M., van der Ent, Cornelis K., Beekman, Jeffrey M., Koppens, Martijn A.J.

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Counting curves and their rational points von Spelier, P.

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Geometric quadratic Chabauty and p-adic heights von Duque-Rosero, Juanita, Hashimoto, Sachi, Spelier, Pim

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Readthrough compounds for nonsense mutations: bridging the translational gap von Spelier, Sacha, van Doorn, Eveline P.M, van der Ent, Cornelis K, Beekman, Jeffrey M, Koppens, Martijn A.J

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Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy von Driehuis, Else, Kolders, Sigrid, Spelier, Sacha, Lõhmussaar, Kadi, Willems, Stefan M, Devriese, Lot A, de Bree, Remco, de Ruiter, Emma J, Korving, Jeroen, Begthel, Harry, van Es, Johan H, Geurts, Veerle, He, Gui-Wei, van Jaarsveld, Richard H, Oka, Rurika, Muraro, Mauro J, Vivié, Judith, Zandvliet, Maurice M J M, Hendrickx, Antoni P A, Iakobachvili, Nino, Sridevi, Priya, Kranenburg, Onno, van Boxtel, Ruben, Kops, Geert J P L, Tuveson, David A, Peters, Peter J, van Oudenaarden, Alexander, Clevers, Hans

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