Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer von SPECTOR, Neil L, BLACKWELL, Kimberly L

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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models von Xia, Wenle, Petricoin, 3rd, Emanual F, Zhao, Sumin, Liu, Leihua, Osada, Takuya, Cheng, Qing, Wulfkuhle, Julia D, Gwin, William R, Yang, Xiaoyi, Gallagher, Rosa I, Bacus, Sarah, Lyerly, H Kim, Spector, Neil L

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A Model of Acquired Autoresistance to a Potent ErbB2 Tyrosine Kinase Inhibitor and a Therapeutic Strategy to Prevent Its Onset in Breast Cancer von Xia, Wenle, Bacus, Sarah, Hegde, Priti, Husain, Intisar, Strum, Jay, Liu, Leihua, Paulazzo, Georgina, Lyass, Ljuba, Trusk, Patricia, Hill, Jason, Harris, Jennifer, Spector, Neil L.

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Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors von CHEN, Franklin L, WENLE XIA, SPECTOR, Neil L

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Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program von Vashistha, Vishal, Poonnen, Pradeep J, Snowdon, Jane L, Skinner, Halcyon G, McCaffrey, Victoria, Spector, Neil L, Hintze, Bradley, Duffy, Jill E, Weeraratne, Dilhan, Jackson, Gretchen P, Kelley, Michael J, Patel, Vimla L

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Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily... von Burris, 3rd, Howard A, Hurwitz, Herbert I, Dees, E Claire, Dowlati, Afshin, Blackwell, Kimberly L, O'Neil, Bert, Marcom, Paul K, Ellis, Matthew J, Overmoyer, Beth, Jones, Suzanne F, Harris, Jennifer L, Smith, Deborah A, Koch, Kevin M, Stead, Andrew, Mangum, Steve, Spector, Neil L

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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis von Xia, Wenle, Gooden, David, Liu, Leihua, Zhao, Sumin, Soderblom, Erik J, Toone, Eric J, Beyer, Jr, Wayne F, Walder, Harold, Spector, Neil L

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Phase II Study of Predictive Biomarker Profiles for Response Targeting Human Epidermal Growth Factor Receptor 2 (HER-2) in Advanced Inflammatory Breast Cancer With Lapatinib Monoth... von JOHNSTON, Stephen, TRUDEAU, Maureen, HARRIS, Jennifer, WESTLUND, Ron E, SALAZAR, Vanessa, ZAKS, Tal Z, SPECTOR, Neil L, KAUFMAN, Bella, BOUSSEN, Hamouda, BLACKWELL, Kimberley, LORUSSO, Patricia, LOMBARDI, Donald P, AHMED, Slim Ben, CITRIN, Dennis L, DESILVIO, Michelle L

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways von Xia, Wenle, Mullin, Robert J, Keith, Barry R, Liu, Lei-Hua, Ma, Hong, Rusnak, David W, Owens, Gary, Alligood, Krystal J, Spector, Neil L

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X-Ray Psoralen Activated Cancer Therapy (X-PACT) von Oldham, Mark, Yoon, Paul, Fathi, Zak, Beyer, Wayne F, Adamson, Justus, Liu, Leihua, Alcorta, David, Xia, Wenle, Osada, Takuya, Liu, Congxiao, Yang, Xiao Y, Dodd, Rebecca D, Herndon, 2nd, James E, Meng, Boyu, Kirsch, David G, Lyerly, H Kim, Dewhirst, Mark W, Fecci, Peter, Walder, Harold, Spector, Neil L

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Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor von Spector, Neil L, Robertson, Faith C, Bacus, Sarah, Blackwell, Kimberly, Smith, Deborah A, Glenn, Kelli, Cartee, Leanne, Harris, Jennifer, Kimbrough, Carie L, Gittelman, Mark, Avisar, Eli, Beitsch, Peter, Koch, Kevin M

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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies von Spector, Neil L, Xia, Wenle, Burris, 3rd, Howard, Hurwitz, Herbert, Dees, E Claire, Dowlati, Afshin, O'Neil, Bert, Overmoyer, Beth, Marcom, Paul K, Blackwell, Kimberly L, Smith, Deborah A, Koch, Kevin M, Stead, Andrew, Mangum, Steven, Ellis, Matthew J, Liu, Leihua, Man, Albert K, Bremer, Troy M, Harris, Jennifer, Bacus, Sarah

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 von Kurokawa, Manabu, Kim, Jiyeon, Geradts, Joseph, Matsuura, Kenkyo, Liu, Liu, Ran, Xu, Xia, Wenle, Ribar, Thomas J, Henao, Ricardo, Dewhirst, Mark W, Kim, Wun-Jae, Lucas, Joseph E, Wang, Shaomeng, Spector, Neil L, Kornbluth, Sally

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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells von Spector, Neil L, Yarden, Yosef, Smith, Bradley, Lyass, Ljuba, Trusk, Patricia, Pry, Karen, Hill, Jason E, Xia, Wenle, Seger, Rony, Bacus, Sarah S

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Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers von WENLE XIA, BISI, John, WESTLUND, Ron E, SUMIN ZHAO, BACUS, Sarah, SPECTOR, Neil L, STRUM, Jay, LEIHUA LIU, CARRICK, Kevin, GRAHAM, Katherine M, TREECE, Amanda L, HARDWICKE, Mary Ann, DUSH, Michael, QIAOYIN LIAO

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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer von Cheng, Qing, Chang, Jeffrey T, Geradts, Joseph, Neckers, Leonard M, Haystead, Timothy, Spector, Neil L, Lyerly, H Kim

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Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA von Xia, Wenle, Bacus, Sarah, Husain, Intisar, Liu, Leihua, Zhao, Sumin, Liu, Zuguo, Moseley, 3rd, M Arthur, Thompson, J Will, Chen, Franklin L, Koch, Kevin M, Spector, Neil L

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Visualizing Borrelia burgdorferi Infection Using a Small-Molecule Imaging Probe von Sell, Madeline G, Alcorta, David A, Padilla, Andrew E, Nollner, Dakota W, Hasenkampf, Nicole R, Lambert, Havard S, Embers, Monica E, Spector, Neil L

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Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells von Kam, Angel Y F, Piryani, Sadhna O, Lee, Chang-Lung, Rizzieri, David A, Spector, Neil L, Sarantopoulos, Stefanie, Doan, Phuong L

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Pertuzumab protects the achilles' heel of trastuzumab--emtansine von Gwin, William R, Spector, Neil L

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