Discovery and Development of α7 Nicotinic Acetylcholine Receptor Modulators von Mazurov, Anatoly A, Speake, Jason D, Yohannes, Daniel

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3D Molecular Descriptors Important for Clinical Success von Kombo, David C, Tallapragada, Kartik, Jain, Rachit, Chewning, Joseph, Mazurov, Anatoly A, Speake, Jason D, Hauser, Terry A, Toler, Steve

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Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats von Loram, Lisa C, Taylor, Frederick R, Strand, Keith A, Maier, Steven F, Speake, Jason D, Jordan, Kristen G, James, John W, Wene, Steven P, Pritchard, Robert C, Green, Heather, Van Dyke, Katherine, Mazarov, Anatoly, Letchworth, Sharon R, Watkins, Linda R

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Discovery of 3‑(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cog... von Mazurov, Anatoly A, Miao, Lan, Bhatti, Balwinder S, Strachan, Jon-Paul, Akireddy, Srinivasa, Murthy, Srinivasa, Kombo, David, Xiao, Yun-de, Hammond, Philip, Zhang, Jenny, Hauser, Terry A, Jordan, Kristen G, Miller, Craig H, Speake, Jason D, Gatto, Gregory J, Yohannes, Daniel

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Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: Correlation with desensitization of α4β2 receptors von Zhang, Jiahui, Xiao, Yun-De, Jordan, Kristen G., Hammond, Phil S., Van Dyke, Katherine M., Mazurov, Anatoly A., Speake, Jason D., Lippiello, Patrick M., James, John W., Letchworth, Sharon R., Bencherif, Merouane, Hauser, Terry A.

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Tetrahydroquinoline derivatives as opioid receptor antagonists von Zhang, Cunyu, Westaway, Susan M., Speake, Jason D., Bishop, Michael J., Goetz, Aaron S., Carballo, Luz Helena, Hu, Mike, Epperly, Andrea H.

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Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists von YUPING GONG, ZHIYANG ZHAO, MCCONN, Donavon J, BEAUDET, Beth, TALLMAN, Melanie, SPEAKE, Jason D, IGNAR, Diane M, KRISE, Jeffrey P

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DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis von Mowbray, Charles E, Braillard, Stéphanie, Glossop, Paul A, Whitlock, Gavin A, Jacobs, Robert T, Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J, Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H, Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan

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Novel benzimidazole-based MCH R1 antagonists von Carpenter, Andrew J., Al-Barazanji, Kamal A., Barvian, Kevin K., Bishop, Michael J., Britt, Christy S., Cooper, Joel P., Goetz, Aaron S., Grizzle, Mary K., Hertzog, Donald L., Ignar, Diane M., Morgan, Ronda O., Peckham, Gregory E., Speake, Jason D., Swain, Will R.

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DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis von Mowbray, Charles E, Braillard, Stéphanie, Glossop, Paul A, Whitlock, Gavin A, Jacobs, Robert T, Speake, Jason, Pandi, Bharathi, Nare, Bakela, Maes, Louis, Yardley, Vanessa, Freund, Yvonne, Wall, Richard J, Carvalho, Sandra, Bello, Davide, Van den Kerkhof, Magali, Caljon, Guy, Gilbert, Ian H, Corpas-Lopez, Victoriano, Lukac, Iva, Patterson, Stephen, Zuccotto, Fabio, Wyllie, Susan

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Recent advances in the development of melanocortin-4 receptor agonists von Speake, Jason D, Bishop, Michael J

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α1-Adrenoceptor agonists: The identification of novel α1A Subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines von BISHOP, Michael J, BARVIAN, Kevin A, SAUSSY, David L, SPEAKE, Jason D, BERMAN, Judd, BIGHAM, Eric C, GARRISON, Deanna T, GOBEL, Michael J, HODSON, Stephen J, IRVING, Paul E, LIACOS, James A, NAVAS, Frank III

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Synthetic Studies on Quassinoids:  Total Synthesis and Biological Evaluation of (+)-Des-d-chaparrinone von Grieco, Paul A, Speake, Jason D

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2-(anilinomethyl)imidazolines as α1 adrenergic receptor agonists : α1a subtype selective 2'-heteroaryl compounds von SPEAKE, Jason D, NAVAS, Frank III, BISHOP, Michael J, GARRISON, Deanna T, BIGHAM, Eric C, HODSON, Stephen J, SAUSSY, David L, LIACOS, Jim A, IRVING, Paul E, SHERMAN, Bryan W

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Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel μ-Opioid Receptor-Selective Inverse Agonist von Ignar, Diane M., Goetz, Aaron S., Noble, Kimberly Nichols, Carballo, Luz Helena, Stroup, Andrea E., Fisher, Julie C., Boucheron, Joyce A., Brainard, Tracy A., Larkin, Andrew L., Epperly, Andrea H., Shearer, Todd W., Sorensen, Scott D., Speake, Jason D., Hommel, Jonathan D.

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2-(Anilinomethyl)imidazolines as α1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series von NAVAS, Frank III, BISHOP, Michael J, GOBEL, M. Jeffrey, GARRISON, Deanna T, HODSON, Stephen J, SPEAKE, Jason D, BIGHAM, Eric C, DREWRY, David H, SAUSSY, David L, LIACOS, James H, IRVING, Paul E

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Identification and pharmacological characterization of 3,6-diazabicyclo[3.1.1]heptane-3-carboxamides as novel ligands for the α4β2 and α6/α3β2β3 nicotinic acetylcholine receptors (... von Strachan, Jon-Paul, Kombo, David C., Mazurov, Anatoly, Heemstra, Ronald, Bhatti, Balwinder S., Akireddy, Rao, Murthy, Srinivasa, Miao, Lan, Jett, John E., Speake, Jason, Bencherif, Merouane

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α1-Adrenoceptor activation: A comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines von HODSON, Stephen J, BIGHAM, Eric C, BISHOP, Michael J, GARRISON, Deanna T, GOBEL, Michael J, IRVING, Paul E, LIACOS, James A, NAVAS, Frank III, SAUSSY, David L, SHERMAN, Bryan W, SPEAKE, Jason D

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Studies directed toward the total synthesis of scytophycin C: Synthesis of the C(1)C(18) fragment of scytophycin C von Grieco, Paul A., Speake, Jason D.

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Discovery of novel alpha 7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs von Kombo, David C, Mazurov, Anatoly A, Chewning, Joseph, Hammond, Philip S, Tallapragada, Kartik, Hauser, Terry A, Speake, Jason, Yohannes, Daniel, Caldwell, William S

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