Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway von Sanchez, Jacint G., Chiang, Jessica J., Sparrer, Konstantin M.J., Alam, Steven L., Chi, Michael, Roganowicz, Marcin D., Sankaran, Banumathi, Gack, Michaela U., Pornillos, Owen

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TRIM Proteins and Their Roles in Antiviral Host Defenses von van Gent, Michiel, Sparrer, Konstantin M.J, Gack, Michaela U

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Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2 von Pastorio, Chiara, Zech, Fabian, Noettger, Sabrina, Jung, Christoph, Jacob, Timo, Sanderson, Theo, Sparrer, Konstantin M.J., Kirchhoff, Frank

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In vivo ligands of MDA5 and RIG-I in measles virus-infected cells von Runge, Simon, Sparrer, Konstantin M J, Lässig, Charlotte, Hembach, Katharina, Baum, Alina, García-Sastre, Adolfo, Söding, Johannes, Conzelmann, Karl-Klaus, Hopfner, Karl-Peter

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TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense von Sanchez, Jacint G., Sparrer, Konstantin M.J., Chiang, Cindy, Reis, Rebecca A., Chiang, Jessica J., Zurenski, Matthew A., Wan, Yueping, Gack, Michaela U., Pornillos, Owen

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Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins von Braun, Elisabeth, Hotter, Dominik, Koepke, Lennart, Zech, Fabian, Groß, Rüdiger, Sparrer, Konstantin M.J., Müller, Janis A., Pfaller, Christian K., Heusinger, Elena, Wombacher, Rebecka, Sutter, Kathrin, Dittmer, Ulf, Winkler, Michael, Simmons, Graham, Jakobsen, Martin R., Conzelmann, Karl-Klaus, Pöhlmann, Stefan, Münch, Jan, Fackler, Oliver T., Kirchhoff, Frank, Sauter, Daniel

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Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+T cells von Bosso, Matteo, Bozzo, Caterina Prelli, Hotter, Dominik, Volcic, Meta, Stuerzel, Christina M., Rammelt, Annika, Ni, Yi, Urban, Stephan, Becker, Miriam, Schelhaas, Mario, Wittmann, Sabine, Christensen, Maria H., Schmidt, Florian, Gramberg, Thomas, Sparrer, Konstantin M. J., Sauter, Daniel, Kirchhoff, Frank

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Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids von Krüger, Jana, Groß, Rüdiger, Conzelmann, Carina, Müller, Janis A., Koepke, Lennart, Sparrer, Konstantin M.J., Weil, Tatjana, Schütz, Desiree, Seufferlein, Thomas, Barth, Thomas F.E., Stenger, Steffen, Heller, Sandra, Münch, Jan, Kleger, Alexander

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Regulation of STING activity in DNA sensing by ISG15 modification von Lin, Chaohui, Kuffour, Edmund Osei, Fuchs, Nina V., Gertzen, Christoph G.W., Kaiser, Jesko, Hirschenberger, Maximilian, Tang, Xiao, Xu, Haifeng C., Michel, Oliver, Tao, Ronny, Haase, Alexandra, Martin, Ulrich, Kurz, Thomas, Drexler, Ingo, Görg, Boris, Lang, Philipp A., Luedde, Tom, Sparrer, Konstantin M.J., Gohlke, Holger, König, Renate, Münk, Carsten

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An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins von Bosso, Matteo, Stürzel, Christina M., Kmiec, Dorota, Badarinarayan, Smitha Srinivasachar, Braun, Elisabeth, Ito, Jumpei, Sato, Kei, Hahn, Beatrice H., Sparrer, Konstantin M.J., Sauter, Daniel, Kirchhoff, Frank

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Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2 von Xie, Qinya, Bozzo, Caterina Prelli, Eiben, Laura, Noettger, Sabrina, Kmiec, Dorota, Nchioua, Rayhane, Niemeyer, Daniela, Volcic, Meta, Lee, Jung-Hyun, Zech, Fabian, Sparrer, Konstantin M.J., Drosten, Christian, Kirchhoff, Frank

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Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques von Laliberté, Alexandre, Prelli Bozzo, Caterina, Stahl-Hennig, Christiane, Hunszinger, Victoria, Joas, Simone, Sauermann, Ulrike, Roshani, Berit, Klippert, Antonina, Daskalaki, Maria, Mätz-Rensing, Kerstin, Stolte-Leeb, Nicole, Tharp, Gregory K., Fuchs, Dietmar, Gupta, Prachi Mehrotra, Silvestri, Guido, Nelson, Sydney A., Parodi, Laura, Giavedoni, Luis, Bosinger, Steven E., Sparrer, Konstantin M.J., Kirchhoff, Frank

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Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning? von Jung, Christoph, Kmiec, Dorota, Koepke, Lennart, Zech, Fabian, Jacob, Timo, Sparrer, Konstantin M J, Kirchhoff, Frank

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The antiviral activities of TRIM proteins von Koepke, Lennart, Gack, Michaela U, Sparrer, Konstantin MJ

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Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2 von Thoms, Matthias, Buschauer, Robert, Ameismeier, Michael, Koepke, Lennart, Denk, Timo, Hirschenberger, Maximilian, Kratzat, Hanna, Hayn, Manuel, Mackens-Kiani, Timur, Cheng, Jingdong, Straub, Jan H., Sturzel, Christina M., Frohlich, Thomas, Berninghausen, Otto, Becker, Thomas, Kirchhoff, Frank, Sparrer, Konstantin M. J., Beckmann, Roland

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Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity von Chiang, Jessica J., Sparrer, Konstantin M. J., van Gent, Michiel, Lässig, Charlotte, Huang, Teng, Osterrieder, Nikolaus, Hopfner, Karl-Peter, Gack, Michaela U.

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Head-to-head comparison of different classes of FAP radioligands designed to increase tumor residence time: monomer, dimer, albumin binders, and small molecules vs peptides von Millul, Jacopo, Koepke, Lennart, Haridas, Gaonkar Raghuvir, Sparrer, Konstantin M. J., Mansi, Rosalba, Fani, Melpomeni

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Manipulation of autophagy by SARS-CoV-2 proteins von Koepke, Lennart, Hirschenberger, Maximilian, Hayn, Manuel, Kirchhoff, Frank, Sparrer, Konstantin MJ

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Intracellular detection of viral nucleic acids von Sparrer, Konstantin MJ, Gack, Michaela U

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HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression von Srinivasachar Badarinarayan, Smitha, Shcherbakova, Irina, Langer, Simon, Koepke, Lennart, Preising, Andrea, Hotter, Dominik, Kirchhoff, Frank, Sparrer, Konstantin M J, Schotta, Gunnar, Sauter, Daniel

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