Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities von Gosselin, David, Link, Verena M., Romanoski, Casey E., Fonseca, Gregory J., Eichenfield, Dawn Z., Spann, Nathanael J., Stender, Joshua D., Chun, Hyun B., Garner, Hannah, Geissmann, Frederic, Glass, Christopher K.

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Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription von Kaikkonen, Minna U., Spann, Nathanael J., Heinz, Sven, Romanoski, Casey E., Allison, Karmel A., Stender, Joshua D., Chun, Hyun B., Tough, David F., Prinjha, Rab K., Benner, Christopher, Glass, Christopher K.

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The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response von Blanc, Mathieu, Hsieh, Wei Yuan, Robertson, Kevin A., Kropp, Kai A., Forster, Thorsten, Shui, Guanghou, Lacaze, Paul, Watterson, Steven, Griffiths, Samantha J., Spann, Nathanael J., Meljon, Anna, Talbot, Simon, Krishnan, Kathiresan, Covey, Douglas F., Wenk, Markus R., Craigon, Marie, Ruzsics, Zsolts, Haas, Jürgen, Angulo, Ana, Griffiths, William J., Glass, Christopher K., Wang, Yuqin, Ghazal, Peter

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Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20 von Stender, Joshua D., Pascual, Gabriel, Liu, Wen, Kaikkonen, Minna U., Do, Kevin, Spann, Nathanael J., Boutros, Michael, Perrimon, Norbert, Rosenfeld, Michael G., Glass, Christopher K.

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SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism von Oishi, Yumiko, Spann, Nathanael J., Link, Verena M., Muse, Evan D., Strid, Tobias, Edillor, Chantle, Kolar, Matthew J., Matsuzaka, Takashi, Hayakawa, Sumio, Tao, Jenhan, Kaikkonen, Minna U., Carlin, Aaron F., Lam, Michael T., Manabe, Ichiro, Shimano, Hitoshi, Saghatelian, Alan, Glass, Christopher K.

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Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine von Pirzgalska, Roksana M, Seixas, Elsa, Seidman, Jason S, Link, Verena M, Sánchez, Noelia Martínez, Mahú, Inês, Mendes, Raquel, Gres, Vitka, Kubasova, Nadiya, Morris, Imogen, Arús, Bernardo A, Larabee, Chelsea M, Vasques, Miguel, Tortosa, Francisco, Sousa, Ana L, Anandan, Sathyavathy, Tranfield, Erin, Hahn, Maureen K, Iannacone, Matteo, Spann, Nathanael J, Glass, Christopher K, Domingos, Ana I

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Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis von Seidman, Jason S., Troutman, Ty D., Sakai, Mashito, Gola, Anita, Spann, Nathanael J., Bennett, Hunter, Bruni, Cassi M., Ouyang, Zhengyu, Li, Rick Z., Sun, Xiaoli, Vu, BaoChau T., Pasillas, Martina P., Ego, Kaori M., Gosselin, David, Link, Verena M., Chong, Ling-Wa, Evans, Ronald M., Thompson, Bonne M., McDonald, Jeffrey G., Hosseini, Mojgan, Witztum, Joseph L., Germain, Ronald N., Glass, Christopher K.

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NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids von Li, Pingping, Spann, Nathanael J., Kaikkonen, Minna U., Lu, Min, Oh, Da Young, Fox, Jesse N., Bandyopadhyay, Gautam, Talukdar, Saswata, Xu, Jianfeng, Lagakos, William S., Patsouris, David, Armando, Aaron, Quehenberger, Oswald, Dennis, Edward A., Watkins, Steven M., Auwerx, Johan, Glass, Christopher K., Olefsky, Jerrold M.

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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis von Sun, Xiaoli, Seidman, Jason S., Zhao, Peng, Troutman, Ty D., Spann, Nathanael J., Que, Xuchu, Zhou, Fangli, Liao, Zhongji, Pasillas, Martina, Yang, Xiaohong, Magida, Jason A., Kisseleva, Tatiana, Brenner, David A., Downes, Michael, Evans, Ronald M., Saltiel, Alan R., Tsimikas, Sotirios, Glass, Christopher K., Witztum, Joseph L.

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Mechanisms establishing TLR4-responsive activation states of inflammatory response genes von Escoubet-Lozach, Laure, Benner, Christopher, Kaikkonen, Minna U, Lozach, Jean, Heinz, Sven, Spann, Nathan J, Crotti, Andrea, Stender, Josh, Ghisletti, Serena, Reichart, Donna, Cheng, Christine S, Luna, Rosa, Ludka, Colleen, Sasik, Roman, Garcia-Bassets, Ivan, Hoffmann, Alexander, Subramaniam, Shankar, Hardiman, Gary, Rosenfeld, Michael G, Glass, Christopher K

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Management of Newly Diagnosed Type 2 Diabetes Mellitus (T2DM) in Children and Adolescents von COPELAND, Kenneth C, SILVERSTEIN, Janet, FLINN, Susan K, MOORE, Kelly R, PRAZAR, Greg E, RAYMER, Terry, SHIFFMAN, Richard N, SPRINGER, Shelley C, THAKER, Vidhu V, ANDERSON, Meaghan, SPANN, Stephen J

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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages von Muse, Evan D., Yu, Shan, Edillor, Chantle R., Tao, Jenhan, Spann, Nathanael J., Troutman, Ty D., Seidman, Jason S., Henke, Adam, Roland, Jason T., Ozeki, Katherine A., Thompson, Bonne M., McDonald, Jeffrey G., Bahadorani, John, Tsimikas, Sotirios, Grossman, Tamar R., Tremblay, Matthew S., Glass, Christopher K.

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Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages von Fonseca, Gregory J., Tao, Jenhan, Westin, Emma M., Duttke, Sascha H., Spann, Nathanael J., Strid, Tobias, Shen, Zeyang, Stender, Joshua D., Sakai, Mashito, Link, Verena M., Benner, Christopher, Glass, Christopher K.

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SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus von Branche, Emilie, Wang, Ying-Ting, Viramontes, Karla M., Valls Cuevas, Joan M., Xie, Jialei, Ana-Sosa-Batiz, Fernanda, Shafee, Norazizah, Duttke, Sascha H., McMillan, Rachel E., Clark, Alex E., Nguyen, Michael N., Garretson, Aaron F., Crames, Jan J., Spann, Nathan J., Zhu, Zhe, Rich, Jeremy N., Spector, Deborah H., Benner, Christopher, Shresta, Sujan, Carlin, Aaron F.

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Transcription factor ISL1 is essential for pacemaker development and function von Liang, Xingqun, Zhang, Qingquan, Cattaneo, Paola, Zhuang, Shaowei, Gong, Xiaohui, Spann, Nathanael J, Jiang, Cizhong, Cao, Xinkai, Zhao, Xiaodong, Zhang, Xiaoli, Bu, Lei, Wang, Gang, Chen, H S Vincent, Zhuang, Tao, Yan, Jie, Geng, Peng, Luo, Lina, Banerjee, Indroneal, Chen, Yihan, Glass, Christopher K, Zambon, Alexander C, Chen, Ju, Sun, Yunfu, Evans, Sylvia M

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Sterols and oxysterols in immune cell function von Spann, Nathanael J, Glass, Christopher K

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Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages von Eichenfield, Dawn Z, Troutman, Ty Dale, Link, Verena M, Lam, Michael T, Cho, Han, Gosselin, David, Spann, Nathanael J, Lesch, Hanna P, Tao, Jenhan, Muto, Jun, Gallo, Richard L, Evans, Ronald M, Glass, Christopher K

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Systematic analysis of naturally occurring insertions and deletions that alter transcription factor spacing identifies tolerant and sensitive transcription factor pairs von Shen, Zeyang, Li, Rick Z, Prohaska, Thomas A, Hoeksema, Marten A, Spann, Nathan J, Tao, Jenhan, Fonseca, Gregory J, Le, Thomas, Stolze, Lindsey K, Sakai, Mashito, Romanoski, Casey E, Glass, Christopher K

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Txnip balances metabolic and growth signaling via PTEN disulfide reduction von Hui, Simon T.Y, Andres, Allen M, Miller, Amber K, Spann, Nathanael J, Potter, Douglas W, Post, Noah M, Chen, Amelia Z, Sachithanantham, Sowbarnika, Jung, Dae Young, Kim, Jason K, Davis, Roger A

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ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge’s disease von Azad, Priti, Caldwell, Andrew B., Ramachandran, Srinivasan, Spann, Nathanael J., Akbari, Ali, Villafuerte, Francisco C., Bermudez, Daniela, Zhao, Helen, Poulsen, Orit, Zhou, Dan, Bafna, Vineet, Subramaniam, Shankar, Haddad, Gabriel G.

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