Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms von Spangler, Jamie B., Tomala, Jakub, Luca, Vincent C., Jude, Kevin M., Dong, Shen, Ring, Aaron M., Votavova, Petra, Pepper, Marion, Kovar, Marek, Garcia, K. Christopher

Volltext

Engineering the IL-4/IL-13 axis for targeted immune modulation von Bernstein, Zachary J, Shenoy, Anjali, Chen, Amy, Heller, Nicola M, Spangler, Jamie B

Volltext

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps von Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.

Volltext

Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors von Ray, Christina M P, Yang, Huilin, Spangler, Jamie B, Mac Gabhann, Feilim

Volltext

Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy von Isser, Ariel, Silver, Aliyah B., Pruitt, Hawley C., Mass, Michal, Elias, Emma H., Aihara, Gohta, Kang, Si-Sim, Bachmann, Niklas, Chen, Ying-Yu, Leonard, Elissa K., Bieler, Joan G., Chaisawangwong, Worarat, Choy, Joseph, Shannon, Sydney R., Gerecht, Sharon, Weber, Jeffrey S., Spangler, Jamie B., Schneck, Jonathan P.

Volltext

Strategies for Glycoengineering Therapeutic Proteins von Dammen-Brower, Kris, Epler, Paige, Zhu, Stanley, Bernstein, Zachary J, Stabach, Paul R, Braddock, Demetrios T, Spangler, Jamie B, Yarema, Kevin J

Volltext

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling von Spangler, Jamie B., Neil, Jason R., Abramovitch, Sivan, Yarden, Yosef, White, Forest M., Lauffenburger, Douglas A., Wittrup, K. Dane, Kuriyan, John

Volltext

Poly(Beta-Amino Ester)s as High-Yield Transfection Reagents for Recombinant Protein Production von Luly, Kathryn M, Yang, Huilin, Lee, Stephen J, Wang, Wentao, Ludwig, Seth D, Tarbox, Haley E, Wilson, David R, Green, Jordan J, Spangler, Jamie B

Volltext

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers von Moraga, Ignacio, Spangler, Jamie B, Mendoza, Juan L, Gakovic, Milica, Wehrman, Tom S, Krutzik, Peter, Garcia, K Christopher

Volltext

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function von Sun, Hao, Lee, Ho-Sup, Kim, Sarah Hyun-Ji, Fernandes de Lima, Mikhael, Gingras, Alexandre R., Du, Qinyi, McLaughlin, Wilma, Ablack, Jailail, Lopez-Ramirez, Miguel A., Lagarrigue, Frederic, Fan, Zhichao, Chang, John T., VanDyke, Derek, Spangler, Jamie B., Ginsberg, Mark H.

Volltext

Insights into Cytokine-Receptor Interactions from Cytokine Engineering von Spangler, Jamie B, Moraga, Ignacio, Mendoza, Juan L, Garcia, K. Christopher

Volltext

A versatile design platform for glycoengineering therapeutic antibodies von Ludwig, Seth D, Bernstein, Zachary J, Agatemor, Christian, Dammen-Brower, Kris, Ruffolo, Jeffrey, Rosas, Jonah M, Post, Jeremy D, Cole, Robert N, Yarema, Kevin J, Spangler, Jamie B

Volltext

Engineering Anticytokine Antibodies for Immune Modulation von Tomala, Jakub, Cao, Shanelle D, Spangler, Jamie B

Volltext

Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin von SPANGLER, B. D

Volltext

Empowering gene delivery with protein engineering platforms von Kizerwetter, Monika, Pietz, Kevin, Tomasovic, Luke M., Spangler, Jamie B.

Volltext

Engineered antibody fusion proteins for targeted disease therapy von Silver, Aliyah B., Leonard, Elissa K., Gould, Joseph R., Spangler, Jamie B.

Volltext

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells von Glassman, Caleb R., Mathiharan, Yamuna Kalyani, Jude, Kevin M., Su, Leon, Panova, Ouliana, Lupardus, Patrick J., Spangler, Jamie B., Ely, Lauren K., Thomas, Christoph, Skiniotis, Georgios, Garcia, K. Christopher

Volltext

Insights into the anticancer mechanisms of interleukin-15 from engineered cytokine therapies von Bernstein, Zachary J, Spangler, Jamie B

Volltext

The relationship between multimorbidity, obesity and functional impairment in older adults von Lynch, David H., Petersen, Curtis L., Fanous, Marco M., Spangler, Hillary B., Kahkoska, Anna R., Jimenez, Daniel, Batsis, John A.

Volltext

Joined at the hip: The role of light chain complementarity determining region 2 in antibody self-association von Sargunas, Paul R., Spangler, Jamie B.

Volltext