Discovery of a structural class of antibiotics with explainable deep learning von Wong, Felix, Zheng, Erica J., Valeri, Jacqueline A., Donghia, Nina M., Anahtar, Melis N., Omori, Satotaka, Li, Alicia, Cubillos-Ruiz, Andres, Krishnan, Aarti, Jin, Wengong, Manson, Abigail L., Friedrichs, Jens, Helbig, Ralf, Hajian, Behnoush, Fiejtek, Dawid K., Wagner, Florence F., Soutter, Holly H., Earl, Ashlee M., Stokes, Jonathan M., Renner, Lars D., Collins, James J.

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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library von Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.

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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of In... von Lee, Katherine L, Ambler, Catherine M, Anderson, David R, Boscoe, Brian P, Bree, Andrea G, Brodfuehrer, Joanne I, Chang, Jeanne S, Choi, Chulho, Chung, Seungwon, Curran, Kevin J, Day, Jacqueline E, Dehnhardt, Christoph M, Dower, Ken, Drozda, Susan E, Frisbie, Richard K, Gavrin, Lori K, Goldberg, Joel A, Han, Seungil, Hegen, Martin, Hepworth, David, Hope, Heidi R, Kamtekar, Satwik, Kilty, Iain C, Lee, Arthur, Lin, Lih-Ling, Lovering, Frank E, Lowe, Michael D, Mathias, John P, Morgan, Heidi M, Murphy, Elizabeth A, Papaioannou, Nikolaos, Patny, Akshay, Pierce, Betsy S, Rao, Vikram R, Saiah, Eddine, Samardjiev, Ivan J, Samas, Brian M, Shen, Marina W. H, Shin, Julia H, Soutter, Holly H, Strohbach, Joseph W, Symanowicz, Peter T, Thomason, Jennifer R, Trzupek, John D, Vargas, Richard, Vincent, Fabien, Yan, Jiangli, Zapf, Christoph W, Wright, Stephen W

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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa von Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology von Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn M., Sigel, Eric A., Troast, Dawn M., Zhang, Ying, Ferguson, Andrew D., Davies, Gareth, Stead, Eleanor R., Breed, Jason, Madhavapeddi, Prashanti, Read, Jon A.

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Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action von Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás

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Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors von Johannes, Jeffrey W., Bates, Stephanie, Beigie, Carl, Belmonte, Matthew A., Breen, John, Cao, Shenggen, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Ferguson, Andrew D., Habeshian, Sevan, Hargreaves, David, Joubran, Camil, Kazmirski, Steven, Keefe, Anthony D., Lamb, Michelle L., Lan, Haiye, Li, Yunxia, Ma, Hao, Mlynarski, Scott, Packer, Martin J., Rawlins, Philip B., Robbins, Daniel W., Shen, Haidong, Sigel, Eric A., Soutter, Holly H., Su, Nancy, Troast, Dawn M., Wang, Haiyun, Wickson, Kate F., Wu, Chengyan, Zhang, Ying, Zhao, Qiuying, Zheng, Xiaolan, Hird, Alexander W.

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Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation von Choi, Jun Yong, Plummer, Mark S, Starr, Jeremy, Desbonnet, Charlene R, Soutter, Holly, Chang, Jeanne, Miller, J. Richard, Dillman, Keith, Miller, Alita A, Roush, William R

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Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening von Cuozzo, John W., Soutter, Holly H.

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The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS) von Jiang, Wei, Soutter, Holly

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Fragment-Based Screen against HIV Protease von Perryman, Alexander L, Zhang, Qing, Soutter, Holly H, Rosenfeld, Robin, McRee, Duncan E, Olson, Arthur J, Elder, John E, David Stout, C

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Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library von Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.

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Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target von Brown, Dean G., Brown, Giles A., Centrella, Paolo, Certel, Kaan, Cooke, Robert M., Cuozzo, John W., Dekker, Niek, Dumelin, Christoph E., Ferguson, Andrew, Fiez-Vandal, Cédric, Geschwindner, Stefan, Guié, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Schlenker, Oliver, Sigel, Eric A., Snijder, Arjan, Soutter, Holly T., Sundström, Linda, Troast, Dawn M., Wiggin, Giselle, Zhang, Jing, Zhang, Ying, Clark, Matthew A.

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Inside Cover: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library (ChemBioChem 9/2017) von Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.

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Correction to “Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors” von Johannes, Jeffrey W, Bates, Stephanie, Beigie, Carl, Belmonte, Matthew A, Breen, John, Cao, Shenggen, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Ferguson, Andrew D, Habeshian, Sevan, Hargreaves, David, Joubran, Camil, Kazmirski, Steven, Keefe, Anthony D, Lamb, Michelle L, Lan, Haiye, Li, Yunxia, Ma, Hao, Mlynarski, Scott, Packer, Martin J, Rawlins, Philip B, Robbins, Daniel W, Shen, Haidong, Sigel, Eric A, Soutter, Holly H, Su, Nancy, Troast, Dawn M, Wang, Haiyun, Wickson, Kate F, Wu, Chengyan, Zhang, Ying, Zhao, Qiuying, Zheng, Xiaolan, Hird, Alexander W

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Structural insight into allosteric modulation of protease-activated receptor 2 von Cheng, Robert K. Y., Fiez-Vandal, Cédric, Schlenker, Oliver, Edman, Karl, Aggeler, Birte, Brown, Dean G., Brown, Giles A., Cooke, Robert M., Dumelin, Christoph E., Doré, Andrew S., Geschwindner, Stefan, Grebner, Christoph, Hermansson, Nils-Olov, Jazayeri, Ali, Johansson, Patrik, Leong, Louis, Prihandoko, Rudi, Rappas, Mathieu, Soutter, Holly, Snijder, Arjan, Sundström, Linda, Tehan, Benjamin, Thornton, Peter, Troast, Dawn, Wiggin, Giselle, Zhukov, Andrei, Marshall, Fiona H., Dekker, Niek

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Abstract 5331: DNA-encoded macrocyclic compound libraries for challenging targets von Zhang, Ying, Keefe, Anthony, Centrella, Paolo, Cuozzo, John, Soutter, Holly, Resnicow, Daniel, Habeshian, Sevan, Clark, Matt

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Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy von Kulkarni, Meghana M, Dwight, Timothy, Marino, Kristen, Allen, Bryce K, Taimi, Mohammed, Bastos, Cecilia, Lai, Sujen, Koh, Cheryl, Samant, Ramya, Tesar, Bethany, Huang, Huang, Chamberlain, Brian, Rice, James M, Tan, Dazhi, Lin, Zhixiong, Shechter, Sharon, Li, Stella, Sparks, Sam, Soutter, Holly, Swann, Steven, Sherman, Woody, Winter, Christopher

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Imidazo[1,5- a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis von Kim, Kyung-Hee, Maderna, Andreas, Schnute, Mark E., Hegen, Martin, Mohan, Shashi, Miyashiro, Joy, Lin, Laura, Li, Evelyn, Keegan, Sean, Lussier, Jennifer, Wrocklage, Christopher, Nickerson-Nutter, Cheryl L., Wittwer, Arthur J., Soutter, Holly, Caspers, Nicole, Han, Seungil, Kurumbail, Ravi, Dunussi-Joannopoulos, Kyri, Douhan, John, Wissner, Allan

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Abstract 5084: Potent and isoform-selective ATAD2 bromodomain inhibitor with unprecedented chemical structure and mode of action von Fernández-Montalván, Amaury E., Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Holton, Simon J., Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James, Federov, Oleg, Huber, Kilian, Centrella, Paolo, Clark, Matthew A., Dumelin, Christoph E., Sigel, Eric A., Soutter, Holly S., Troast, Dawn M., Zhang, Ying, Cuozzo, John W., Keefe, Anthony D., Roche, Didier, Rodeschini, Vincent, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V., Gorjanacz, Matyas

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