Client-Loading Conformation of the Hsp90 Molecular Chaperone Revealed in the Cryo-EM Structure of the Human Hsp90:Hop Complex von Southworth, Daniel R., Agard, David A.

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Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation von Assimon, Victoria A, Southworth, Daniel R, Gestwicki, Jason E

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Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 von Gates, Stephanie N., Yokom, Adam L., Lin, JiaBei, Jackrel, Meredith E., Rizo, Alexandrea N., Kendsersky, Nathan M., Buell, Courtney E., Sweeny, Elizabeth A., Mack, Korrie L., Chuang, Edward, Torrente, Mariana P., Su, Min, Shorter, James, Southworth, Daniel R.

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Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments von Merz, Gregory E., Chalkley, Matthew J., Tan, Sophia K., Tse, Eric, Lee, Joanne, Prusiner, Stanley B., Paras, Nick A., DeGrado, William F., Southworth, Daniel R.

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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state von Lee, Kanghyun, Thwin, Aye C., Nadel, Cory M., Tse, Eric, Gates, Stephanie N., Gestwicki, Jason E., Southworth, Daniel R.

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Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase von Rizo, Alexandrea N., Lin, JiaBei, Gates, Stephanie N., Tse, Eric, Bart, Stephen M., Castellano, Laura M., DiMaio, Frank, Shorter, James, Southworth, Daniel R.

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Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau von Freilich, Rebecca, Betegon, Miguel, Tse, Eric, Mok, Sue-Ann, Julien, Olivier, Agard, David A., Southworth, Daniel R., Takeuchi, Koh, Gestwicki, Jason E.

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Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation von Yokom, Adam L, Gates, Stephanie N, Jackrel, Meredith E, Mack, Korrie L, Su, Min, Shorter, James, Southworth, Daniel R

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Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils von Huettemann, Philipp, Mahadevan, Pavithra, Lempart, Justine, Tse, Eric, Dehury, Budheswar, Edwards, Brian F P, Southworth, Daniel R, Sahoo, Bikash R, Jakob, Ursula

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The Protein Targeting Factor Get3 Functions as ATP-Independent Chaperone under Oxidative Stress Conditions von Voth, Wilhelm, Schick, Markus, Gates, Stephanie, Li, Sheng, Vilardi, Fabio, Gostimskaya, Irina, Southworth, Daniel R., Schwappach, Blanche, Jakob, Ursula

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Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements von Shiau, Andrew K., Harris, Seth F., Southworth, Daniel R., Agard, David A.

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Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP von Nadel, Cory M., Pokhrel, Saugat, Wucherer, Kristin, Oehler, Abby, Thwin, Aye C., Basu, Koli, Callahan, Matthew D., Southworth, Daniel R., Mordes, Daniel A., Craik, Charles S., Gestwicki, Jason E.

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Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum von Teixeira, Filipa, Castro, Helena, Cruz, Tânia, Tse, Eric, Koldewey, Philipp, Southworth, Daniel R, Tomás, Ana M, Jakob, Ursula

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Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase von Shorter, James, Southworth, Daniel R

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Chaperone activation and client binding of a 2-cysteine peroxiredoxin von Teixeira, Filipa, Tse, Eric, Castro, Helena, Makepeace, Karl A. T., Meinen, Ben A., Borchers, Christoph H., Poole, Leslie B., Bardwell, James C., Tomás, Ana M., Southworth, Daniel R., Jakob, Ursula

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Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy von Ewens, Caroline A., Su, Min, Zhao, Liang, Nano, Nardin, Houry, Walid A., Southworth, Daniel R.

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KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation von Shukla, Shirish, Allam, Uday Sankar, Ahsan, Aarif, Chen, Guoan, Krishnamurthy, Pranathi Meda, Marsh, Katherine, Rumschlag, Matthew, Shankar, Sunita, Whitehead, Christopher, Schipper, Matthew, Basrur, Venkatesha, Southworth, Daniel R, Chinnaiyan, Arul M, Rehemtulla, Alnawaz, Beer, David G, Lawrence, Theodore S, Nyati, Mukesh K, Ray, Dipankar

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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity von Tariq, Amber, Lin, JiaBei, Jackrel, Meredith E., Hesketh, Christina D., Carman, Peter J., Mack, Korrie L., Weitzman, Rachel, Gambogi, Craig, Hernandez Murillo, Oscar A., Sweeny, Elizabeth A., Gurpinar, Esin, Yokom, Adam L., Gates, Stephanie N., Yee, Keolamau, Sudesh, Saurabh, Stillman, Jacob, Rizo, Alexandra N., Southworth, Daniel R., Shorter, James

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Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold von Ghosh, Ujjayini, Tse, Eric, Yang, Hyunjun, Shi, Marie, Caro, Christoffer D, Wang, Feng, Merz, Gregory E, Prusiner, Stanley B, Southworth, Daniel R, Condello, Carlo

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Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality von Braxton, Julian R., Southworth, Daniel R.

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