Genome-editing technologies and patent landscape overview von Benahmed-Miniuk, Fairouz, Kresz, Mat, Kanaujiya, Jitendra K, Southgate, Christopher D

Volltext

The Type 1 Human Immunodeficiency Virus Tat Binding Protein is a Transcriptional Activator Belonging to an Additional Family of Evolutionarily Conserved Genes von Ohana, Bella, Moore, Paul A., Ruben, Steven M., Southgate, Christopher D., Green, Michael R.

Volltext

Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton von Southgate, Christopher D., Chishti, Athar H., Mitchell, Betsy, Yi, Scott J., Palek, Jiri

Volltext

The HIV-1 Tat protein activates transcription from an upstream DNA-binding site : implications for Tat function von SOUTHGATE, C. D, GREEN, M. R

Volltext

Delineating minimal protein domains and promoter elements for transcriptional activation by lentivirus Tat proteins von Southgate, C D, Green, M R

Volltext

SARS-CoV-2 evolution during treatment of chronic infection von Kemp, Steven A., Collier, Dami A., Datir, Rawlings P., Ferreira, Isabella A. T. M., Gayed, Salma, Jahun, Aminu, Hosmillo, Myra, Rees-Spear, Chloe, Mlcochova, Petra, Lumb, Ines Ushiro, Roberts, David J., Chandra, Anita, Temperton, Nigel, Sharrocks, Katherine, Blane, Elizabeth, Modis, Yorgo, Leigh, Kendra E., Briggs, John A. G., van Gils, Marit J., Smith, Kenneth G. C., Bradley, John R., Smith, Chris, Doffinger, Rainer, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Pollock, David D., Goldstein, Richard A., Smielewska, Anna, Skittrall, Jordan P., Gouliouris, Theodore, Goodfellow, Ian G., Gkrania-Klotsas, Effrossyni, Illingworth, Christopher J. R., McCoy, Laura E., Gupta, Ravindra K.

Volltext

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension von Gräf, Stefan, Haimel, Matthias, Bleda, Marta, Hadinnapola, Charaka, Southgate, Laura, Li, Wei, Hodgson, Joshua, Liu, Bin, Salmon, Richard M., Southwood, Mark, Machado, Rajiv D., Martin, Jennifer M., Treacy, Carmen M., Yates, Katherine, Daugherty, Louise C., Shamardina, Olga, Whitehorn, Deborah, Holden, Simon, Aldred, Micheala, Bogaard, Harm J., Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A., Danesino, Cesare, Eyries, Mélanie, Gall, Henning, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J. Simon R., Girerd, Barbara, Houweling, Arjan C., Howard, Luke, Humbert, Marc, Kiely, David G., Kovacs, Gabor, MacKenzie Ross, Robert V., Moledina, Shahin, Montani, David, Newnham, Michael, Olschewski, Andrea, Olschewski, Horst, Peacock, Andrew J., Pepke-Zaba, Joanna, Prokopenko, Inga, Rhodes, Christopher J., Scelsi, Laura, Seeger, Werner, Soubrier, Florent, Stein, Dan F., Suntharalingam, Jay, Swietlik, Emilia M., Toshner, Mark R., van Heel, David A., Vonk Noordegraaf, Anton, Waisfisz, Quinten, Wharton, John, Wort, Stephen J., Ouwehand, Willem H., Soranzo, Nicole, Lawrie, Allan, Upton, Paul D., Wilkins, Martin R., Trembath, Richard C., Morrell, Nicholas W.

Volltext

CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells von Southgate, Thomas D, McGinn, Owen J, Castro, Fernanda V, Rutkowski, Andrzej J, Al-Muftah, Mariam, Marinov, Georgi, Smethurst, Graeme J, Shaw, David, Ward, Christopher M, Miller, Crispin J, Stern, Peter L

Volltext

Deriving a dose and regimen for anti-glucosaminidase antibody passive-immunisation for patients with Staphylococcus aureus osteomyelitis von Lee, C C, Southgate, R D, Jiao, C, Gersz, E, Owen, J R, Kates, S L, Beck, C A, Xie, C, Daiss, J L, Post, V, Moriarty, T F, Zeiter, S, Schwarz, E M, Muthukrishnan, G

Volltext

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity von Shepherd, James, Koshy, Cherian, Wise, Emma, Curran, Tanya, Adams, Helen, Moore, Catrin, Khokhar, Fahad A., Reynolds, Nicola, Afifi, Safiah, Price, Anna, Kitchen, Christine, Merrick, Ian, Connor, Thomas R., Bresner, Catherine, Robson, Samuel C., Menegazzo, Mirko, Clark, Gemma, Fleming, Vicki M., Howson-Wells, Hannah C., Bird, Paul, Helmer, Thomas, Fallon, Karlie, du Plessis, Louis, Attwood, Stephen, Vasylyeva, Tetyana, Chaudhry, Yasmin, Moses, Samuel, Ryan, Felicity, Brown, Julianne Rose, Lee, Jack C.D., Alcolea-Medina, Adela, Moore, Nathan, Cortes, Nicholas, Williams, Rebecca, Smith, Darren L., Holmes, Alison, Price, James, Rowan, Aileen, Taylor, Graham P., Watts, Joanne, Ludden, Catherine, George, Ryan P., Li, Kathy K., Carmichael, Stephen N., Johnson, Natasha, Orton, Richard J., Hale, Antony D., Harper, Katherine L., Eltringham, Gary, Coupland, Lindsay J., Barton, Edward, Scott, Garren, Yew, Wen C., Resende Silva, Paola C., Justice, Anita, Chand, Meera, Williams, David, Harrison, Ian, Chalker, Vicki, Heyburn, David, Downing, Fatima, Watkins, Joanne, Howe, Robin, Taylor, Sarah, Wain, John, Rudder, Steven, Gilroy, Rachel A.J., Alikhan, Nabil-Fareed, Casey, Anna, Liggett, Steven, Caller, Laura G., Panchbhaya, Yasmin N., Forrest, Leysa M., Findlay, Jacqueline, Beggs, Andrew, Hesketh, Andrew R., Higginson, Ellen E., Aggarwal, Dinesh, Colquhoun, Rachel, Ashworth, Jordan, McCrone, J.T., Michell, Stephen L., Hughes, Margaret, Rainbow, Lucille, Haldenby, Sam T., Green, Luke R., Parker, Matthew D., Bridgewater, Hannah E., Alam, Mohammad T., Quail, Mike, Thurston, Scott, Beaver, Charlotte, McMinn, Liz, Puethe, Christoph, Tonkin-Hill, Gerry, Smith, Christen, Jamrozy, Dorota, Patel, Minal, Drury, Eleanor, Loman, Nicholas J.

Volltext

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome von Rhodes, Christopher J, Otero-Núñez, Pablo, Wharton, John, Swietlik, Emilia M, Kariotis, Sokratis, Harbaum, Lars, Dunning, Mark J, Elinoff, Jason M, Errington, Niamh, Thompson, A A Roger, Iremonger, James, Coghlan, J Gerry, Corris, Paul A, Howard, Luke S, Kiely, David G, Church, Colin, Pepke-Zaba, Joanna, Toshner, Mark, Wort, Stephen J, Desai, Ankit A, Humbert, Marc, Nichols, William C, Southgate, Laura, Trégouët, David-Alexandre, Trembath, Richard C, Prokopenko, Inga, Gräf, Stefan, Morrell, Nicholas W, Wang, Dennis, Lawrie, Allan, Wilkins, Martin R

Volltext

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension von Hodgson, Joshua, Swietlik, Emilia M, Salmon, Richard M, Hadinnapola, Charaka, Nikolic, Ivana, Wharton, John, Guo, Jingxu, Liley, James, Haimel, Matthias, Bleda, Marta, Southgate, Laura, Machado, Rajiv D, Martin, Jennifer M, Treacy, Carmen M, Yates, Katherine, Daugherty, Louise C, Shamardina, Olga, Whitehorn, Deborah, Holden, Simon, Bogaard, Harm J, Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A, Danesino, Cesare, Eyries, Mélanie, Gall, Henning, Ghio, Stefano, Ghofrani, Hossein-Ardeschir, Gibbs, J Simon R, Girerd, Barbara, Houweling, Arjan C, Howard, Luke, Humbert, Marc, Kiely, David G, Kovacs, Gabor, Lawrie, Allan, MacKenzie Ross, Robert V, Moledina, Shahin, Montani, David, Olschewski, Andrea, Olschewski, Horst, Ouwehand, Willem H, Peacock, Andrew J, Pepke-Zaba, Joanna, Prokopenko, Inga, Rhodes, Christopher J, Scelsi, Laura, Seeger, Werner, Soubrier, Florent, Suntharalingam, Jay, Toshner, Mark R, Trembath, Richard C, Vonk Noordegraaf, Anton, Wort, Stephen J, Wilkins, Martin R, Yu, Paul B, Li, Wei, Gräf, Stefan, Upton, Paul D, Morrell, Nicholas W

Volltext

Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension von Harbaum, Lars, Rhodes, Christopher J, Wharton, John, Lawrie, Allan, Karnes, Jason H, Desai, Ankit A, Nichols, William C, Humbert, Marc, Montani, David, Girerd, Barbara, Sitbon, Olivier, Boehm, Mario, Novoyatleva, Tatyana, Schermuly, Ralph T, Ghofrani, H Ardeschir, Toshner, Mark, Kiely, David G, Howard, Luke S, Swietlik, Emilia M, Gräf, Stefan, Pietzner, Maik, Morrell, Nicholas W, Wilkins, Martin R

Volltext

E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells von Spencer, Helen L, Eastham, Angela M, Merry, Catherine L R, Southgate, Thomas D, Perez-Campo, Flor, Soncin, Francesca, Ritson, Sarah, Kemler, Rolf, Stern, Peter L, Ward, Christopher M

Volltext

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension von Hadinnapola, Charaka, Bleda, Marta, Haimel, Matthias, Screaton, Nicholas, Swift, Andrew, Dorfmüller, Peter, Preston, Stephen D, Southwood, Mark, Hernandez-Sanchez, Jules, Martin, Jennifer, Treacy, Carmen, Yates, Katherine, Bogaard, Harm, Church, Colin, Coghlan, Gerry, Condliffe, Robin, Corris, Paul A, Gibbs, Simon, Girerd, Barbara, Holden, Simon, Humbert, Marc, Kiely, David G, Lawrie, Allan, Machado, Rajiv, MacKenzie Ross, Robert, Moledina, Shahin, Montani, David, Newnham, Michael, Peacock, Andrew, Pepke-Zaba, Joanna, Rayner-Matthews, Paula, Shamardina, Olga, Soubrier, Florent, Southgate, Laura, Suntharalingam, Jay, Toshner, Mark, Trembath, Richard, Vonk Noordegraaf, Anton, Wilkins, Martin R, Wort, Stephen J, Wharton, John, Gräf, Stefan, Morrell, Nicholas W

Volltext

Defining the clinical validity of genes reported to cause pulmonary arterial hypertension von Welch, Carrie L., Aldred, Micheala A., Balachandar, Srimmitha, Dooijes, Dennis, Eichstaedt, Christina A., Gräf, Stefan, Houweling, Arjan C., Machado, Rajiv D., Pandya, Divya, Prapa, Matina, Shaukat, Memoona, Southgate, Laura, Tenorio-Castano, Jair, Callejo, Emily P., Day, Kristina M., Macaya, Daniela, Maldonado-Velez, Gabriel, Chung, Wendy K., Archer, Stephen L., Auckland, Kathryn, Austin, Eric D., Badagliacca, Roberto, Barberà, Joan-Albert, Belge, Catharina, Bogaard, Harm Jan, Bonnet, Sébastien, Boomars, Karin A., Boucherat, Olivier, Chakinala, Murali M., Condliffe, Robin, Damico, Rachel Lynn, Delcroix, Marion, Desai, Ankit A., Doboszynska, Anna, Elliott, C. Greg, Eyries, Melanie, Escribano Subías, Maria Pilar, Gall, Henning, Ghio, Stefano, Ghofrani, Ardeschir-Hossein, Grünig, Ekkehard, Hamid, Rizwan, Harbaum, Lars, Hassoun, Paul M., Hemnes, Anna R., Hinderhofer, Katrin, Howard, Luke S., Humbert, Marc, Kiely, David G., Langleben, David, Lawrie, Allan, Loyd, Jim E., Moledina, Shahin, Montani, David, Morrell, Nichols W., Nichols, William C., Olschewski, Andrea, Olschewski, Horst, Papa, Silvia, Pauciulo, Mike W., Provencher, Steve, Quarck, Rozenn, Rhodes, Christopher J., Scelsi, Laura, Seeger, Werner, Stewart, Duncan J., Sweatt, Andrew, Swietlik, Emilia M., Treacy, Carmen, Trembath, Richard C., Tura-Ceide, Olga, Vizza, Carmine Dario, Vonk Noordegraaf, Anton, Wilkins, Martin R., Zamanian, Roham T., Zateyshchikov, Dmitry

Volltext

Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study von Graham, Mark S, Sudre, Carole H, Ash, Amy, Moore, Nathan, Golubchik, Tanya, Spellman, Karla, Fuller, William, Nebbia, Gaia, Taylor, Ben EW, Willingham, Iona, Sheriff, Nicola, Moore, Christopher, Debebe, Johnny, Wilson, Harry D, Davis, Thomas, Pybus, Oliver G, Raghwani, Jayna, Heaney, Judith, Smith, Darren L, Jorgensen, David, Siveroni, Igor, Boyd, Olivia, Smollett, Katherine L, Quick, Joshua, Halstead, Fenella, Sivaprakasam, Venkat, Illingworth, Chris J, Jesudason, Natasha G, Johnson, Natasha, Robertson, David L, Taha, Yusri, Blacow, Rachel, McHugh, Martin P, Dewar, Rebecca, Stanley, Rachael, Peto, Timothy, Elliott, Scott, Pearson, Clare, Osman, Husam, Robinson, Esther, Mbisa, Tamyo, Bibby, David, Hubb, Jonathan, Lee, David, Manesis, Nikos, Bishop, Chloe, Shaaban, Sharif, Morgan, Mari, Cronin, Michelle, Corden, Sally, Page, Andrew J, Baker, David J, Meadows, Lizzie, Molnar, Zoltan, Acheson, Erwan, Masoli, Jane AH, Ellard, Sian, Irish-Tavares, Dianne, Dent, Hannah, Partridge, David G, Raza, Mohammad, Evans, Cariad, Essex, Sarah, Silveira, Siona, Jones, Katie, Percival, Benita, Mirza, Jeremy, Ashcroft, Fiona, Bucca, Giselda, Forrest, Sally, Maes, Mailis, Hadjirin, Nazreen F, Balcazar, Carlos E, Hill, Verity, Michell, Stephen L, Manley, Robin, Sambles, Christine M, Hiscox, Julian A, Gregory, Richard, Wierzbicki, Claudia, Lindsey, Benjamin B, Groves, Danielle C, Cheng, Jeffrey K.J., Brown, Paul E, Wilson, Rebekah E, McClure, Patrick C, Alderton, Alex, Amato, Roberto, Beale, Mathew A, Bellis, Katherine L, Harrison, Ewan M, Jackson, David K, Kwiatkowski, Dominic, Livett, Rich, McGuigan, Samantha, Prestwood, Liam, Shirley, Lesley, Tonkin-Hill, Gerry, Bronner, Iraad F, Tovar-Corona, Jaime M

Volltext

Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH von Zhu, Na, Swietlik, Emilia M, Welch, Carrie L, Pauciulo, Michael W, Hagen, Jacob J, Zhou, Xueya, Guo, Yicheng, Karten, Johannes, Pandya, Divya, Tilly, Tobias, Lutz, Katie A, Martin, Jennifer M, Treacy, Carmen M, Rosenzweig, Erika B, Krishnan, Usha, Coleman, Anna W, Gonzaga-Jauregui, Claudia, Lawrie, Allan, Trembath, Richard C, Wilkins, Martin R, Morrell, Nicholas W, Shen, Yufeng, Gräf, Stefan, Nichols, William C, Chung, Wendy K

Volltext

Factors Impacting Musculoskeletal Knowledge and Clinical Confidence in Graduating Medical Students von DiGiovanni, Benedict F, Southgate, Richard D, Mooney, Christopher J, Chu, Jennifer Y, Lambert, David R, O’Keefe, Regis J

Volltext

Implementation of the I-PASS handoff program in diverse clinical environments: A multicenter prospective effectiveness implementation study von Starmer, Amy J, Spector, Nancy D, O'Toole, Jennifer K, Bismilla, Zia, Calaman, Sharon, Campos, Maria-Lucia, Coffey, Maitreya, Destino, Lauren A, Everhart, Jennifer L, Goldstein, Jenna, Graham, Dionne A, Hepps, Jennifer H, Howell, Eric E, Kuzma, Nicholas, Maynard, Greg, Melvin, Patrice, Patel, Shilpa J, Popa, Alina, Rosenbluth, Glenn, Schnipper, Jeffrey L, Sectish, Theodore C, Srivastava, Rajendu, West, Daniel C, Yu, Clifton E, Landrigan, Christopher P

Volltext