The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy von Soucy, Teresa A, Dick, Lawrence R, Smith, Peter G, Milhollen, Michael A, Brownell, James E

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Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit von Blackburn, C., Gigstad, K. M., Hales, P., Garcia, K., Jones, M., Bruzzese, F. J., Barrett, C., Liu, J. X., Soucy, T. A., Sappal, D. S., Bump, N., Olhava, E. J., Fleming, P., Dick, L. R., Tsu, C., Sintchak, M. D., Blank, J. L.

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Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease von Therriault, Joseph, Servaes, Stijn, Tissot, Cécile, Rahmouni, Nesrine, Ashton, Nicholas J, Benedet, Andréa Lessa, Karikari, Thomas K, Macedo, Arthur C, Lussier, Firoza Z, Stevenson, Jenna, Wang, Yi-Ting, Fernandez-Arias, Jaime, Stevenson, Alyssa, Socualaya, Kely Quispialaya, Haeger, Arlette, Nazneen, Tahnia, Aumont, Étienne, Hosseini, Ali, Rej, Soham, Vitali, Paolo, Triana-Baltzer, Gallen, Kolb, Hartmuth C, Soucy, Jean-Paul, Pascoal, Tharick A, Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro

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Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer’s disease von Pascoal, T A, Mathotaarachchi, S, Mohades, S, Benedet, A L, Chung, C-O, Shin, M, Wang, S, Beaudry, T, Kang, M S, Soucy, J-P, Labbe, A, Gauthier, S, Rosa-Neto, P

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Biomarker modeling of Alzheimer's disease using PET-based Braak staging von Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L, Ashton, Nicholas J, Karikari, Thomas K, Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

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Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease von Kang, Min Su, Aliaga, Arturo Aliaga, Shin, Monica, Mathotaarachchi, Sulantha, Benedet, Andrea L., Pascoal, Tharick A., Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Devenyi, Gabriel A., Mathieu, Axel, Chakravarty, M. Mallar, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Soucy, Jean-Paul, Cuello, A. Claudio, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro

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Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages von Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

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Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging von Therriault, Joseph, Benedet, Andrea L, Pascoal, Tharick A, Savard, Melissa, Ashton, Nicholas J, Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Bezgin, Gleb, Wang, Tina, Fernandes-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Zetterberg, Henrik, Blennow, Kaj, Saha-Chaudhuri, Paramita, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

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Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials von Ferreira, Pamela, Ferrari-Souza, João Pedro, Tissot, Cécile, Bellaver, Bruna, Leffa, Douglas, Lussier, Firoza, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L, Ashton, Nicholas J, Cohen, Ann D., Lopez, Oscar L., Tudorascu, Dana, Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Villemagne, Victor, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro, Zimmer, Eduardo R., Karikari, Thomas K, Pascoal, Tharick

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Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic von Kang, Min Su, Shin, Monica, Ottoy, Julie, Aliaga, Arturo Aliaga, Mathotaarachchi, Sulantha, Quispialaya, Kely, Pascoal, Tharick A, Collins, D Louis, Chakravarty, M. Mallar, Mathieu, Axel, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Massarweh, Gassan, Soucy, Jean-Paul, Cuello, A Claudio, Gauthier, Serge, Waterston, Michael, Yoganathan, Nathan, Lessard, Etienne, Haqqani, Arsalan, Rennie, Kerry, Stanimirovic, Danica, Chakravarthy, Balu, Rosa-Neto, Pedro

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APOE ε4 associates with microglial activation independently of Aβ plaques and tau tangles von Ferrari-Souza, João Pedro, Lussier, Firoza Z, Leffa, Douglas T, Therriault, Joseph, Tissot, Cécile, Bellaver, Bruna, Ferreira, Pâmela C L, Malpetti, Maura, Wang, Yi-Ting, Povala, Guilherme, Benedet, Andréa L, Ashton, Nicholas J, Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, O'Brien, John T, Rowe, James B, Cohen, Ann D, Lopez, Oscar L, Tudorascu, Dana L, Karikari, Thomas K, Klunk, William E, Villemagne, Victor L, Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O, Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R, Rosa-Neto, Pedro, Pascoal, Tharick A

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The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target Regions von Tissot, C., Servaes, S., Lussier, F. Z., Ferrai-Souza, J. P., Therriault, J., Ferreirat, P. C., Bezgin, G., Bellaver, B., Leffa, D. T., Mathotaarachchi, S. S., Chamoun, M., Stevenson, J., Rahmouni, N., Kang, M. S., Pallen, V., Margherita-Poltronetti, N., Wang, Y. T., Fernandez-Arias, J., Lessa Benedet, Andréa, Zimmer, E. R., Soucy, J. P., Tudorascu, D. L., Cohen, A. D., Sharp, M., Gauthier, S., Massarweh, G., Lopresti, B., Klunk, W. E., Baker, S. L., Villemagne, V. L., Rosa-Neto, P., Pascoal, T. A.

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Amyloid-[beta] and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease von Pascoal, T A, Mathotaarachchi, S, Mohades, S, Benedet, A L, Chung, C-o, Shin, M, Wang, S, Beaudry, T, Kang, M S, Soucy, J-p, Labbe, A, Gauthier, S, Rosa-neto, P

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Amyloid-[beta] and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer%apos;s disease von Pascoal, T A, Mathotaarachchi, S, Mohades, S, Benedet, A L, Chung, C-O, Shin, M, Wang, S, Beaudry, T, Kang, M S, Soucy, J-P, Labbe, A, Gauthier, S, Rosa-Neto, P

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A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone von Soucy, François, Grenier, Louis, Behnke, Mark L, Destree, Antonia T, McCormack, Teresa A, Adams, Julian, Plamondon, Louis

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Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction von Armstrong, Paul W, Pieske, Burkert, Anstrom, Kevin J, Ezekowitz, Justin, Hernandez, Adrian F, Butler, Javed, Lam, Carolyn S.P, Ponikowski, Piotr, Voors, Adriaan A, Jia, Gang, McNulty, Steven E, Patel, Mahesh J, Roessig, Lothar, Koglin, Joerg, O’Connor, Christopher M

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Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes von Zhou, Xueya, Feliciano, Pamela, Shu, Chang, Wang, Tianyun, Astrovskaya, Irina, Hall, Jacob B., Obiajulu, Joseph U., Wright, Jessica R., Murali, Shwetha C., Xu, Simon Xuming, Brueggeman, Leo, Thomas, Taylor R., Marchenko, Olena, Fleisch, Christopher, Barns, Sarah D., Snyder, LeeAnne Green, Han, Bing, Chang, Timothy S., Turner, Tychele N., Harvey, William T., Nishida, Andrew, O’Roak, Brian J., Geschwind, Daniel H., Michaelson, Jacob J., Volfovsky, Natalia, Eichler, Evan E., Shen, Yufeng, Chung, Wendy K.

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Recent ultra-rare inherited variants implicate new autism candidate risk genes von Wilfert, Amy B., Turner, Tychele N., Murali, Shwetha C., Hsieh, PingHsun, Sulovari, Arvis, Wang, Tianyun, Coe, Bradley P., Guo, Hui, Hoekzema, Kendra, Bakken, Trygve E., Winterkorn, Lara H., Evani, Uday S., Byrska-Bishop, Marta, Earl, Rachel K., Bernier, Raphael A., Zody, Michael C., Eichler, Evan E.

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Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue von Dion-Albert, Laurence, Cadoret, Alice, Doney, Ellen, Kaufmann, Fernanda Neutzling, Dudek, Katarzyna A., Daigle, Beatrice, Parise, Lyonna F., Cathomas, Flurin, Samba, Nalia, Hudson, Natalie, Lebel, Manon, Campbell, Matthew, Turecki, Gustavo, Mechawar, Naguib, Menard, Caroline

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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer von Lee, JM, Dicks, E, Barrowdale, D, Aalfs, CM, Adlard, J, Azzollini, J, Bean, Y, Beckmann, MW, Bonanni, B, Bradbury, AR, Brunet, J, Caligo, MA, Chan, SB, Cook, LS, Cook, J, Cunningham, JM, Daly, MB, Dansonka-Mieszkowska, A, Delnatte, C, Dossus, L, Engel, C, Ferguson, S, Fostira, F, Friedman, E, Frost, D, Garber, J, Gentry-Maharaj, A, Giles, GG, Goranova, T, Greene, MH, Haiman, CA, Hakansson, N, Hamann, U, Hansen, TVO, Henderson, A, Huntsman, DG, Janavicius, R, Jernetz, M, Jones, ME, Kennedy, CJ, Khusnutdinova, E, Kiemeney, LA, Kupryjanczyk, J, Lambrechts, D, Le, ND, Lester, J, Lesueur, F, Levine, DA, Lipworth, L, May, T, Mazoyer, S, McNeish, I, Meijers-Heijboer, H, Mensenkamp, AR, Modugno, F, Musinsky, J, Nathanson, KL, Nedergaard, L, Ness, RB, Olah, E, Olopade, OI, Onland-Moret, NC, Orr, N, Osorio, A, Pedersen, IS, Pejovic, T, Permuth, JB, Phillips, K-A, Poblete, SR, Pocza, T, Porteous, ME, Prokofyeva, D, Rantala, J, Rennert, G, Rice, P, Richardson, A, Rossing, MA, Salvesen, HB, Siddiqui, N, Side, LE, Sukiennicki, G, Szabo, CI, Tinker, AV, Toland, AE, Travis, RC, Tung, N, Van der Luijt, RB, Vanderstichele, A, Walker, L, Wang-Gohrke, S, Whittemore, AS, Wilkens, LR, Woo, M, Zorn, KK, Amos, CI, Schildkraut, JM, Goodman, MT, Schmutzler, RK, Hazelett, D, Antoniou, AC

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