593 Strategies to overcome resistance to BET bromodomain inhibitor in KRAS/LKB1 mutant NSCLC von Soucheray, M, Kikuchi, E, Pulido, I, Akbay, E, Becker, J.H, Christensen, C.L, Johnson, N, Patel, T.B, Carretero, J, Wong, K.K, Shimamura, T

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Abstract P1-05-31: Studying the interactome of breast cancer: The cancer cell map initiative von Kim, M, Kim, K, Soucheray, M, Swaney, D, Krogan, N

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Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets von Haas, KM, McGregor, MJ, Bouhaddou, M, Polacco, BJ, Kim, E-Y, Nguyen, TT, Newton, BW, Urbanowski, M, Kim, H, Williams, MAP, Rezelj, VV, Hardy, A, Fossati, A, Stevenson, EJ, Sukerman, E, Kim, T, Penugonda, S, Moreno, E, Braberg, H, Zhou, Y, Metreveli, G, Harjai, B, Tummino, TA, Melnyk, JE, Soucheray, M, Batra, J, Pache, L, Martin-Sancho, L, Carlson-Stevermer, J, Jureka, AS, Basler, CF, Shokat, KM, Shoichet, BK, Shriver, LP, Johnson, JR, Shaw, ML, Chanda, SK, Roden, DM, Carter, TC, Kottyan, LC, Chisholm, RL, Pacheco, JA, Smith, ME, Schrodi, SJ, Albrecht, RA, Vignuzzi, M, Zuliani-Alvarez, L, Swaney, DL, Eckhardt, M, Wolinsky, SM, White, KM, Hultquist, JF, Kaake, RM, García-Sastre, A, Krogan, NJ

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Abstract P6-06-01: Analyzing the physical and functional protein interaction landscape of breast cancer von Kim, M, Kim, K, Tutuncuoglu, B, Soucheray, M, Swaney, D, Zheng, F, Park, J, O'Leary, P, Coppé, J-P, van 't Veer, L, Ashworth, A, Ideker, T, Krogan, N

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P2.03-31 Chemokine Receptor CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC von Becker, J., Gao, Y., Soucheray, M., Pulido, I., Kikuchi, E., Rodríguez, M., Gandhi, R., Lafuente-Sánchis, A., Aupi, M., Fernandez-Coronado, J. Alcacer, Martín, P., Cremades, A., Galbis-Caravajal, J., Alcacer, J., Christensen, C., Simms, P., Hess, A., Asahina, H., Kahle, M., Al-Shahrour, F., Borgia, J., Lahoz, A., Insa, A., Juan, O., Jänne, P., Wong, K., Carretero, J., Shimamura, T.

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Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors von Akbay, E, Koyama, S, Carretero, J, Altabef, A, Tchaicha, J. H, Christensen, Camilla Laulund, Mikse, O. R, Cherniack, Andrew David, Beauchamp, Ellen Monica, Pugh, T, Wilkerson, M. D, Fecci, P, Butaney, M, Reibel, J. B, Soucheray, M, Cohoon, T. J, Janne, Pasi Antero, Meyerson, Matthew Langer, Hayes, D. N, Shapiro, Geoffrey Ira, Shimamura, T, Sholl, Lynette Marie, Rodig, Scott J, Freeman, Gordon James, Hammerman, Peter Seth, Dranoff, G, Wong, Kwok-Kin

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Evolution of enhanced innate immune evasion by SARS-CoV-2 von Thorne, LG, Bouhaddou, M, Reuschl, AK, Zuliani-Alvarez, L, Polacco, B, Pelin, A, Batra, J, Whelan, MVX, Hosmillo, M, Fossati, A, Ragazzini, R, Jungreis, I, Ummadi, M, Rojc, A, Turner, J, Bischof, ML, Obernier, K, Braberg, H, Soucheray, M, Richards, A, Chen, KH, Harjai, B, Memon, D, Hiatt, J, Rosales, R, McGovern, BL, Jahun, A, Fabius, JM, White, K, Goodfellow, IG, Takeuchi, Y, Bonfanti, P, Shokat, K, Jura, N, Verba, K, Noursadeghi, M, Beltrao, P, Kellis, M, Swaney, DL, García-Sastre, A, Jolly, C, Towers, GJ, Krogan, NJ

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The functional landscape of the human phosphoproteome von Ochoa, David, Jarnuczak, Andrew F., Viéitez, Cristina, Gehre, Maja, Soucheray, Margaret, Mateus, André, Kleefeldt, Askar A., Hill, Anthony, Garcia-Alonso, Luz, Stein, Frank, Krogan, Nevan J., Savitski, Mikhail M., Swaney, Danielle L., Vizcaíno, Juan A., Noh, Kyung-Min, Beltrao, Pedro

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Evolution of enhanced innate immune evasion by SARS-CoV-2 von Thorne, Lucy G., Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Zuliani-Alvarez, Lorena, Polacco, Ben, Pelin, Adrian, Batra, Jyoti, Whelan, Matthew V. X., Hosmillo, Myra, Fossati, Andrea, Ragazzini, Roberta, Jungreis, Irwin, Ummadi, Manisha, Rojc, Ajda, Turner, Jane, Bischof, Marie L., Obernier, Kirsten, Braberg, Hannes, Soucheray, Margaret, Richards, Alicia, Chen, Kuei-Ho, Harjai, Bhavya, Memon, Danish, Hiatt, Joseph, Rosales, Romel, McGovern, Briana L., Jahun, Aminu, Fabius, Jacqueline M., White, Kris, Goodfellow, Ian G., Takeuchi, Yasu, Bonfanti, Paola, Shokat, Kevan, Jura, Natalia, Verba, Klim, Noursadeghi, Mahdad, Beltrao, Pedro, Kellis, Manolis, Swaney, Danielle L., García-Sastre, Adolfo, Jolly, Clare, Towers, Greg J., Krogan, Nevan J.

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The Global Phosphorylation Landscape of SARS-CoV-2 Infection von Bouhaddou, Mehdi, Memon, Danish, Meyer, Bjoern, White, Kris M., Rezelj, Veronica V., Correa Marrero, Miguel, Polacco, Benjamin J., Melnyk, James E., Ulferts, Svenja, Kaake, Robyn M., Batra, Jyoti, Richards, Alicia L., Stevenson, Erica, Gordon, David E., Rojc, Ajda, Obernier, Kirsten, Fabius, Jacqueline M., Soucheray, Margaret, Miorin, Lisa, Moreno, Elena, Koh, Cassandra, Tran, Quang Dinh, Hardy, Alexandra, Robinot, Rémy, Vallet, Thomas, Nilsson-Payant, Benjamin E., Hernandez-Armenta, Claudia, Dunham, Alistair, Weigang, Sebastian, Knerr, Julian, Modak, Maya, Quintero, Diego, Zhou, Yuan, Dugourd, Aurelien, Valdeolivas, Alberto, Patil, Trupti, Li, Qiongyu, Hüttenhain, Ruth, Cakir, Merve, Muralidharan, Monita, Kim, Minkyu, Jang, Gwendolyn, Tutuncuoglu, Beril, Hiatt, Joseph, Guo, Jeffrey Z., Xu, Jiewei, Bouhaddou, Sophia, Mathy, Christopher J.P., Gaulton, Anna, Manners, Emma J., Félix, Eloy, Shi, Ying, Goff, Marisa, Lim, Jean K., McBride, Timothy, O’Neal, Michael C., Cai, Yiming, Chang, Jason C.J., Broadhurst, David J., Klippsten, Saker, De wit, Emmie, Leach, Andrew R., Kortemme, Tanja, Shoichet, Brian, Ott, Melanie, Saez-Rodriguez, Julio, tenOever, Benjamin R., Mullins, R. Dyche, Fischer, Elizabeth R., Kochs, Georg, Grosse, Robert, García-Sastre, Adolfo, Vignuzzi, Marco, Johnson, Jeffery R., Shokat, Kevan M., Swaney, Danielle L., Beltrao, Pedro, Krogan, Nevan J.

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Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer von Brand, Toni M, Hartmann, Stefan, Bhola, Neil E, Li, Hua, Zeng, Yan, O'Keefe, Rachel A, Ranall, Max V, Bandyopadhyay, Sourav, Soucheray, Margaret, Krogan, Nevan J, Kemp, Carolyn, Duvvuri, Umamaheswar, LaVallee, Theresa, Johnson, Daniel E, Ozbun, Michelle A, Bauman, Julie E, Grandis, Jennifer R

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Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer von Straume, Oddbjørn, Shimamura, Takeshi, Lampa, Michael J. G, Carretero, Julian, Øyan, Anne M, Jia, Di, Borgman, Christa L, Soucheray, Margaret, Downing, Sean R, Short, Sarah M, Kang, Soo-Young, Wang, Souming, Chen, Liang, Collett, Karin, Bachmann, Ingeborg, Wong, Kwok-Kin, Shapiro, Geoffrey I, Kalland, Karl Henning, Folkman, Judah, Watnick, Randolph S, Akslen, Lars A, Naumov, George N

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STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment von Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, Wong, Kwok-Kin

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SARS-CoV-2 variants evolve convergent strategies to remodel the host response von Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Polacco, Benjamin J., Thorne, Lucy G., Ummadi, Manisha R., Ye, Chengjin, Rosales, Romel, Pelin, Adrian, Batra, Jyoti, Jang, Gwendolyn M., Xu, Jiewei, Moen, Jack M., Richards, Alicia L., Zhou, Yuan, Harjai, Bhavya, Stevenson, Erica, Rojc, Ajda, Ragazzini, Roberta, Whelan, Matthew V.X., Furnon, Wilhelm, De Lorenzo, Giuditta, Cowton, Vanessa, Syed, Abdullah M., Ciling, Alison, Deutsch, Noa, Pirak, Daniel, Dowgier, Giulia, Mesner, Dejan, Turner, Jane L., McGovern, Briana L., Rodriguez, M. Luis, Leiva-Rebollo, Rocio, Dunham, Alistair S., Zhong, Xiaofang, Eckhardt, Manon, Fossati, Andrea, Liotta, Nicholas F., Kehrer, Thomas, Cupic, Anastasija, Rutkowska, Magdalena, Mena, Ignacio, Aslam, Sadaf, Hoffert, Alyssa, Foussard, Helene, Olwal, Charles Ochieng’, Huang, Weiqing, Zwaka, Thomas, Pham, John, Lyons, Molly, Donohue, Laura, Griffin, Aliesha, Nugent, Rebecca, Holden, Kevin, Deans, Robert, Aviles, Pablo, Lopez-Martin, Jose A., Jimeno, Jose M., Obernier, Kirsten, Fabius, Jacqueline M., Soucheray, Margaret, Hüttenhain, Ruth, Jungreis, Irwin, Kellis, Manolis, Echeverria, Ignacia, Verba, Kliment, Bonfanti, Paola, Beltrao, Pedro, Sharan, Roded, Doudna, Jennifer A., Martinez-Sobrido, Luis, Patel, Arvind H., Palmarini, Massimo, Miorin, Lisa, White, Kris, Swaney, Danielle L., Garcia-Sastre, Adolfo, Jolly, Clare, Zuliani-Alvarez, Lorena, Towers, Greg J., Krogan, Nevan J.

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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors von Akbay, Esra A, Koyama, Shohei, Carretero, Julian, Altabef, Abigail, Tchaicha, Jeremy H, Christensen, Camilla L, Mikse, Oliver R, Cherniack, Andrew D, Beauchamp, Ellen M, Pugh, Trevor J, Wilkerson, Matthew D, Fecci, Peter E, Butaney, Mohit, Reibel, Jacob B, Soucheray, Margaret, Cohoon, Travis J, Janne, Pasi A, Meyerson, Matthew, Hayes, D Neil, Shapiro, Geoffrey I, Shimamura, Takeshi, Sholl, Lynette M, Rodig, Scott J, Freeman, Gordon J, Hammerman, Peter S, Dranoff, Glenn, Wong, Kwok-Kin

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CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells von Rathore, Ujjwal, Haas, Paige, Easwar Kumar, Vigneshwari, Hiatt, Joseph, Haas, Kelsey M, Bouhaddou, Mehdi, Swaney, Danielle L, Stevenson, Erica, Zuliani-Alvarez, Lorena, McGregor, Michael J, Turner-Groth, Autumn, Ochieng' Olwal, Charles, Bediako, Yaw, Braberg, Hannes, Soucheray, Margaret, Ott, Melanie, Eckhardt, Manon, Hultquist, Judd F, Marson, Alexander, Kaake, Robyn M, Krogan, Nevan J

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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis von Kehrer, Thomas, Cupic, Anastasija, Ye, Chengjin, Yildiz, Soner, Bouhaddou, Mehdi, Crossland, Nicholas A., Barrall, Erika A., Cohen, Phillip, Tseng, Anna, Çağatay, Tolga, Rathnasinghe, Raveen, Flores, Daniel, Jangra, Sonia, Alam, Fahmida, Mena, Ignacio, Aslam, Sadaf, Saqi, Anjali, Rutkowska, Magdalena, Ummadi, Manisha R., Pisanelli, Giuseppe, Richardson, R. Blake, Veit, Ethan C., Fabius, Jacqueline M., Soucheray, Margaret, Polacco, Benjamin J., Ak, Baran, Marin, Arturo, Evans, Matthew J., Swaney, Danielle L., Gonzalez-Reiche, Ana S., Sordillo, Emilia M., van Bakel, Harm, Simon, Viviana, Zuliani-Alvarez, Lorena, Fontoura, Beatriz M.A., Rosenberg, Brad R., Krogan, Nevan J., Martinez-Sobrido, Luis, García-Sastre, Adolfo, Miorin, Lisa

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Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets von Haas, Kelsey M., McGregor, Michael J., Bouhaddou, Mehdi, Polacco, Benjamin J., Kim, Eun-Young, Nguyen, Thong T., Newton, Billy W., Urbanowski, Matthew, Kim, Heejin, Williams, Michael A. P., Rezelj, Veronica V., Hardy, Alexandra, Fossati, Andrea, Stevenson, Erica J., Sukerman, Ellie, Kim, Tiffany, Penugonda, Sudhir, Moreno, Elena, Braberg, Hannes, Zhou, Yuan, Metreveli, Giorgi, Harjai, Bhavya, Tummino, Tia A., Melnyk, James E., Soucheray, Margaret, Batra, Jyoti, Pache, Lars, Martin-Sancho, Laura, Carlson-Stevermer, Jared, Jureka, Alexander S., Basler, Christopher F., Shokat, Kevan M., Shoichet, Brian K., Shriver, Leah P., Johnson, Jeffrey R., Shaw, Megan L., Chanda, Sumit K., Roden, Dan M., Carter, Tonia C., Kottyan, Leah C., Chisholm, Rex L., Pacheco, Jennifer A., Smith, Maureen E., Schrodi, Steven J., Albrecht, Randy A., Vignuzzi, Marco, Zuliani-Alvarez, Lorena, Swaney, Danielle L., Eckhardt, Manon, Wolinsky, Steven M., White, Kris M., Hultquist, Judd F., Kaake, Robyn M., García-Sastre, Adolfo, Krogan, Nevan J.

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CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC von Becker, Jeffrey H, Gao, Yandi, Soucheray, Margaret, Pulido, Ines, Kikuchi, Eiki, Rodríguez, María L, Gandhi, Rutu, Lafuente-Sanchis, Aranzazu, Aupí, Miguel, Alcácer Fernández-Coronado, Javier, Martín-Martorell, Paloma, Cremades, Antonio, Galbis-Caravajal, José M, Alcácer, Javier, Christensen, Camilla L, Simms, Patricia, Hess, Ashley, Asahina, Hajime, Kahle, Michael P, Al-Shahrour, Fatima, Borgia, Jeffrey A, Lahoz, Agustín, Insa, Amelia, Juan, Oscar, Jänne, Pasi A, Wong, Kwok-Kin, Carretero, Julian, Shimamura, Takeshi

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Editor's Note: Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer von Brand, Toni M., Hartmann, Stefan, Bhola, Neil E., Li, Hua, Zeng, Yan, O'Keefe, Rachel A., Ranall, Max V., Bandyopadhyay, Sourav, Soucheray, Margaret, Krogan, Nevan J., Kemp, Carolyn, Duvvuri, Umamaheswar, LaVallee, Theresa, Johnson, Daniel E., Ozbun, Michelle A., Bauman, Julie E., Grandis, Jennifer R.

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