Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy von Palmer, Adam C., Sorger, Peter K.

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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs von Hafner, Marc, Niepel, Mario, Chung, Mirra, Sorger, Peter K

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Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method von Lin, Jia-Ren, Fallahi-Sichani, Mohammad, Sorger, Peter K.

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Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks von Lee, Michael J., Ye, Albert S., Gardino, Alexandra K., Heijink, Anne Margriet, Sorger, Peter K., MacBeath, Gavin, Yaffe, Michael B.

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Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models von Fröhlich, Fabian, Sorger, Peter K

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Measuring and Modeling Apoptosis in Single Cells von Spencer, Sabrina L., Sorger, Peter K.

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The Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases von Berginski, Matthew E, Moret, Nienke, Liu, Changchang, Goldfarb, Dennis, Sorger, Peter K, Gomez, Shawn M

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A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis von Gujral, Taranjit S, Chan, Marina, Peshkin, Leonid, Sorger, Peter K, Kirschner, Marc W, MacBeath, Gavin

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Surviving apoptosis: life–death signaling in single cells von Flusberg, Deborah A, Sorger, Peter K

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Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes von Lin, Jia-Ren, Izar, Benjamin, Wang, Shu, Yapp, Clarence, Mei, Shaolin, Shah, Parin M, Santagata, Sandro, Sorger, Peter K

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity von Ringel, Alison E., Drijvers, Jefte M., Baker, Gregory J., Catozzi, Alessia, García-Cañaveras, Juan C., Gassaway, Brandon M., Miller, Brian C., Juneja, Vikram R., Nguyen, Thao H., Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T., LaFleur, Martin W., Trombley, Justin D., Jacobson, Connor A., Maliga, Zoltan, Gygi, Steven P., Sorger, Peter K., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.

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Machine learning identifies candidates for drug repurposing in Alzheimer’s disease von Rodriguez, Steve, Hug, Clemens, Todorov, Petar, Moret, Nienke, Boswell, Sarah A., Evans, Kyle, Zhou, George, Johnson, Nathan T., Hyman, Bradley T., Sorger, Peter K., Albers, Mark W., Sokolov, Artem

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A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity von Palmer, Adam C, Chidley, Christopher, Sorger, Peter K

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Drug independence and the curability of cancer by combination chemotherapy von Pomeroy, Amy E, Schmidt, Emmett V, Sorger, Peter K, Palmer, Adam C

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Metrics other than potency reveal systematic variation in responses to cancer drugs von Fallahi-Sichani, Mohammad, Honarnejad, Saman, Heiser, Laura M, Gray, Joe W, Sorger, Peter K

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Fundamental trade-offs between information flow in single cells and cellular populations von Suderman, Ryan, Bachman, John A., Smith, Adam, Sorger, Peter K., Deeds, Eric J.

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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis von Spencer, Sabrina L, Gaudet, Suzanne, Albeck, John G, Burke, John M, Sorger, Peter K

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Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity von Hafner, Marc, Mills, Caitlin E., Subramanian, Kartik, Chen, Chen, Chung, Mirra, Boswell, Sarah A., Everley, Robert A., Liu, Changchang, Walmsley, Charlotte S., Juric, Dejan, Sorger, Peter K.

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Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer von Färkkilä, Anniina, Gulhan, Doga C., Casado, Julia, Jacobson, Connor A., Nguyen, Huy, Kochupurakkal, Bose, Maliga, Zoltan, Yapp, Clarence, Chen, Yu-An, Schapiro, Denis, Zhou, Yinghui, Graham, Julie R., Dezube, Bruce J., Munster, Pamela, Santagata, Sandro, Garcia, Elizabeth, Rodig, Scott, Lako, Ana, Chowdhury, Dipanjan, Shapiro, Geoffrey I., Matulonis, Ursula A., Park, Peter J., Hautaniemi, Sampsa, Sorger, Peter K., Swisher, Elizabeth M., D’Andrea, Alan D., Konstantinopoulos, Panagiotis A.

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Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques von Aid, Malika, Busman-Sahay, Kathleen, Vidal, Samuel J., Maliga, Zoltan, Bondoc, Stephen, Starke, Carly, Terry, Margaret, Jacobson, Connor A., Wrijil, Linda, Ducat, Sarah, Brook, Olga R., Miller, Andrew D., Porto, Maciel, Pellegrini, Kathryn L., Pino, Maria, Hoang, Timothy N., Chandrashekar, Abishek, Patel, Shivani, Stephenson, Kathryn, Bosinger, Steven E., Andersen, Hanne, Lewis, Mark G., Hecht, Jonathan L., Sorger, Peter K., Martinot, Amanda J., Estes, Jacob D., Barouch, Dan H.

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