Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease von Comery, Thomas A, Martone, Robert L, Aschmies, Suzan, Atchison, Kevin P, Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F, Pangalos, Menelas N, Sonnenberg-Reines, June, Jacobsen, J Steven, Marquis, Karen L

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Selective Aggregation of Endogenous β‐Amyloid Peptide and Soluble Amyloid Precursor Protein in Cerebrospinal Fluid by Zinc von Brown, Abraham M., Tummolo, Donna M., Rhodes, Kenneth J., Hofmann, John R., Jacobsen, J. Steven, Sonnenberg‐Reines, June

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Evaluation of Cathepsins D and G and EC 3.4.24.15 as Candidate β‐Secretase Proteases Using Peptide and Amyloid Precursor Protein Substrates von Brown, Abraham M., Tummolo, Donna M., Spruyt, Michael A., Jacobsen, J. Steven, Sonnenberg‐Reines, June

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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease von Martone, Robert L, Zhou, Hua, Atchison, Kevin, Comery, Thomas, Xu, Jane Z, Huang, Xinyi, Gong, Xioahai, Jin, Mei, Kreft, Anthony, Harrison, Boyd, Mayer, Scott C, Aschmies, Suzan, Gonzales, Cathleen, Zaleska, Margaret M, Riddell, David R, Wagner, Erik, Lu, Peimin, Sun, Shaiu-Ching, Sonnenberg-Reines, June, Oganesian, Aram, Adkins, Karissa, Leach, Michael W, Clarke, David W, Huryn, Donna, Abou-Gharbia, Magid, Magolda, Ronald, Bard, Jonathan, Frick, Glen, Raje, Sangeeta, Forlow, S Bradley, Balliet, Carrie, Burczynski, Michael E, Reinhart, Peter H, Wan, Hong I, Pangalos, Menelas N, Jacobsen, J Steven

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Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors von Gundersen, Eric, Fan, Kristi, Haas, Kimberly, Huryn, Donna, Steven Jacobsen, J., Kreft, Anthony, Martone, Robert, Mayer, Scott, Sonnenberg-Reines, June, Sun, Shaiu-Ching, Zhou, Hua

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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease von Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven

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Brain and plasma exposure profiling in early drug discovery using cassette administration and fast liquid chromatography-tandem mass spectrometry von Zhang, Mei-Yi, Kerns, Edward, McConnell, Oliver, Sonnenberg-Reines, June, Zaleska, Margaret M., Steven Jacobsen, J., Butera, John, Kreft, Anthony

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The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment von JACOBSEN, J. S, SPRUYT, M. A, BROWN, A. M, SAHASRABUDHE, S. R, BLUME, A. J, VITEK, M. P, MUENKEL, H. A, SONNENBERG-REINES, J

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Discovery of a novel series of Notch-sparing γ-secretase inhibitors von Kreft, Anthony, Harrison, Boyd, Aschmies, Suzan, Atchison, Kevin, Casebier, David, Cole, Derek C., Diamantidis, George, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Lundquist, Joseph, Mann, Charles, Martone, Robert, Moore, William, Oganesian, Aram, Porte, Alex, Riddell, Dave R., Sonnenberg-Reines, June, Stock, Joseph R., Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Steven Jacobsen, J.

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( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor von Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven

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Synthesis and structure–activity relationship of a novel series of heterocyclic sulfonamide γ-secretase inhibitors von Pu, Jun, Kreft, Anthony F., Aschmies, Suzan H., Atchison, Kevin P., Berkowitz, Joshua, Caggiano, Thomas J., Chlenov, Micheal, Diamantidis, George, Harrison, Boyd L., Hu, Yun, Huryn, Donna, Steven Jacobsen, J., Jin, Mei, Lipinski, Kerri, Lu, Peimin, Martone, Robert L., Morris, Koi, Sonnenberg-Reines, June, Riddell, Dave R., Sabalski, Joan, Sun, Shaiu-Ching, Wagner, Erik, Wang, Yiqun, Xu, Zheng, Zhou, Hua, Resnick, Lynn

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Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease von Robert L. Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z. Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott C. Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret M. Zaleska, David R. Riddell, Erik Wagner, Peimin Lu, Shaiu-Ching Sun, June Sonnenberg-Reines, Aram Oganesian, Karissa Adkins, Michael W. Leach, David W. Clarke, Donna Huryn, Magid Abou-Gharbia, Ronald Magolda, Jonathan Bard, Glen Frick, Sangeeta Raje, S. Bradley Forlow, Carrie Balliet, Michael E. Burczynski, Peter H. Reinhart, Hong I. Wan, Menelas N. Pangalos, J. Steven Jacobsen

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P2-302: GSI-953 is a potent APP-selective gamma-secretase inhibitor for the treatment of Alzheimer's disease von Jacobsen, Steven, Comery, Thomas, Aschmies, Suzan, Zhou, Hua, Jin, Mei, Atchison, Kevin, Xu, Jane, Wagner, Erik, Sonnenberg-Reines, June, Kreft, Anthony, Sun, Roy, Liu, Peimin, Gong, Xiaohai, Zaleska, Margaret, Adkins, Karissa, Oganesian, Aram, Folletti, Maximillian, Wan, Hong, Mayer, Scott, Hoke, Molly, Reinhart, Peter, Harrison, Boyd, Magolda, Ron, Pangalos, Menelas, Martone, Robert

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P4-244: Discovery of a novel series of notch-sparing γ-secretase inhibitors von Harrison, Boyd L., Kreft, Anthony, Aschmies, Susan, Atchison, Kevin, Cole, Derek, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Mann, Charles, Martone, Robert, Moore, William, Porte, Alex, Riddell, David, Sonnenberg-Reines, June, Stock, Joseph, Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Jacobsen, Steven

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Biotinylated and Cysteine-Modified Peptides as Useful Reagents for Studying the Inhibition of Cathepsin G von Brown, A.M., George, S.M., Blume, A.J., Dushin, R.G., Jacobsen, J.S., Sonnenbergreines, J.

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Characterization of endogenous APP processing in a cell-free system von Brown, Abraham M., Potempska, Anna, Tummolo, Donna, Spruyt, Michael A., Jacobsen, J. Steven, Sonnenberg-Reines, June

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Acute {gamma}-Secretase Inhibition Improves Contextual Fear Conditioning in the Tg2576 Mouse Model of Alzheimer's Disease von Comery, Thomas A, Martone, Robert L, Aschmies, Suzan, Atchison, Kevin P, Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F, Pangalos, Menelas N, Sonnenberg-Reines, June, Jacobsen, J. Steven, Marquis, Karen L

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