Navigating the kinome von Hajduk, Philip J, Metz, James T, Johnson, Eric F, Soni, Niru B, Merta, Philip J, Kifle, Lemma

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1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinas... von Chen, Zehan, Gopalakrishnan, Sujatha M, Bui, Mai-Ha, Soni, Niru B, Warrior, Usha, Johnson, Eric F, Donnelly, Jennifer B, Glaser, Keith B

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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor von XUESONG LIU, YAN SHI, XU, Allison J, LAYER, Ramesh, HARLAN, John E, SOLOMON, Larry R, DONAWHO, Cherrie K, PENNING, Thomas D, JOHNSON, Eric F, SHOEMAKER, Alexander R, MAAG, David X, PALMA, Joann P, PATTERSON, Melanie J, ELLIS, Paul A, SURBER, Bruce W, READY, Damien B, SONI, Niru B, LADROR, Uri S

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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors von Dai, Yujia, Hartandi, Kresna, Soni, Niru B., Pease, Lori J., Reuter, David R., Olson, Amanda M., Osterling, Donald J., Doktor, Stella Z., Albert, Daniel H., Bouska, Jennifer J., Glaser, Keith B., Marcotte, Patrick A., Stewart, Kent D., Davidsen, Steven K., Michaelides, Michael R.

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Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605 von Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, Grudzien, Meagan M, Soni, Niru B, Johnson, Eric F, Sheppard, George S, Donawho, Cherrie, Buchanan, Fritz G, Davidsen, Steven K, Bell, Randy L, Wang, Jieyi

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Discovery of N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N‘-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-Aminoindazole-Based Orally Active Multitargeted Receptor Tyrosine Kinase Inhibito... von Dai, Yujia, Hartandi, Kresna, Ji, Zhiqin, Ahmed, Asma A, Albert, Daniel H, Bauch, Joy L, Bouska, Jennifer J, Bousquet, Peter F, Cunha, George A, Glaser, Keith B, Harris, Christopher M, Hickman, Dean, Guo, Jun, Li, Junling, Marcotte, Patrick A, Marsh, Kennan C, Moskey, Maria D, Martin, Ruth L, Olson, Amanda M, Osterling, Donald J, Pease, Lori J, Soni, Niru B, Stewart, Kent D, Stoll, Vincent S, Tapang, Paul, Reuter, David R, Davidsen, Steven K, Michaelides, Michael R

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Novel Antibacterial Class von DANDLIKER, Peter J, PRATT, Steve D, CHOVAN, Linda E, HICKMAN, Robert K, DALY, Melissa M, KAKAVAS, Stephan, PING ZHONG, ZHENSHENG CAO, DAVID, Caroline A, XIAOLING XUEI, LERNER, Claude G, SONI, Niru B, NILIUS, Angela M, MAI BUI, SHEN, Linus L, YINGNA CAI, MERTA, Philip J, SAIKI, Anne Y. C, BEUTEL, Bruce A, BLACK-SCHAEFER, Candace, XIAOAN RUAN, TOWNE, Danli L, CLARK, Richard F, ENGLUND, Erika E, WAGNER, Rolf, WEITZBERG, Moshe

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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling von Tong, Yunsong, Stewart, Kent D., Thomas, Sheela, Przytulinska, Magdalena, Johnson, Eric F., Klinghofer, Vered, Leverson, Joel, McCall, Owen, Soni, Niru B., Luo, Yan, Lin, Nan-horng, Sowin, Thomas J., Giranda, Vincent L., Penning, Thomas D.

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Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents von Beebe, Xenia, Nilius, Angela M., Merta, Philip J., Soni, Niru B., Bui, Mai H., Wagner, Rolf, Beutel, Bruce A.

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7-Aminopyrazolo[1,5-a]pyrimidines as Potent Multitargeted Receptor Tyrosine Kinase Inhibitors von Frey, Robin R, Curtin, Michael L, Albert, Daniel H, Glaser, Keith B, Pease, Lori J, Soni, Niru B, Bouska, Jennifer J, Reuter, David, Stewart, Kent D, Marcotte, Patrick, Bukofzer, Gail, Li, Junling, Davidsen, Steven K, Michaelides, Michael R

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Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families von Curtin, Michael L., Frey, Robin R., Heyman, H. Robin, Soni, Niru B., Marcotte, Patrick A., Pease, Lori J., Glaser, Keith B., Magoc, Terrance J., Tapang, Paul, Albert, Daniel H., Osterling, Donald J., Olson, Amanda M., Bouska, Jennifer J., Guan, Zhiwen, Preusser, Lee C., Polakowski, James S., Stewart, Kent D., Tse, Chris, Davidsen, Steven K., Michaelides, Michael R.

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Thienopyridine urea inhibitors of KDR kinase von Heyman, H. Robin, Frey, Robin R., Bousquet, Peter F., Cunha, George A., Moskey, Maria D., Ahmed, Asma A., Soni, Niru B., Marcotte, Patrick A., Pease, Lori J., Glaser, Keith B., Yates, Melinda, Bouska, Jennifer J., Albert, Daniel H., Black-Schaefer, Candace L., Dandliker, Peter J., Stewart, Kent D., Rafferty, Paul, Davidsen, Steven K., Michaelides, Michael R., Curtin, Michael L.

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Novel Antibacterial Class:  A Series of Tetracyclic Derivatives von Hinman, Mira M, Rosenberg, Teresa A, Balli, Darlene, Black-Schaefer, Candace, Chovan, Linda E, Kalvin, Douglas, Merta, Philip J, Nilius, Angela M, Pratt, Steve D, Soni, Niru B, Wagenaar, Frank L, Weitzberg, Moshe, Wagner, Rolf, Beutel, Bruce A

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The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity von Bromberg, Kenneth D, Mitchell, Taylor R H, Upadhyay, Anup K, Jakob, Clarissa G, Jhala, Manisha A, Comess, Kenneth M, Lasko, Loren M, Li, Conglei, Tuzon, Creighton T, Dai, Yujia, Li, Fengling, Eram, Mohammad S, Nuber, Alexander, Soni, Niru B, Manaves, Vlasios, Algire, Mikkel A, Sweis, Ramzi F, Torrent, Maricel, Schotta, Gunnar, Sun, Chaohong, Michaelides, Michael R, Shoemaker, Alex R, Arrowsmith, Cheryl H, Brown, Peter J, Santhakumar, Vijayaratnam, Martin, Alberto, Rice, Judd C, Chiang, Gary G, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Pappano, William N

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Antimicrobial susceptibility and molecular characterization of community-acquired methicillin-resistant Staphylococcus aureus von Almer, Laurel S, Shortridge, Virginia D, Nilius, Angela M, Beyer, Jill M, Soni, Niru B, Bui, Mai H, Stone, Gregory G, Flamm, Robert K

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An Unusual Intramolecular Hetero-Diels−Alder Cycloaddition von Stoner, Eric J, Allen, Michael S, Christesen, Alan C, Henry, Rodger F, Hollis, L. Steven, Keyes, Robert, Marsden, Ian, Rehm, Tamara C, Shiroor, Sandeep G, Soni, Niru B, Stewart, Kent D

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A Strategy for Discovery of Novel Broad-Spectrum Antibacterials Using a High-Throughput Streptococcus pneumoniae Transcription/Translation Screen von Pratt, Steven D., David, Caroline A., Black-Schaefer, Candace, Dandliker, Peter J., Xuei, Xiaoling, Warrior, Usha, Burns, David J., Zhong, Ping, Cao, Zhensheng, Saiki, Anne Y.C., Lerner, Claude G., Chovan, Linda E., Soni, Niru B., Nilius, Angela M., Wagenaar, Frank L., Merta, Philip J., Traphagen, Linda M., Beutel, Bruce A.

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Abstract 5532: Discovery of A-366, a novel small molecule inhibitor that uncovers an unappreciated role for G9a/GLP in the epigenetics of leukemia von Guo, Jun, Pliushchev, Marina, He, Yupeng, Ferguson, Debra, Jagadeeswaran, Sujatha, Petros, Andrew, Sun, Chaohong, Soni, Niru B., Shaw, Bailin, Korepanova, Alla, Maag, David, Sweis, Ramzi, Buchanan, Fritz G., Michaelides, Michael, Shoemaker, Alex, Tse, Chris, Chiang, Gary G., Pappano, William N.

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1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2) von Chen, Zehan, Gopalakrishnan, Sujatha M., Bui, Mai-Ha, Soni, Niru B., Warrior, Usha, Johnson, Eric F., Donnelly, Jennifer B., Glaser, Keith B.

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Abstract C202: Discovery and initial characterization of the clinical compound ABT-348, a potent inhibitor of the VEGF, PDGF, and Aurora kinase families von Curtin, Michael L., Heyman, Robin, Frey, Robin R., Soni, Niru B., Marcotte, Patick A., Pease, Lori J., Glaser, Keith B., Magoc, Terrance J., Tapang, Paul, Albert, Daniel H., Osterling, Donald J., Olson, Amanda M., Bouska, Jennifer J., Guan, Zhiwen, Martin, Ruth L., Stewart, Kent D., Tse, Chris, Davidsen, Steven K., Michaelides, Michael R.

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