Exploring Ligand Stability in Protein Crystal Structures Using Binding Pose Metadynamics von Fusani, Lucia, Palmer, David S, Somers, Don O, Wall, Ian D

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Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor von Measom, Nicholas D, Down, Kenneth D, Hirst, David J, Jamieson, Craig, Manas, Eric S, Patel, Vipulkumar K, Somers, Don O

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Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode von Kranz, Michael, Wall, Michael, Evans, Brian, Miah, Afjal, Ballantine, Stuart, Delves, Chris, Dombroski, Brian, Gross, Jeffrey, Schneck, Jessica, Villa, James P., Neu, Margarete, Somers, Don O.

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A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors von Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.

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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors von Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon

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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) von Woolford, Alison J.-A, Day, Philip J, Bénéton, Véronique, Berdini, Valerio, Coyle, Joseph E, Dudit, Yann, Grondin, Pascal, Huet, Pascal, Lee, Lydia Y. W, Manas, Eric S, McMenamin, Rachel L, Murray, Christopher W, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna J, Sang, Yingxia, Somers, Don O, Trottet, Lionel, Wan, Zehong, Zhang, Xiaomin

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Covalent targeting of non-cysteine residues in PI4KIIIβ von Cosgrove, Brett, Grant, Emma K, Bertrand, Sophie, Down, Kenneth D, Somers, Don O, Evans, John, Tomkinson, Nicholas C. O, Barker, Michael D

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Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors von Garton, Neil S., Barker, Michael D., Davis, Rob P., Douault, Clement, Hooper-Greenhill, Edward, Jones, Emma, Lewis, Huw D., Liddle, John, Lugo, Dave, McCleary, Scott, Preston, Alex G.S., Ramirez-Molina, Cesar, Neu, Margarete, Shipley, Tracy J., Somers, Don O., Watson, Robert J., Wilson, David M.

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Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors von Hamblin, J. Nicole, Angell, Tony D.R., Ballantine, Stuart P., Cook, Caroline M., Cooper, Anthony W.J., Dawson, John, Delves, Christopher J., Jones, Paul S., Lindvall, Mika, Lucas, Fiona S., Mitchell, Charlotte J., Neu, Margarete Y., Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

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Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity von Angell, Richard, Aston, Nicola M., Bamborough, Paul, Buckton, Jacky B., Cockerill, Stuart, deBoeck, Suzanne J., Edwards, Chris D., Holmes, Duncan S., Jones, Katherine L., Laine, Dramane I., Patel, Shila, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L.

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Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration von Woodrow, Michael D., Ballantine, Stuart P., Barker, Michael D., Clarke, Beth J., Dawson, John, Dean, Tony W., Delves, Christopher J., Evans, Brian, Gough, Sharon L., Guntrip, Steven B., Holman, Stuart, Holmes, Duncan S., Kranz, Michael, Lindvaal, Mika K., Lucas, Fiona S., Neu, Margarete, Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Ward, Peter, Wiseman, Joanne O.

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Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes von Angell, Richard M., Angell, Tony D., Bamborough, Paul, Bamford, Mark J., Chung, Chun-wa, Cockerill, Stuart G., Flack, Stephen S., Jones, Katherine L., Laine, Dramane I., Longstaff, Timothy, Ludbrook, Steve, Pearson, Rosannah, Smith, Kathryn J., Smee, Penny A., Somers, Don O., Walker, Ann L.

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Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA 2 Inhibitor von Measom, Nicholas D, Down, Kenneth D, Hirst, David J, Jamieson, Craig, Manas, Eric S, Patel, Vipulkumar K, Somers, Don O

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Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR von Mitchell, Charlotte J., Ballantine, Stuart P., Coe, Diane M., Cook, Caroline M., Delves, Christopher J., Dowle, Mike D., Edlin, Chris D., Hamblin, J. Nicole, Holman, Stuart, Johnson, Martin R., Jones, Paul S., Keeling, Sue E., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Solanke, Yemisi E., Somers, Don O., Trivedi, Naimisha A., Wiseman, Joanne O.

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Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration von Lunniss, Christopher J., Cooper, Anthony W.J., Eldred, Colin D., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Preston, Alex G.S., Ranshaw, Lisa E., Redgrave, Alison J., Ed Robinson, J., Shipley, Tracy J., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.

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Kinase array design, back to front: Biaryl amides von Baldwin, Ian, Bamborough, Paul, Haslam, Claudine G., Hunjan, Suchete S., Longstaff, Tim, Mooney, Christopher J., Patel, Shila, Quinn, Jo, Somers, Don O.

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Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR von Angell, Richard M., Angell, Tony D., Bamborough, Paul, Brown, David, Brown, Murray, Buckton, Jacky B., Cockerill, Stuart G., Edwards, Chris D., Jones, Katherine L., Longstaff, Tim, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L., Willson, Malcolm

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A knowledge-based, structural-aided discovery of a novel class of 2-phe-nylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors von Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.

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Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration von Esnouf, Robert M., Ren, Jingshan, Garman, Elspeth F., Somers, Don O'N., Ross, Carl K., Jones, E. Yvonne, Stammers, David K., Stuart, David I.

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ARTICULOS VERTIBLES DE MATERIALES PLASTICOS NORMALMENTE PEGAJOSOS Y PROCEDIMIENTO PARA SU PREPARACION von SOMERS,MARC STACEY, HOOKER, STEPHEN RUSSELL, COE, STEPHEN WAYNE, JARRELL, DON WILLES, MCCOSKEY,STEVEN LOUIS

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