Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis von Anderson, Daniel J., Le Moigne, Ronan, Djakovic, Stevan, Kumar, Brajesh, Rice, Julie, Wong, Steve, Wang, Jinhai, Yao, Bing, Valle, Eduardo, Kiss von Soly, Szerenke, Madriaga, Antonett, Soriano, Ferdie, Menon, Mary-Kamala, Wu, Zhi Yong, Kampmann, Martin, Chen, Yuwen, Weissman, Jonathan S., Aftab, Blake T., Yakes, F. Michael, Shawver, Laura, Zhou, Han-Jie, Wustrow, David, Rolfe, Mark

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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction von Simonetta, Kyle R., Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E., Padovani, Chris, Lou, Yan, Cummins, Thomas J., Yung, Stephanie L., von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A., Bence, Neil F., Barsanti, Paul A., Saha, Anjanabha

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Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083) von Zhou, Han-Jie, Wang, Jinhai, Yao, Bing, Wong, Steve, Djakovic, Stevan, Kumar, Brajesh, Rice, Julie, Valle, Eduardo, Soriano, Ferdie, Menon, Mary-Kamala, Madriaga, Antonett, Kiss von Soly, Szerenke, Kumar, Abhinav, Parlati, Francesco, Yakes, F. Michael, Shawver, Laura, Le Moigne, Ronan, Anderson, Daniel J, Rolfe, Mark, Wustrow, David

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Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signal... von Hill, Rachel A., Klug, Maren, Kiss Von Soly, Szerenke, Binder, Michele D., Hannan, Anthony J., van den Buuse, Maarten

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The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma von Le Moigne, Ronan, Aftab, Blake T, Djakovic, Stevan, Dhimolea, Eugen, Valle, Eduardo, Murnane, Megan, King, Emily M, Soriano, Ferdie, Menon, Mary-Kamala, Wu, Zhi Yong, Wong, Stephen T, Lee, Grace J, Yao, Bing, Wiita, Arun P, Lam, Christine, Rice, Julie, Wang, Jinhai, Chesi, Marta, Bergsagel, P Leif, Kraus, Marianne, Driessen, Christoph, Kiss von Soly, Szerenke, Yakes, F Michael, Wustrow, David, Shawver, Laura, Zhou, Han-Jie, Martin, 3rd, Thomas G, Wolf, Jeffrey L, Mitsiades, Constantine S, Anderson, Daniel J, Rolfe, Mark

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Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain von Hill, Rachel A., Kiss Von Soly, Szerenke, Ratnayake, Udani, Klug, Maren, Binder, Michele D., Hannan, Anthony J., van den Buuse, Maarten

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Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target von Gosling, Jennifa, Rountree, Ryan, Taherbhoy, Asad, Wang, Chenbo, Cummins, Thomas, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Cardozo, Mario, Karim, Christopher, Tan, May, Juan, Joseph, Tenn-McClellan, Austin, Soly, Szerenke Kiss von, Sheung, Julie, Boyle, Kathleen, Dhamnaskar, Ketki, Kurylo, Katherine, Bruffey, Jilliane, McKinnell, Jennifer, Karr, Dane, Christianson, Andria, Vries, Anne-Renee Van Der Vuurst de, Sivakumar, Pallavur, Gallop, Mark, Barsanti, Paul A., Saha, Anjanabha, Bence, Neil F., Zapf, Christoph W.

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Abstract DDT02-01: Inhibition of the AAA-ATPase p97 with the first in class inhibitor CB-5083 as a novel approach to treat cancer von Anderson, Daniel J., Le Moigne, Ronan, Djakovic, Stevan, Kumar, Brajesh, Rice, Julie, Wong, Steve, Wang, Jinhai, Yao, Bing, Valle, Eduardo, Menon, MK, Kiss von Soly, Szerenke, Madriaga, Antonett, Sorlano, Ferdie, Longhi, Mike, Cesano, Alessandra, Zhou, Han-Jie, Wustrow, David, Rolfe, Mark

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Pre-Clinical Activity of the Novel, First-in-Class p97 Inhibitor, CB-5083, in Multiple Myeloma von Aftab, Blake T., Anderson, Daniel J, Le Moigne, Ronan, Djakovic, Stevan, Dhimolea, Eugen, Murnane, Megan, King, Emily, Rice, Julie, Wong, Steve, Kumar, Brajesh, Valle, Eduardo, Menon, Mary-Kamala, Kiss von Soly, Szerenke, Wang, Jinhai, Yao, Bing, Soriano, Ferdie, Kampmann, Martin, Alcost-Alvear, Diego, Chesi, Marta, Bergsagel, Leif, Yakes, F. Michael, Zhou, Han-Jie, Wustrow, David, Martin, Thomas G., Wolf, Jeffrey L., Mitsiades, Constantine S., Rolfe, Mark

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Abstract 951: CB-5083 is a novel first in class p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models von Moigne, Ronan L., Wong, Steve, Soriano, Ferdie, Valle, Eduardo, Anderson, Daniel J., Djakovic, Stevan, Menon, Mary-Kamala, Yao, Bing, Rice, Julie, Wang, Jinhai, Soly, Szerenke Kiss Von, Kumar, Brajesh, Chesi, Marta, Bergsagel, P. Leif, Zhou, Han-Jie, Wustrow, David, Rolfe, Mark, Yakes, F. Michael

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Abstract C188: Novel small molecule inhibitors of p97 disrupt cellular protein homeostasis and demonstrate anti-tumor activity in solid and hematological models von Djakovic, Stevan N., Anderson, Daniel J., Kiss von Soly, Szerenke, Le Moigne, Ronan, Rice, Julie, Rolfe, Mark, Soriano, Ferdie, Valle, Eduardo, Wang, Jinhai, Wong, Steve, Wustrow, David, Yakes, F. Michael, Yao, Bing, Zhou, Han-Jie

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