Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance von Maulloo, Chitavi D., Cao, Shijie, Watkins, Elyse A., Raczy, Michal M., Solanki, Ani. S., Nguyen, Mindy, Reda, Joseph W., Shim, Ha-Na, Wilson, D. Scott, Swartz, Melody A., Hubbell, Jeffrey A.

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“Dual Disease” TgAD/GSS mice exhibit enhanced Alzheimer’s disease pathology and reveal PrPC-dependent secretion of Aβ von Qin, Kefeng, Zhao, Lili, Gregory, Crystal, Solanki, Ani, Mastrianni, James A.

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Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease von Cortes, Constanza J, Qin, Kefeng, Cook, Julie, Solanki, Ani, Mastrianni, James A

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Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin‐10 in Murine Models von Yuba, Eiji, Budina, Erica, Katsumata, Kiyomitsu, Ishihara, Ako, Mansurov, Aslan, Alpar, Aaron T., Watkins, Elyse A., Hosseinchi, Peyman, Reda, Joseph W., Lauterbach, Abigail L., Nguyen, Mindy, Solanki, Ani, Kageyama, Takahiro, Swartz, Melody A., Ishihara, Jun, Hubbell, Jeffrey A.

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Abstract P3140: Targeting Of Kinin B1r/il-6 Signaling Prevents Microvascular Leakage And Mitochondrial Dysfunction In Sepsis Induced Heart Failure von Pan, Kaichao, Zhang, Qin, Ullah, Karim, Solanki, Ani, Sitikov, Allbert, Liao, James K, Wu, Rongxue

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Blocking antibodies against integrin-α3, -αM, and -αMβ2 de-differentiate myofibroblasts, and improve lung fibrosis and kidney fibrosis von White, Michael J. V., Ozkan, Melis, Gomez-Medellin, Jorge Emiliano, Rączy, Michal M., Koss, Kyle M., Solanki, Ani, Zhang, Zheng Jenny, Alpar, Aaron T., Naved, Bilal A., Wertheim, Jason, Hubbell, Jeffrey A.

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Anle138b prevents PrP plaque accumulation in Tg(PrP-A116V) mice but does not mitigate clinical disease von Qin, Kefeng, Zhao, Lili, Solanki, Ani, Busch, Crystal, Mastrianni, James

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Injectable butyrate-prodrug micelles induce long-acting immune modulation and prevent autoimmune arthritis in mice von Cao, Shijie, Budina, Erica, Wang, Ruyi, Sabados, Matthew, Mukherjee, Anish, Solanki, Ani, Nguyen, Mindy, Hultgren, Kevin, Dhar, Arjun, Hubbell, Jeffrey A.

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Reversal of Lactate and PD-1-mediated Macrophage Immunosuppression Controls Growth of PTEN/p53-deficient Prostate Cancer von Chaudagar, Kiranj, Hieromnimon, Hanna M, Khurana, Rimpi, Labadie, Brian, Hirz, Taghreed, Mei, Shenglin, Hasan, Raisa, Shafran, Jordan, Kelley, Anne, Apostolov, Eva, Al-Eryani, Ghamdan, Harvey, Kate, Rameshbabu, Srikrishnan, Loyd, Mayme, Bynoe, Kaela, Drovetsky, Catherine, Solanki, Ani, Markiewicz, Erica, Zamora, Marta, Fan, Xiaobing, Schürer, Stephan, Swarbrick, Alex, Sykes, David B, Patnaik, Akash

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Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis von Chaudagar, Kiranj, Hieromnimon, Hanna M, Kelley, Anne, Labadie, Brian, Shafran, Jordan, Rameshbabu, Srikrishnan, Drovetsky, Catherine, Bynoe, Kaela, Solanki, Ani, Markiewicz, Erica, Fan, Xiaobing, Loda, Massimo, Patnaik, Akash

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Abstract 330: Kinin B1r Inhibitor Prevents Sepsis-induced Cardiac Dysfunction And Promotes Survival In Mice von Pan, Kaichao, Zhang, Qin, Fang, Ocean, Nguyen, Tu, Solanki, Ani, Nadella, Anish, Piao, Lin, Sharp, Willard, Liao, James K, Wu, Rongxue

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Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis von Ishihara, Ako, Ishihara, Jun, Watkins, Elyse A., Tremain, Andrew C., Nguyen, Mindy, Solanki, Ani, Katsumata, Kiyomitsu, Mansurov, Aslan, Budina, Erica, Alpar, Aaron T., Hosseinchi, Peyman, Maillat, Lea, Reda, Joseph W., Kageyama, Takahiro, Swartz, Melody A., Yuba, Eiji, Hubbell, Jeffrey A.

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Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant von Gray, Laura T., Raczy, Michal M., Briquez, Priscilla S., Marchell, Tiffany M., Alpar, Aaron T., Wallace, Rachel P., Volpatti, Lisa R., Sasso, Maria Stella, Cao, Shijie, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Watkins, Elyse A., Solanki, Ani, Mitrousis, Nikolaos, Reda, Joseph W., Yu, Shann S., Tremain, Andrew C., Wang, Ruyi, Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Manicassamy, Balaji, Randall, Glenn, Wilson, D. Scott, Kwissa, Marcin, Swartz, Melody A., Hubbell, Jeffrey A.

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Therapeutic use of α2-antiplasmin as an antifibrinolytic and hemostatic agent in surgery and regenerative medicine von Liu, Jialu, Solanki, Ani, White, Michael J. V., Hubbell, Jeffrey A., Briquez, Priscilla S.

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Immune Potentiation of PLGA Controlled-Release Vaccines for Improved Immunological Outcomes von Cassaidy, Britteny J., Moser, Brittany A., Solanki, Ani, Chen, Qing, Shen, Jingjing, Gotsis, Kristen, Lockhart, Zoe, Rutledge, Nakisha, Rosenberger, Matthew G., Dong, Yixiao, Davis, Delaney, Esser- Kahn, Aaron P.

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Temporal Control of Trained Immunity via Encapsulated Release of β‐Glucan Improves Therapeutic Applications von Ajit, Jainu, Cassaidy, Britteny, Tang, Sophia, Solanki, Ani, Chen, Qing, Shen, Jingjing, Esser Kahn, Aaron P.

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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker von Mansurov, Aslan, Hosseinchi, Peyman, Chang, Kevin, Lauterbach, Abigail L., Gray, Laura T., Alpar, Aaron T., Budina, Erica, Slezak, Anna J., Kang, Seounghun, Cao, Shijie, Solanki, Ani, Gomes, Suzana, Williford, John-Michael, Swartz, Melody A., Mendoza, Juan L., Ishihara, Jun, Hubbell, Jeffrey A.

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The integrated stress response in hypoxia-induced diffuse white matter injury von Clayton, Benjamin Ll, Huang, Aaron, Kunjamma, Rejani B, Solanki, Ani, Popko, Brian

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Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics von Wallace, Rachel P, Refvik, Kirsten C, Antane, Jennifer T, Brünggel, Kym, Tremain, Andrew C, Raczy, Michal R, Alpar, Aaron T, Nguyen, Mindy, Solanki, Ani, Slezak, Anna J, Watkins, Elyse A, Lauterbach, Abigail L, Cao, Shijie, Wilson, D Scott, Hubbell, Jeffrey A

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Polymersomes Decorated with the SARS-CoV‑2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity von Volpatti, Lisa R, Wallace, Rachel P, Cao, Shijie, Raczy, Michal M, Wang, Ruyi, Gray, Laura T, Alpar, Aaron T, Briquez, Priscilla S, Mitrousis, Nikolaos, Marchell, Tiffany M, Sasso, Maria Stella, Nguyen, Mindy, Mansurov, Aslan, Budina, Erica, Solanki, Ani, Watkins, Elyse A, Schnorenberg, Mathew R, Tremain, Andrew C, Reda, Joseph W, Nicolaescu, Vlad, Furlong, Kevin, Dvorkin, Steve, Yu, Shann S, Manicassamy, Balaji, LaBelle, James L, Tirrell, Matthew V, Randall, Glenn, Kwissa, Marcin, Swartz, Melody A, Hubbell, Jeffrey A

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