LAG3: a novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma von Keane, Colm, Law, Soi C., Gould, Clare, Birch, Simone, Sabdia, Muhammed B., Merida de Long, Lilia, Thillaiyampalam, Gayathri, Abro, Emad, Tobin, Joshua W., Tan, Xiaohong, Xu-Monette, Zijun Y., Young, Ken H., Gifford, Grace, Gabreilli, Sara, Stevenson, William S., Gill, Anthony, Talaulikar, Dipti, Jain, Sanjiv, Hernandez, Annette, Halliday, Sarah-Jane, Bird, Robert, Cross, Donna, Hertzberg, Mark, Gandhi, Maher K.

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EBV microRNA-BHRF1-2-5p targets the 3′UTR of immune checkpoint ligands PD-L1 and PD-L2 von Cristino, Alexandre S., Nourse, Jamie, West, Rachael A., Sabdia, Muhammed Bilal, Law, Soi C., Gunawardana, Jay, Vari, Frank, Mujaj, Sally, Thillaiyampalam, Gayathri, Snell, Cameron, Gough, Madeline, Keane, Colm, Gandhi, Maher K.

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Successful treatment of Epstein–Barr virus–associated primary central nervous system lymphoma due to post‐transplantation lymphoproliferative disorder, with ibrutinib and third‐par... von Law, Soi C., Hoang, Thanh, O'Rourke, Kacey, Tobin, Joshua W. D., Gunawardana, Jay, Loo‐Oey, Dorothy, Bednarska, Karolina, Merida de Long, Lilia, Sabdia, Muhammed B., Hapgood, Greg, Blyth, Emily, Clancy, Leighton, Hennig, Stefanie, Keane, Colm, Gandhi, Maher K.

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Intra‐tumoral and peripheral blood TIGIT and PD‐1 as immune biomarkers in nodular lymphocyte predominant Hodgkin lymphoma von Gunawardana, Jay, Law, Soi C., Sabdia, Muhammed B., Fennell, Éanna, Hennessy, Aoife, Leahy, Ciara I., Murray, Paul G., Bednarska, Karolina, Brosda, Sandra, Trotman, Judith, Berkahn, Leanne, Zaharia, Andreea, Birch, Simone, Burgess, Melinda, Talaulikar, Dipti, Lee, Justina N., Jude, Emily, Hawkes, Eliza A., Jain, Sanjiv, Nath, Karthik, Snell, Cameron, Swain, Fiona, Tobin, Joshua W. D., Keane, Colm, Shanavas, Mohamed, Blyth, Emily, Steidl, Christian, Savage, Kerry, Farinha, Pedro, Boyle, Merrill, Meissner, Barbara, Green, Michael R., Vega, Francisco, Gandhi, Maher K.

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Resolution of Melanoma to Programmed Death-1 Blockade but Simultaneous Rapid Progression of Concomitant Chronic Lymphocytic Leukemia von Burgess, Melinda, Keane, Colm, Tobin, Josh WD, Law, Soi C., Griffin, Alison, Gill, Devinder, Ewing, Adam D., Atkinson, Victoria, Mollee, Peter, Sabdia, Muhammed B., Saunders, Nicholas A., Gandhi, Maher K.

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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... von MacManus, Michael P., Seymour, John F., Tsang, Hennes, Fisher, Richard, Keane, Colm, Sabdia, Muhammed B., Law, Soi C., Gunawardana, Jay, Nath, Karthik, Kazakoff, Stephen H., Marques-Piubelli, Mario L., Duenas, Daniela E., Green, Michael R., Roos, Daniel, O'Brien, Peter, McCann, Andrew, Tsang, Richard, Davis, Sidney, Christie, David, Cheah, Chan, Amanuel, Benhur, Cochrane, Tara, Butler, Jason, Johnston, Anna, Shanavas, Mohamed, Li, Li, Vajdic, Claire, Kridel, Robert, Shelton, Victoria, Hershenfield, Samantha, Baetz, Tara, Lebrun, David, Johnson, Nathalie, Brodtkorb, Marianne, Ludvigsen, Maja, d’Amore, Francesco, Thompson, Ella R., Blombery, Piers, Gandhi, Maher K., Tobin, Joshua W.D.

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INTRATUMORAL T‐CELLS HAVE A DIFFERENTIAL IMPACT ON FDG‐PET PARAMETERS IN FOLLICULAR LYMPHOMA von Nath, K., Law, Soi‐C., Talaulikar, D., Sabdia, M. B., Gunawardana, J., de Long, L. M., Shanavas, M., Tsang, H., Tobin, J. W., Halliday, S.‐J., Hernandez, A., Cross, D., Bird, R., Jain, S., Keane, C., Trotman, J., Law, P., Gandhi, M. K.

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Type 1 diabetes: a disease of developmental origins von Phillips, Jessica E., Couper, Jennifer J., Penno, Megan A.S., Harrison, Leonard C., Anderson, Heather, Bandala‐Sanchez, Esther, Barry, Simon C, Baskerville, Tracey, Battersby, Rachel, Bediaga, Naiara G, Bezuidenhout, Debra, Brownrigg, Emma, Catteau, Jacki, Choo, Ace, Colman, Peter G, Cotterill, Andrew, Couper, Jennifer J, Craig, Maria E, Curran, Sheryl, Davis, Elizabeth A, Dodd, Jodie M, Edwards, Danielle, French, Jane, Gibson, Emily, Giles, Lynne C, Gwiazdzinski, Alison, Harris, Mark, Harrison, Leonard C, Haynes, Aveni, Hope, Christopher M, Hsieh, Cecilia, Huang, Dexing, Hu, William, Keytash, Azita, Krieg, Meredith, Law, Soi C, Lloyd‐Johnsen, Catherine, Morahan, Grant, Neale, Alana M, Ngui, Katrina, Papenfuss, Anthony T, Penno, Megan AS, Poth, Megan, Ramoso, Benjamin, Rawlinson, William D, Roberts, Alison, Sadlon, Timothy J, Schulze, Alexandra, Penington, Jocelyn Sietsma, Sinnott, Richard O, Spooner, Kelly, Stone, Natalie L, Thomson, Rebecca L, Toome, Sarah, Tully, Alexandra, Vuillermin, Peter J, Watson, Kelly, Wentworth, John M, Wilson, Julianne

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T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles von Law, Soi Cheng, Street, Shayna, Yu, Chien-Hsiung Alan, Capini, Christelle, Ramnoruth, Sakoontalla, Nel, Hendrik J, van Gorp, Eline, Hyde, Claire, Lau, Kim, Pahau, Helen, Purcell, Anthony W, Thomas, Ranjeny

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The NLPHL Tumor Microenvironment Is Markedly Enriched in the Tigit and PD-1 Signalling Axes Compared to Classical Hodgkin Lymphoma von Gunawardana, Jay, Sabdia, Muhammed B., Bednarska, Karolina, Law, Soi C., Brosda, Sandra, Tsang, Hennes, De Long, Lilia Merida, Zaharia, Andreea, Lee, Justina, Jude, Emily, Hawkes, Eliza, Nath, Karthik, Gould, Clare, Burgess, Melinda Lea, Swain, Fiona, Tobin, Joshua W.D., Keane, Colm, Birch, Simone, Talaulikar, Dipti, Jain, Sanjiv, Shanavas, Mohamed, Snell, Cameron, Gandhi, Maher

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The Tumor Microenvironment of Nodular Lymphocyte Predominant Hodgkin Lymphoma Is a Unique Immunobiological Entity Distinct from Classical Hodgkin Lymphoma von Gunawardana, Jay, Bednarska, Karolina, Law, Soi C, Lee, Justina, Sabdia, Muhammed Bilal, Tobin, Joshua W.D., Birch, Simone, Keane, Colm, Gandhi, Maher K

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Intra-Tumoral CD8+ T-Cells in Follicular Lymphoma Contain Large Clonal Expansions That Are Amenable to Dual-Checkpoint Blockade von Nath, Karthik, Law, Soi C., Sabdia, Muhammed B., De Long, Lilia Merida, Shanavas, Mohamed, Tobin, Joshua W.D., Gunawardana, Jay, Vari, Frank, Halliday, Sarah-Jane, Hernandez, Annette, Cross, Donna, Bird, Robert J., Keane, Colm, Gandhi, Maher K.

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Neoantigens Are Typically Associated with Intact HLA Class I Presentation in Early-Stage Follicular Lymphoma von Tsang, Hennes, Patch, Ann-Marie, Keane, Colm, Law, Soi C., Gunawardana, Jay, Blombery, Piers, Thompson, Ella R, Sabdia, Muhammed B., De Long, Lilia Merida, Belle, Clemence J, Nath, Karthik, Tobin, Joshua W.D., Kazakoff, Stephen H, Seymour, John F., MacManus, Michael, Gandhi, Maher K.

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A Critical Role for Intratumoral and Circulating LAG3 in Classical Hodgkin Lymphoma: Analysis from the Rathl Prospective Phase III International Clinical Trial von Abro, Emad Uddin, Law, Soi C, Keane, Colm, Birch, Simone, Sabdia, Muhammed Bilal, Tobin, Joshua W.D., Johnson, Peter, Trotman, Judith, Berkahn, Leanne, Fulham, Michael, Anderson, Richard A, Saunderson, Anne L, Gunawardana, Jay, Cross, Donna, Hernandez, Annette, Halliday, Sarah-Jane, Bird, Robert, Law, W P, Gill, Devinder, Gandhi, Maher K

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Elevated LAG-3 Expression in the Tumor Microenvironement of Patients with DLBCL Is Associated with a Non-GCB Phenotype and Poor Prognosis von Keane, Colm, Law, Soi C, Gould, Clare, Francis, Santiyagu, Abro, Emad Uddin, Tobin, Joshua W.D., Birch, Simone, Gifford, Grace, Gabreilli, Sara, Stevenson, William S., Talaulikar, Dipti, Gill, Anthony, Jain, Sanjiv, Cross, Donna, Hernadez, Annette, Halliday, Sarah-Jane, Bird, Robert, Hertzberg, Mark, Gandhi, Maher K

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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... von Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

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Abstract A17: The immune checkpoints TIGIT and PD-1 are markedly upregulated in NLPHL compared to classical Hodgkin Lymphoma von Gunawardana, Jay, Law, Soi C., Sabdia, Muhammed B., Bednarska, Karolina, Brosda, Sandra, Zaharia, Andreea, Tsang, Hennes, de Long, Lilia M., Burgess, Melinda, Talaulikar, Dipti, Lee, Justina N., Jude, Emily, Hawkes, Eliza A., Jain, Sanjiv, Nath, Karthik, Gould, Clare, Swain, Fiona, Tobin, Joshua W. D., Keane, Colm, Birch, Simone, Shanavas, Mohamed, Snell, Cameron, Gandhi, Maher K.

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EBV microRNA-BHRF1-2-5p targets the 3'UTR of immune checkpoint ligands PD-L1 and PD-L2 von Cristino, Alexandre S, Nourse, Jamie, West, Rachael A, Sabdia, Muhammed Bilal, Law, Soi C, Gunawardana, Jay, Vari, Frank, Mujaj, Sally, Thillaiyampalam, Gayathri, Snell, Cameron, Gough, Madeline, Keane, Colm, Gandhi, Maher K

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Resolution of Melanoma to Programmed Death-1 Blockade but Simultaneous Rapid Progression of Concomitant Chronic Lymphocytic Leukemia von Burgess, Melinda, Keane, Colm, Tobin, Josh Wd, Law, Soi C, Griffin, Alison, Gill, Devinder, Ewing, Adam D, Atkinson, Victoria, Mollee, Peter, Sabdia, Muhammed B, Saunders, Nicholas A, Gandhi, Maher K

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Successful treatment of Epstein-Barr virus-associated primary central nervous system lymphoma due to post-transplantation lymphoproliferative disorder, with ibrutinib and third-par... von Law, Soi C, Hoang, Thanh, O'Rourke, Kacey, Tobin, Joshua W D, Gunawardana, Jay, Loo-Oey, Dorothy, Bednarska, Karolina, Merida de Long, Lilia, Sabdia, Muhammed B, Hapgood, Greg, Blyth, Emily, Clancy, Leighton, Hennig, Stefanie, Keane, Colm, Gandhi, Maher K

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