In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir von Tong, Xiao, Le Pogam, Sophie, Li, Lewyn, Haines, Kristin, Piso, Katherine, Baronas, Victoria, Yan, Jun-Mei, So, Sung-Sau, Klumpp, Klaus, Nájera, Isabel

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Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development von Zhang, Zhuming, Chu, Xin-Jie, Liu, Jin-Jun, Ding, Qingjie, Zhang, Jing, Bartkovitz, David, Jiang, Nan, Karnachi, Prabha, So, Sung-Sau, Tovar, Christian, Filipovic, Zoran M, Higgins, Brian, Glenn, Kelli, Packman, Kathryn, Vassilev, Lyubomir, Graves, Bradford

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Design of Libraries Targeting Protein-Protein Interfaces von Fry, David, Huang, Kuo-Sen, Di Lello, Paola, Mohr, Peter, Müller, Klaus, So, Sung-Sau, Harada, Takeo, Stahl, Martin, Vu, Binh, Mauser, Harald

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Overview of Artificial Neural Networks von Zou, Jinming, Han, Yi, So, Sung-Sau

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Discovery of 2‑[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thy... von Kelly, Martha J, Pietranico-Cole, Sherrie, Larigan, J. Douglas, Haynes, Nancy-Ellen, Reynolds, Charles H, Scott, Nathan, Vermeulen, John, Dvorozniak, Mark, Conde-Knape, Karin, Huang, Kuo-Sen, So, Sung-Sau, Thakkar, Kshitij, Qian, Yimin, Banner, Bruce, Mennona, Frank, Danzi, Sara, Klein, Irwin, Taub, Rebecca, Tilley, Jefferson

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A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation von Lopez-Tapia, Francisco, Lou, Yan, Brotherton-Pleiss, Christine, Kuglstatter, Andreas, So, Sung-Sau, Kondru, Rama

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Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods von Gathiaka, Symon, Palte, Rachel L., So, Sung-Sau, Chai, Xiaomei, Richard Miller, J., Kuvelkar, Reshma, Wen, Xiujuan, Cifelli, Steven, Kreamer, Anthony, Liaw, Andy, McLaren, David G., Fischer, Christian

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A Crowd-Based Process and Tool for HTS Hit Triage von Peng, Zhengwei, Gillespie, Paul, Weisel, Martin, So, Sung-Sau, So, W. Venus, Kondru, Rama, Narayanan, Arjun, Hermann, Johannes C.

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Enhancing Specificity and Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Chemical and Shape Features−A Case Study of HIV Protease Inhibitors von Pandit, Deepangi, So, Sung-Sau, Sun, Hongmao

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Evolutionary Optimization in Quantitative Structure−Activity Relationship:  An Application of Genetic Neural Networks von So, Sung-Sau, Karplus, Martin

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Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy von Byrne, Noel J., Lee, Amy C., Kostas, James, Reid, John C., Partridge, Andrea T., So, Sung-Sau, Cowan, Joseph E., Abeywickrema, Pravien, Huang, Hua, Zebisch, Matthias, Barker, John J., Soisson, Stephen M., Brooun, Alexei, Su, Hua-Poo

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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors von Kühne, Holger, Obst-Sander, Ulrike, Kuhn, Bernd, Conte, Aurelia, Ceccarelli, Simona M., Neidhart, Werner, Rudolph, Markus G., Ottaviani, Giorgio, Gasser, Rodolfo, So, Sung-Sau, Li, Shirley, Zhang, Xiaolei, Gao, Lin, Myers, Michael

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Fragment Library Design: Using Cheminformatics and Expert Chemists to Fill Gaps in Existing Fragment Libraries von Kutchukian, Peter S., So, Sung-Sau, Fischer, Christian, Waller, Chris L.

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Automated Pharmacophore Query Optimization with Genetic AlgorithmsA Case Study Using the MC4R System von Jia, Lei, Zou, Jinming, So, Sung-Sau, Sun, Hongmao

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Genetic Neural Networks for Quantitative Structure−Activity Relationships:  Improvements and Application of Benzodiazepine Affinity for Benzodiazepine/GABAA Receptors von So, Sung-Sau, Karplus, Martin

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Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists von Gillespie, Paul, Goodnow, Robert A., Saha, Goutam, Bose, Gopal, Moulik, Kakali, Zwingelstein, Catherine, Myers, Michael, Conde-Knape, Karin, Pietranico-Cole, Sherrie, So, Sung-Sau

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Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibit... von Chu, Xin-Jie, DePinto, Wanda, Bartkovitz, David, So, Sung-Sau, Vu, Binh T, Packman, Kathryn, Lukacs, Christine, Ding, Qingjie, Jiang, Nan, Wang, Ka, Goelzer, Petra, Yin, Xuefeng, Smith, Melissa A, Higgins, Brian X, Chen, Yingsi, Xiang, Qing, Moliterni, John, Kaplan, Gerald, Graves, Bradford, Lovey, Allen, Fotouhi, Nader

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Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs von Qian, Yimin, Conde-Knape, Karin, Erickson, Shawn D., Falcioni, Fiorenza, Gillespie, Paul, Hakimi, Irina, Mennona, Francis, Ren, Yonglin, Salari, Hamid, So, Sung-Sau, Tilley, Jefferson W.

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Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors von Qian, Yimin, Ahmad, Mushtaq, Chen, Shaoqing, Gillespie, Paul, Le, Nam, Mennona, Frank, Mischke, Steven, So, Sung-Sau, Wang, Hong, Burghardt, Charles, Tannu, Shahid, Conde-Knape, Karin, Kochan, Jarema, Bolin, David

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Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors von Gillespie, Paul, Pietranico-Cole, Sherrie, Myers, Michael, Bilotta, Joseph A., Conde-Knape, Karin, Fotouhi, Nader, Goodnow, Robert A., Guertin, Kevin R., Hamilton, Matthew M., Haynes, Nancy-Ellen, Liu, Baolian, Qi, Lida, Ren, Yonglin, Scott, Nathan R., So, Sung-Sau, Spence, Cheryl, Taub, Rebecca, Thakkar, Kshitij, Tilley, Jefferson W., Zwingelstein, Catherine

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