Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy von Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.

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Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation von Burgener, Sabrina Sofia, Leborgne, Nathan Georges François, Snipas, Scott J., Salvesen, Guy S., Bird, Phillip Ian, Benarafa, Charaf

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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design von Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J., El Oualid, Farid, Huang, Tony T., Bekes, Miklos, Drag, Marcin, Olsen, Shaun K.

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Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling von Kasperkiewicz, Paulina, Poreba, Marcin, Snipas, Scott J., Parker, Heather, Winterbourn, Christine C., Salvesen, Guy S., Drag, Marcin

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Selective chemical reagents to investigate the role of caspase 6 in apoptosis in acute leukemia T cells von Groborz, Katarzyna M, Kalinka, Małgorzata, Grzymska, Justyna, Kołt, Sonia, Snipas, Scott J, Poręba, Marcin

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Cell organelles are retained inside pyroptotic corpses during inflammatory cell death von Hempel, Anne, D'Osualdo, Andrea, Snipas, Scott J, Salvesen, Guy S

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Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes von Poreba, Marcin, Solberg, Rigmor, Rut, Wioletta, Lunde, Ngoc Nguyen, Kasperkiewicz, Paulina, Snipas, Scott J., Mihelic, Marko, Turk, Dusan, Turk, Boris, Salvesen, Guy S., Drag, Marcin

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Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4 von Kasperkiewicz, Paulina, Poreba, Marcin, Snipas, Scott J, Lin, S Jack, Kirchhofer, Daniel, Salvesen, Guy S, Drag, Marcin

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SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth von Tamiya, Hironari, Kim, Hyungsoo, Klymenko, Oleksiy, Kim, Heejung, Feng, Yongmei, Zhang, Tongwu, Han, Ji Yun, Murao, Ayako, Snipas, Scott J, Jilaveanu, Lucia, Brown, Kevin, Kluger, Harriet, Zhang, Hao, Iwai, Kazuhiro, Ronai, Ze'ev A

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Caspase-9 inhibition confers stronger neuronal and vascular protection compared to VEGF neutralization in a mouse model of retinal vein occlusion von Avrutsky, Maria I, Chen, Claire W, Lawson, Jacqueline M, Snipas, Scott J, Salvesen, Guy S, Troy, Carol M

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Mechanism and specificity of the human paracaspase MALT1 von Hachmann, Janna, Snipas, Scott J, van Raam, Bram J, Cancino, Erik M, Houlihan, Emily J, Poreba, Marcin, Kasperkiewicz, Paulina, Drag, Marcin, Salvesen, Guy S

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Structural and kinetic determinants of protease substrates von Snipas, Scott J, Salvesen, Guy S, Regan, Tim, Timmer, John C, Eroshkin, Alexey M, Pop, Cristina, Zhu, Wenhong, Riedl, Stefan J

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Glycosylation Broadens the Substrate Profile of Membrane Type 1 Matrix Metalloproteinase von Wu, Yi I., Munshi, Hidayatullah G., Sen, Ratna, Snipas, Scott J., Salvesen, Guy S., Fridman, Rafael, Stack, M. Sharon

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Cathepsin D Primes Caspase-8 Activation by Multiple Intra-chain Proteolysis von Conus, Sébastien, Pop, Cristina, Snipas, Scott J., Salvesen, Guy S., Simon, Hans-Uwe

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Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide von Günther, Saskia D., Fritsch, Melanie, Seeger, Jens M., Schiffmann, Lars M., Snipas, Scott J., Coutelle, Maria, Kufer, Thomas A., Higgins, Paul G., Hornung, Veit, Bernardini, Maria L., Höning, Stefan, Krönke, Martin, Salvesen, Guy S., Kashkar, Hamid

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Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11 von Bibo-Verdugo, Betsaida, Snipas, Scott J., Kolt, Sonia, Poreba, Marcin, Salvesen, Guy S.

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling von Kayagaki, Nobuhiko, Stowe, Irma B., Lee, Bettina L., O’Rourke, Karen, Anderson, Keith, Warming, Søren, Cuellar, Trinna, Haley, Benjamin, Roose-Girma, Merone, Phung, Qui T., Liu, Peter S., Lill, Jennie R., Li, Hong, Wu, Jiansheng, Kummerfeld, Sarah, Zhang, Juan, Lee, Wyne P., Snipas, Scott J., Salvesen, Guy S., Morris, Lucy X., Fitzgerald, Linda, Zhang, Yafei, Bertram, Edward M., Goodnow, Christopher C., Dixit, Vishva M.

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Caspase selective reagents for diagnosing apoptotic mechanisms von Poreba, Marcin, Groborz, Katarzyna, Navarro, Mario, Snipas, Scott J., Drag, Marcin, Salvesen, Guy S.

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NETosis occurs independently of neutrophil serine proteases von Kasperkiewicz, Paulina, Hempel, Anne, Janiszewski, Tomasz, Kołt, Sonia, Snipas, Scott J., Drag, Marcin, Salvesen, Guy S.

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Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1 von Ramirez, Monica L. Gonzalez, Poreba, Marcin, Snipas, Scott J., Groborz, Katarzyna, Drag, Marcin, Salvesen, Guy S.

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