The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension von te Velthuis, Aartjan J.W., van den Worm, Sjoerd H. E., Snijder, Eric J.

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Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design von Malone, Brandon, Urakova, Nadya, Snijder, Eric J., Campbell, Elizabeth A.

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Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements von Manfredonia, Ilaria, Nithin, Chandran, Ponce-Salvatierra, Almudena, Ghosh, Pritha, Wirecki, Tomasz K, Marinus, Tycho, Ogando, Natacha S, Snijder, Eric J, van Hemert, Martijn J, Bujnicki, Janusz M, Incarnato, Danny

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A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis von Snijder, Eric J., Limpens, Ronald W. A. L., de Wilde, Adriaan H., de Jong, Anja W. M., Zevenhoven-Dobbe, Jessika C., Maier, Helena J., Faas, Frank F. G. A., Koster, Abraham J., Barcena, Montserrat

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The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2 von Ogando, Natacha S., Zevenhoven-Dobbe, Jessika C., van der Meer, Yvonne, Bredenbeek, Peter J., Posthuma, Clara C., Snijder, Eric J.

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In vitro reconstitution of SARS-coronavirus mRNA cap methylation von Bouvet, Mickaël, Debarnot, Claire, Imbert, Isabelle, Selisko, Barbara, Snijder, Eric J, Canard, Bruno, Decroly, Etienne

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SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology von Ogando, Natacha S., Dalebout, Tim J., Zevenhoven-Dobbe, Jessika C., Limpens, Ronald W. A. L., van der Meer, Yvonne, Caly, Leon, Druce, Julian, de Vries, Jutte J. C., Kikkert, Marjolein, Barcena, Montserrat, Sidorov, Igor, Snijder, Eric J.

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A molecular pore spans the double membrane of the coronavirus replication organelle von Wolff, Georg, Limpens, Ronald W. A. L., Zevenhoven-Dobbe, Jessika C., Laugks, Ulrike, Zheng, Shawn, de Jong, Anja W. M., Koning, Roman, Agard, David A., Grunewald, Kay, Koster, Abraham J., Snijder, Eric J., Barcena, Montserrat

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities von Subissi, Lorenzo, Posthuma, Clara C, Collet, Axelle, Zevenhoven-Dobbe, Jessika C, Gorbalenya, Alexander E, Decroly, Etienne, Snijder, Eric J, Canard, Bruno, Imbert, Isabelle

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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity von Ogando, Natacha S, Ferron, Francois, Decroly, Etienne, Canard, Bruno, Posthuma, Clara C, Snijder, Eric J

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Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture von DE WILDE, Adriaan H, JOCHMANS, Dirk, POSTHUMA, Clara C, ZEVENHOVEN-DOBBE, Jessika C, VAN NIEUWKOOP, Stefan, BESTEBROER, Theo M, VAN DEN HOOGEN, Bernadette G, NEYTS, Johan, SNIJDER, Eric J

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Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronav... von Oudshoorn, Diede, Rijs, Kevin, Limpens, Ronald W A L, Groen, Kevin, Koster, Abraham J, Snijder, Eric J, Kikkert, Marjolein, Bárcena, Montserrat

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity von Schoggins, John W., MacDuff, Donna A., Imanaka, Naoko, Gainey, Maria D., Shrestha, Bimmi, Eitson, Jennifer L., Mar, Katrina B., Richardson, R. Blake, Ratushny, Alexander V., Litvak, Vladimir, Dabelic, Rea, Manicassamy, Balaji, Aitchison, John D., Aderem, Alan, Elliott, Richard M., García-Sastre, Adolfo, Racaniello, Vincent, Snijder, Eric J., Yokoyama, Wayne M., Diamond, Michael S., Virgin, Herbert W., Rice, Charles M.

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Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture von te Velthuis, Aartjan J W, van den Worm, Sjoerd H E, Sims, Amy C, Baric, Ralph S, Snijder, Eric J, van Hemert, Martijn J

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Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study von Schurink, Bernadette, Roos, Eva, Radonic, Teodora, Barbe, Ellis, Bouman, Catherine S C, de Boer, Hans H, de Bree, Godelieve J, Bulle, Esther B, Aronica, Eleonora M, Florquin, Sandrine, Fronczek, Judith, Heunks, Leo M A, de Jong, Menno D, Guo, Lihui, du Long, Romy, Lutter, Rene, Molenaar, Pam C G, Neefjes-Borst, E Andra, Niessen, Hans W M, van Noesel, Carel J M, Roelofs, Joris J T H, Snijder, Eric J, Soer, Eline C, Verheij, Joanne, Vlaar, Alexander P J, Vos, Wim, van der Wel, Nicole N, van der Wal, Allard C, van der Valk, Paul, Bugiani, Marianna

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Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes von Nga, Phan Thi, Parquet, Maria del Carmen, Lauber, Chris, Parida, Manmohan, Nabeshima, Takeshi, Yu, Fuxun, Thuy, Nguyen Thanh, Inoue, Shingo, Ito, Takashi, Okamoto, Kenta, Ichinose, Akitoyo, Snijder, Eric J, Morita, Kouichi, Gorbalenya, Alexander E

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Nonstructural Protein 2 of Porcine Reproductive and Respiratory Syndrome Virus Inhibits the Antiviral Function of Interferon-Stimulated Gene 15 von ZHI SUN, YANHUA LI, RANSBURGH, Russell, SNIJDER, Eric J, YING FANG

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Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans von van Boheemen, Sander, de Graaf, Miranda, Lauber, Chris, Bestebroer, Theo M, Raj, V Stalin, Zaki, Ali Moh, Osterhaus, Albert D M E, Haagmans, Bart L, Gorbalenya, Alexander E, Snijder, Eric J, Fouchier, Ron A M

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Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae von Wolff, Georg, Limpens, Ronald W.A.L., Zheng, Shawn, Snijder, Eric J., Agard, David A., Koster, Abraham J., Bárcena, Montserrat

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Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral von Delang, Leen, Segura Guerrero, Nidya, Tas, Ali, Quérat, Gilles, Pastorino, Boris, Froeyen, Mathy, Dallmeier, Kai, Jochmans, Dirk, Herdewijn, Piet, Bello, Felio, Snijder, Eric J, de Lamballerie, Xavier, Martina, Byron, Neyts, Johan, van Hemert, Martijn J, Leyssen, Pieter

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