Widespread seasonal gene expression reveals annual differences in human immunity and physiology von Dopico, Xaquin Castro, Evangelou, Marina, Ferreira, Ricardo C., Guo, Hui, Pekalski, Marcin L., Smyth, Deborah J., Cooper, Nicholas, Burren, Oliver S., Fulford, Anthony J., Hennig, Branwen J., Prentice, Andrew M., Ziegler, Anette-G., Bonifacio, Ezio, Wallace, Chris, Todd, John A.

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Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines von Cano-Gamez, Eddie, Soskic, Blagoje, Roumeliotis, Theodoros I., So, Ernest, Smyth, Deborah J., Baldrighi, Marta, Willé, David, Nakic, Nikolina, Esparza-Gordillo, Jorge, Larminie, Christopher G. C., Bronson, Paola G., Tough, David F., Rowan, Wendy C., Choudhary, Jyoti S., Trynka, Gosia

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Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases von Plagnol, Vincent, Howson, Joanna M M, Smyth, Deborah J, Walker, Neil, Hafler, Jason P, Wallace, Chris, Stevens, Helen, Jackson, Laura, Simmonds, Matthew J, Bingley, Polly J, Gough, Stephen C, Todd, John A

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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases von Ferreira, Ricardo C, Freitag, Daniel F, Cutler, Antony J, Howson, Joanna M M, Rainbow, Daniel B, Smyth, Deborah J, Kaptoge, Stephen, Clarke, Pamela, Boreham, Charlotte, Coulson, Richard M, Pekalski, Marcin L, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Butterworth, Adam S, Malarstig, Anders, Danesh, John, Todd, John A

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A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes von FERREIRA, Ricardo C, HUI GUO, LYONS, Paul A, SMITH, Kenneth G. C, ACHENBACH, Peter, BEYERLEIN, Andreas, DUNGER, David B, CLAYTON, David G, WICKER, Linda S, TODD, John A, BONIFACIO, Ezio, WALLACE, Chris, COULSON, Richard M. R, ZIEGLER, Anette-G, SMYTH, Deborah J, PEKALSKI, Marcin L, BURREN, Oliver S, CUTLER, Antony J, DOECKE, James D, FLINT, Shaun, MCKINNEY, Eoin F

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Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease von Smyth, Deborah J, Plagnol, Vincent, Walker, Neil M, Cooper, Jason D, Downes, Kate, Yang, Jennie H.M, Howson, Joanna M.M, Stevens, Helen, McManus, Ross, Wijmenga, Cisca, Heap, Graham A, Dubois, Patrick C, Clayton, David G, Hunt, Karen A, van Heel, David A, Todd, John A

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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci von Cooper, Jason D, Smyth, Deborah J, Smiles, Adam M, Plagnol, Vincent, Walker, Neil M, Allen, James E, Downes, Kate, Barrett, Jeffrey C, Healy, Barry C, Mychaleckyj, Josyf C, Warram, James H, Todd, John A

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Reduced expression of IFIH1 is protective for type 1 diabetes von Downes, Kate, Pekalski, Marcin, Angus, Karen L, Hardy, Matthew, Nutland, Sarah, Smyth, Deborah J, Walker, Neil M, Wallace, Chris, Todd, John A

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase ( IFIH1 ) region von Todd, John A, Smyth, Deborah J, Cooper, Jason D, Bailey, Rebecca, Field, Sarah, Burren, Oliver, Smink, Luc J, Guja, Cristian, Ionescu-Tirgoviste, Constantin, Widmer, Barry, Dunger, David B, Savage, David A, Walker, Neil M, Clayton, David G

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Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes von Bailey, Rebecca, Smyth, Deborah J, Atkinson, Mark, Plagnol, Vincent, Brusko, Todd, Lowe, Christopher E, Field, Sarah, Wicker, Linda S, Bourget, Kirsi, Walker, Neil M, Todd, John A, Clayton, David G, Cooper, Jason D

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FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection von Smyth, Deborah J, Cooper, Jason D, Howson, Joanna M M, Clarke, Pamela, Downes, Kate, Mistry, Trupti, Stevens, Helen, Walker, Neil M, Todd, John A

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Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping von Wallace, Chris, Cutler, Antony J, Pontikos, Nikolas, Pekalski, Marcin L, Burren, Oliver S, Cooper, Jason D, García, Arcadio Rubio, Ferreira, Ricardo C, Guo, Hui, Walker, Neil M, Smyth, Deborah J, Rich, Stephen S, Onengut-Gumuscu, Suna, Sawcer, Stephen J, Ban, Maria, Richardson, Sylvia, Todd, John A, Wicker, Linda S

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Population structure, differential bias and genomic control in a large-scale, case-control association study von Clayton, David G, Todd, John A, Walker, Neil M, Smyth, Deborah J, Pask, Rebecca, Cooper, Jason D, Maier, Lisa M, Smink, Luc J, Lam, Alex C, Ovington, Nigel R, Stevens, Helen E, Nutland, Sarah, Howson, Joanna M M, Faham, Malek, Moorhead, Martin, Jones, Hywel B, Falkowski, Matthew, Hardenbol, Paul, Willis, Thomas D

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Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes von WALLACE, Chris, ROTIVAL, Maxime, TODD, John A, CLAYTON, David G, BLANKENBERG, Stefan, COOPER, Jason D, RICE, Catherine M, YANG, Jennie H. M, MCNEILL, Mhairi, SMYTH, Deborah J, NIBLETT, David, CAMBIEN, François, TIRET, Laurence

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Genetic Analysis of Adult-Onset Autoimmune Diabetes von HOWSON, Joanna M. M, ROSINGER, Silke, SMYTH, Deborah J, BOEHM, Bernhard O, TODD, John A

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Association of the Vitamin D Metabolism Gene CYP27B1 With Type 1 Diabetes von BAILEY, Rebecca, COOPER, Jason D, NEJENTSEV, Sergey, TODD, John A, ZEITELS, Lauren, SMYTH, Deborah J, YANG, Jennie H. M, WALKER, Neil M, HYPPÖNEN, Elina, DUNGER, David B, RAMOS-LOPEZ, Elizabeth, BADENHOOP, Klaus

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A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations von Evangelou, Marina, Smyth, Deborah J., Fortune, Mary D., Burren, Oliver S., Walker, Neil M., Guo, Hui, Onengut-Gumuscu, Suna, Chen, Wei-Min, Concannon, Patrick, Rich, Stephen S., Todd, John A., Wallace, Chris

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Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes von HOWSON, Joanna M. M, COOPER, Jason D, CONCANNON, Patrick, ERLICH, Henry A, JULIER, Cecile, GRANT-MORAHAN, NERUP, Jørn, NIERRAS, Concepcion, POCIOT, Flemming, RICH, Stephen S, SMYTH, Deborah J, WALKER, Neil M, STEVENS, Helen, SHE, Jin-Xiong, EISENBARTH, George S, REWERS, Marian, TODD, John A, AKOLKAR, Beena

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Immune disease variants modulate gene expression in regulatory CD4+ T cells von Bossini-Castillo, Lara, Glinos, Dafni A., Kunowska, Natalia, Golda, Gosia, Lamikanra, Abigail A., Spitzer, Michaela, Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Cattermole, Claire, Alasoo, Kaur, Mann, Alice, Kundu, Kousik, Lorenc, Anna, Soranzo, Nicole, Dunham, Ian, Roberts, David J., Trynka, Gosia

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A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3 von Concannon, Patrick, Onengut-Gumuscu, Suna, Todd, John A, Smyth, Deborah J, Pociot, Flemming, Bergholdt, Regine, Akolkar, Beena, Erlich, Henry A, Hilner, Joan E, Julier, Cécile, Morahan, Grant, Nerup, Jørn, Nierras, Concepcion R, Chen, Wei-Min, Rich, Stephen S

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