IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study von Li, Yunlei, Buijs-Gladdines, Jessica G C A M, Canté-Barrett, Kirsten, Stubbs, Andrew P, Vroegindeweij, Eric M, Smits, Willem K, van Marion, Ronald, Dinjens, Winand N M, Horstmann, Martin, Kuiper, Roland P, Buijsman, Rogier C, Zaman, Guido J R, van der Spek, Peter J, Pieters, Rob, Meijerink, Jules P P

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The role of the mineralocorticoid receptor in steroidinduced cytotoxicity in pediatric acute lymphoblastic leukemia von Van Hulst, Annelienke M, Van der Zwet, Jordy C G, Buijs-Gladdines, Jessica G C A M, Smits, Willem K, Fiocco, Marta, Pieters, Rob, Van Leeuwen, Frank N, Van den Heuvel-Eibrink, Marry M, Van den Akker, Erica L T, Meijerink, Jules P P

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STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment von Van der Zwet, Jordy C G, Cordo', Valentina, Buijs-Gladdines, Jessica G C A M, Hagelaar, Rico, Smits, Willem K, Vroegindeweij, Eric, Graus, Laura T M, Poort, Vera, Nulle, Marloes, Pieters, Rob, Meijerink, Jules P P

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Framework for capacity based sustainable design & development: towards resilient communities von Maria Smits, Michaël Willem

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The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia von Zuurbier, Linda, Petricoin, 3rd, Emanuel F, Vuerhard, Maartje J, Calvert, Valerie, Kooi, Clarissa, Buijs-Gladdines, Jessica G C A M, Smits, Willem K, Sonneveld, Edwin, Veerman, Anjo J P, Kamps, Willem A, Horstmann, Martin, Pieters, Rob, Meijerink, Jules P P

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Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation von Gachet, Stéphanie, El-Chaar, Tiama, Avran, David, Genesca, Eulalia, Catez, Frédéric, Quentin, Samuel, Delord, Marc, Thérizols, Gabriel, Briot, Delphine, Meunier, Godelieve, Hernandez, Lucie, Pla, Marika, Smits, Willem K, Buijs-Gladdines, Jessica G, Van Loocke, Wouter, Menschaert, Gerben, André-Schmutz, Isabelle, Taghon, Tom, Van Vlierberghe, Pieter, Meijerink, Jules P, Baruchel, André, Dombret, Hervé, Clappier, Emmanuelle, Diaz, Jean-Jacques, Gazin, Claude, de Thé, Hugues, Sigaux, François, Soulier, Jean

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MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance von van der Zwet, Jordy C. G., Buijs-Gladdines, Jessica G. C. A. M., Cordo’, Valentina, Debets, Donna O., Smits, Willem K., Chen, Zhongli, Dylus, Jelle, Zaman, Guido J. R., Altelaar, Maarten, Oshima, Koichi, Bornhauser, Beat, Bourquin, Jean-Pierre, Cools, Jan, Ferrando, Adolfo A., Vormoor, Josef, Pieters, Rob, Vormoor, Britta, Meijerink, Jules P. P.

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Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia von Smits, Willem K., Vermeulen, Carlo, Hagelaar, Rico, Kimura, Shunsuke, Vroegindeweij, Eric M., Buijs-Gladdines, Jessica G.C.A.M., van de Geer, Ellen, Verstegen, Marjon J.A.M., Splinter, Erik, van Reijmersdal, Simon V., Buijs, Arjan, Galjart, Niels, van Eyndhoven, Winfried, van Min, Max, Kuiper, Roland, Kemmeren, Patrick, Mullighan, Charles G., de Laat, Wouter, Meijerink, Jules P.P.

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Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors von Zuurbier, Linda, Gutierrez, Alejandro, Mullighan, Charles G, Canté-Barrett, Kirsten, Gevaert, A Olivier, de Rooi, Johan, Li, Yunlei, Smits, Willem K, Buijs-Gladdines, Jessica G C A M, Sonneveld, Edwin, Look, A Thomas, Horstmann, Martin, Pieters, Rob, Meijerink, Jules P P

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Toward self-reliant development: Capacity gap within the built environment of Mt. Elgon rural inhabitants von Michaël Willem Maria Smits

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PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events von Mendes, Rui D., Sarmento, Leonor M., Canté-Barrett, Kirsten, Zuurbier, Linda, Buijs-Gladdines, JessicaG.C.A.M., Póvoa, Vanda, Smits, Willem K., Abecasis, Miguel, Yunes, J. Andres, Sonneveld, Edwin, Horstmann, Martin A., Pieters, Rob, Barata, João T., Meijerink, JulesP.P.

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A quasi-experimental method for testing rural design support within a DRM framework von Michaël Willem Maria Smits

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MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus von Canté-Barrett, Kirsten, Meijer, Mariska T., Cordo’, Valentina, Hagelaar, Rico, Yang, Wentao, Yu, Jiyang, Smits, Willem K., Nulle, Marloes E., Jansen, Joris P., Pieters, Rob, Yang, Jun J., Haigh, Jody J., Goossens, Steven, Meijerink, Jules P.P.

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In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia von Homminga, Irene, Zwaan, C. Michel, Manz, Chantal Y., Parker, Cynthia, Bantia, Shanta, Smits, Willem Korstiaan, Higginbotham, Fiona, Pieters, Rob, Meijerink, Jules P.P.

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Lentiviral gene transfer into human and murine hematopoietic stem cells: size matters von Canté-Barrett, Kirsten, Mendes, Rui D, Smits, Willem K, van Helsdingen-van Wijk, Yvette M, Pieters, Rob, Meijerink, Jules P P

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Recurrent NR3C1 Aberrations at First Diagnosis Relate to Steroid Resistance in Pediatric T‐Cell Acute Lymphoblastic Leukemia Patients von Zwet, Jordy C. G., Smits, Willem, Buijs‐Gladdines, Jessica G. C. A. M., Pieters, Rob, Meijerink, Jules P. P.

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Manipulating MEF2C: Discovering Novel Drugs to Target ETP-ALL von Meijer, Mariska T., Cordo', Valentina, Hagelaar, Rico, Smits, Willem K., Meijerink, Jules PP

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MAPK-ERK Pathway Activation: The Achilles' Heel of IL-7R‒Induced Steroid Resistance von Van Der Zwet, Jordy C.G., Buijs-Gladdines, Jessica G.C.A.M., Smits, Willem K., Chen, Zhongli, Meijerink, Jules P.P.

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The role of the mineralocorticoid receptor in steroid-induced cytotoxicity in pediatric acute lymphoblastic leukemia von Van Hulst, Annelienke M., Van der Zwet, Jordy C.G., Buijs-Gladdines, Jessica G.C.A.M., Smits, Willem K., Fiocco, Marta, Pieters, Rob, Van Leeuwen, Frank N., Van den Heuvel-Eibrink, Marry M., Van den Akker, Erica L.T., Meijerink, Jules P.P.

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STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL and BCLXL following glucocorticoid treatment von van der Zwet, Jordy C.G., Cordo’, Valentina, Buijs-Gladdines, Jessica G.C.A.M., Hagelaar, Rico, Smits, Willem K., Vroegindeweij, Eric, Graus, Laura T.M., Poort, Vera M., Nulle, Marloes, Pieters, Rob, Meijerink, Jules P.P.

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