A Vaccinia-based system for directed evolution of GPCRs in mammalian cells von Klenk, Christoph, Scrivens, Maria, Niederer, Anina, Shi, Shuying, Mueller, Loretta, Gersz, Elaine, Zauderer, Maurice, Smith, Ernest S., Strohner, Ralf, Plückthun, Andreas

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Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity von Evans, Elizabeth E, Mishra, Vikas, Mallow, Crystal, Gersz, Elaine M, Balch, Leslie, Howell, Alan, Reilly, Christine, Smith, Ernest S, Fisher, Terrence L, Zauderer, Maurice

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SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease von Smith, Ernest S, Jonason, Alan, Reilly, Christine, Veeraraghavan, Janaki, Fisher, Terrence, Doherty, Michael, Klimatcheva, Ekaterina, Mallow, Crystal, Cornelius, Chad, Leonard, John E, Marchi, Nicola, Janigro, Damir, Argaw, Azeb Tadesse, Pham, Trinh, Seils, Jennifer, Bussler, Holm, Torno, Sebold, Kirk, Renee, Howell, Alan, Evans, Elizabeth E, Paris, Mark, Bowers, William J, John, Gareth, Zauderer, Maurice

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Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease von Southwell, Amber L, Franciosi, Sonia, Villanueva, Erika B, Xie, Yuanyun, Winter, Laurie A, Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hall, George, Pouladi, Mahmoud A, Smith, Ernest S, Bowers, William J, Zauderer, Maurice, Hayden, Michael R

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CXCL13 antibody for the treatment of autoimmune disorders von Klimatcheva, Ekaterina, Pandina, Tracy, Reilly, Christine, Torno, Sebold, Bussler, Holm, Scrivens, Maria, Jonason, Alan, Mallow, Crystal, Doherty, Michael, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

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Nonclinical Safety Evaluation of VX15/2503, a Humanized IgG4 Anti-SEMA4D Antibody von Leonard, John E, Fisher, Terrence L, Winter, Laurie A, Cornelius, Chad A, Reilly, Christine, Smith, Ernest S, Zauderer, Maurice

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A High-Affinity Fully Human Anti–IL-6 mAb, 1339, for the Treatment of Multiple Myeloma von FULCINITI, Mariateresa, HIDESHIMA, Teru, TAI, Yu-Tzu, TASSONE, Pierfrancesco, ANDERSON, Kenneth C, MUNSHI, Nikhil C, VERMOT-DESROCHES, Claudine, POZZI, Samantha, NANJAPPA, Puru, ZHENXIN SHEN, PATEL, Nipun, SMITH, Ernest S, WEI WANG, PRABHALA, Rao

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Use of poxvirus display to select antibodies specific for complex membrane antigens von Smith, Ernest S., Balch, Leslie A., Scrivens, Maria, Shi, Shuying, Wang, Wei, Harvey, Caroline D., Cornelison, Angelica A., Gil-Moore, Malgorzata, Kirk, Renee A., Mueller, Loretta L., Hall, Richard L., Howell, Alan P., Reilly, Christine A., Mayer, Jessica M., Murante, Francis G., Viggiani, Kari A, Gersz, Elaine M., Bussler, Holm, Keefe, Madeleine R., Evans, Elizabeth E., Paris, Mark J., Zauderer, Maurice

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Generation and preclinical characterization of an antibody specific for SEMA4D von Fisher, Terrence L, Reilly, Christine A, Winter, Laurie A, Pandina, Tracy, Jonason, Alan, Scrivens, Maria, Balch, Leslie, Bussler, Holm, Torno, Sebold, Seils, Jennifer, Mueller, Loretta, Huang, He, Klimatcheva, Ekaterina, Howell, Alan, Kirk, Renee, Evans, Elizabeth, Paris, Mark, Leonard, John E, Smith, Ernest S, Zauderer, Maurice

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Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D von Evans, Elizabeth E, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

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Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial von Feigin, Andrew, Evans, Elizabeth E., Fisher, Terrence L., Leonard, John E., Smith, Ernest S., Reader, Alisha, Mishra, Vikas, Manber, Richard, Walters, Kimberly A., Kowarski, Lisa, Oakes, David, Siemers, Eric, Kieburtz, Karl D., Zauderer, Maurice

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C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer von Evans, Elizabeth E, Henn, Alicia D, Jonason, Alan, Paris, Mark J, Schiffhauer, Linda M, Borrello, Melinda A, Smith, Ernest S, Sahasrabudhe, Deepak M, Zauderer, Maurice

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Publisher Correction: Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial von Feigin, Andrew, Evans, Elizabeth E., Fisher, Terrence L., Leonard, John E., Smith, Ernest S., Reader, Alisha, Mishra, Vikas, Manber, Richard, Walters, Kimberly A., Kowarski, Lisa, Oakes, David, Siemers, Eric, Kieburtz, Karl D., Zauderer, Maurice

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Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies von Evans, Elizabeth E, Jonason, Jr, Alan S, Bussler, Holm, Torno, Sebold, Veeraraghavan, Janaki, Reilly, Christine, Doherty, Michael A, Seils, Jennifer, Winter, Laurie A, Mallow, Crystal, Kirk, Renee, Howell, Alan, Giralico, Susan, Scrivens, Maria, Klimatcheva, Katya, Fisher, Terrence L, Bowers, William J, Paris, Mark, Smith, Ernest S, Zauderer, Maurice

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Abstract 4888: Antibody blockade of semaphorin 4D breaks down stromal barriers to enhance tumoricidal immune infiltration, supporting rational immunotherapy combinations von Evans, Elizabeth E., Bussler, Holm, Torno, Sebold, Mallow, Crystal, Reilly, Christine, Scrivens, Maria, Klimatcheva, Ekaterina, Winter, Laurie A., Kirk, Renee, Howell, Alan, Balch, Leslie, Leonard, John E., Paris, Mark, Fisher, Terrence L., Hu-Lieskovan, Siwen, Ribas, Antoni, Smith, Ernest S., Zauderer, Maurice

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A Vaccinia-based system for directed evolution of GPCRs in mammalian cells von Klenk, Christoph, Scrivens, Maria, Niederer, Anina, Shi, Shuying, Mueller, Loretta, Gersz, Elaine, Zauderer, Maurice, Smith, Ernest S, Strohner, Ralf, Plückthun, Andreas

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SEMA4D blocking antibody, pepinemab, is a novel potential treatment for neurodegenerative disease: Clinical proof of concept in Phase 2 HD study supports ongoing clinical developme... von Fisher, Terrence L, Evans, Elizabeth E, Boise, Megan, Foster, Amber, Mishra, Vikas, Mallow, Crystal L, Smith, Ernest S, Leonard, John E, Feigin, Andrew, Siemers, Eric, Walters, Kimberly, Sheldon, Elizabeth, Turner, Scott, Farlow, Martin R., Zauderer, Maurice

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Abstract A15: Integrated biomarker trials to evaluate myeloid and lymphoid composition of HNSCC and solid tumors treated with pepinemab and combinations with checkpoint inhibitors von Evans, Elizabeth E., Lesinski, Gregory B., Fisher, Terrence L., Mallow, Crystal, Olson, Brian, Clavijo, Paul E., Leonard, John E., Pastore, Desa Rae, Smith, Ernest S., Zauderer, Maurice, Allen, Clint T., Lowe, Michael, Kudchadkar, Ragini, Wu, Christina, Steuer, Conor, Saba, Nabil F.

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Lethality-based selection of recombinant genes in mammalian cells: Application to identifying tumor antigens von Zauderer, Maurice, Smith, Ernest S, Mandokhot, Aparna, Evans, Elizabeth E, Mueller, Loretta, Borrello, Melinda A, Sahasrabudhe, Deepak M

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Evidence that semaphorin 4D is upregulated in neurons in Huntington’s and Alzheimer’s diseases: Effects of a SEMA4D blocking antibody on FDG‐PET in a clinical trial, and treatment... von Evans, Elizabeth E., Fisher, Terrence L., Leonard, John E., Reader, Alisha M., Mishra, Vikas, Mallow, Crystal L., Balch, Leslie, Howell, Alan, Smith, Ernest S., Feigin, Andrew, Siemers, Eric R., Zauderer, Maurice

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