Potential mechanisms of resistance to venetoclax and strategies to circumvent it von Tahir, Stephen K, Smith, Morey L, Hessler, Paul, Rapp, Lisa Roberts, Idler, Kenneth B, Park, Chang H, Leverson, Joel D, Lam, Lloyd T

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets von Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W

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Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors von Phillips, Darren C., Buchanan, Fritz G., Cheng, Dong, Solomon, Larry R., Xiao, Yu, Xue, John, Tahir, Stephen K., Smith, Morey L., Zhang, Haichao, Widomski, Deborah, Abraham, Vivek C., Xu, Nan, Liu, Zhihong, Zhou, Li, DiGiammarino, Enrico, Lu, Xin, Rudra-Ganguly, Nandini, Trela, Bruce, Morgan-Lappe, Susan E.

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Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity von Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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Quantification of BCL-2 Family Members by Flow Cytometry von Smith, Morey L., Tahir, Stephen K.

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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity von Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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Development of a flow cytometric method for quantification of BCL‐2 family members in chronic lymphocytic leukemia and correlation with sensitivity to BCL‐2 family inhibitors von Smith, Morey L., Chyla, Brenda, McKeegan, Evelyn, Tahir, Stephen K.

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Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors von Tong, Yunsong, Florjancic, Alan S, Clark, Rick F, Lai, Chunqiu, Mastracchio, Anthony, Zhu, Gui-dong, Smith, Morey L, Kovar, Peter J, Shaw, Bailin, Albert, Daniel H, Qiu, Wei, Longenecker, Kenton L, Liu, Xiaoqin, Olson, Amanda M, Osterling, Donald J, Tahir, Stephen K, Phillips, Darren C, Leverson, Joel D, Souers, Andrew J, Penning, Thomas D

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Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity von Sleebs, Brad E, Czabotar, Peter E, Fairbrother, Wayne J, Fairlie, W. Douglas, Flygare, John A, Huang, David C. S, Kersten, Wilhelmus J. A, Koehler, Michael F. T, Lessene, Guillaume, Lowes, Kym, Parisot, John P, Smith, Brian J, Smith, Morey L, Souers, Andrew J, Street, Ian P, Yang, Hong, Baell, Jonathan B

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Discovery of A‑1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL‑XL Inhibitor von Wang, Le, Doherty, George A, Judd, Andrew S, Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R, Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R, Wang, Xilu, Wendt, Michael D, Flygare, John A, Catron, Nathaniel D, Judge, Russell A, Park, Chang H, Shekhar, Shashank, Phillips, Darren C, Nimmer, Paul, Smith, Morey L, Tahir, Stephen K, Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N, Mitten, Michael J, Boghaert, Erwin R, Gao, Wenqing, Kovar, Peter, Choo, Edna F, Diaz, Dolores, Fairbrother, Wayne J, Elmore, Steven W, Sampath, Deepak, Leverson, Joel D, Souers, Andrew James

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Correction to Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity von Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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Clearance of systemic hematologic tumors by venetoclax (Abt‐199) and navitoclax von Ackler, Scott, Oleksijew, Anatol, Chen, Jun, Chyla, Brenda J., Clarin, Jerry, Foster, Kelly, McGonigal, Thomas, Mishra, Sasmita, Schlessinger, Sally, Smith, Morey L., Tahir, Stephen K., Leverson, Joel D., Souers, Andrew J., Boghaert, Erwin R., Hickson, Jonathan

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Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression von Chen, Yung-Wu, Smith, Morey L, Sheets, Michael, Ballaron, Steve, Trevillyan, James M, Burke, Sandra E, Rosenberg, Teresa, Henry, Cindy, Wagner, Rolf, Bauch, Joy, Marsh, Kennan, Fey, Thomas A, Hsieh, Gin, Gauvin, Donna, Mollison, Karl W, Carter, George W, Djuric, Stevan W

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T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC von Haasch, Deanna, Chen, Yung-Wu, Reilly, Regina M, Grace Chiou, X, Koterski, Sandra, Smith, Morey L, Kroeger, Paul, McWeeny, Kerri, Halbert, Donald N, Mollison, Karl W, Djuric, Stevan W, Trevillyan, James M

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Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds von Trevillyan, James M., Chiou, X. Grace, Chen, Yung-Wu, Ballaron, Stephen J., Sheets, Michael P., Smith, Morey L., Wiedeman, Paul E., Warrior, Usha, Wilkins, Julie, Gubbins, Earl J., Gagne, Gerard D., Fagerland, Jane, Carter, George W., Luly, Jay R., Mollison, Karl W., Djuric, Stevan W.

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The Combinatorial Activity of Eftozanermin (ABBV-621), a Novel and Potent TRAIL Receptor Agonist Fusion Protein, in Pre-Clinical Models of Hematologic Malignancies von Smith, Morey L, Jin, Sha, Chen, Dong, Zhang, Haichao, Huska, Jason, Widomski, Deborah, Bontcheva, Vicky, Buchanan, Greg, Morgan-Lappe, Susan, Phillips, Darren C., Tahir, Stephen K

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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X-L Inhibitor von Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James

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Abbv-621 Is a Novel and Potent TRAIL Receptor Agonist Fusion Protein That Induces Apoptosis Alone and in Combination with Navitoclax and Venetoclax in Hematological Tumors von Tahir, Stephen Kenneth, Smith, Morey L, Solomon, Larry R, Zhang, Haichao, Xue, John C, Xiao, Yu, Cheng, Dong, Buchanan, Greg, Morgan-Lappe, Susan, Phillips, Darren C.

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Abstract B30: Mechanisms of resistance to ABT-199 in leukemia and lymphoma cell lines von Tahir, Stephen K., Smith, Morey L., Hessler, Paul, Roberts-Rapp, Lisa, Leverson, Joel D., Lam, Lloyd T.

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TH1 and TH2 cytokine inhibition by 3,5-bis(trifluoromethyl)pyrazoles, a novel class of immunomodulators von Chen, Yung-Wu, Smith, Morey L, Chiou, Grace X, Ballaron, Stephen, Sheets, Michael P, Gubbins, Earl, Warrior, Usha, Wilkins, Julie, Surowy, Carol, Nakane, Masaki, Carter, George W, Trevillyan, James M, Mollison, Karl, Djuric, Stevan W

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