Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’ von Schumacher, Felix F., Sanchania, Vishal A., Tolner, Berend, Wright, Zoë V. F., Ryan, Chris P., Smith, Mark E. B., Ward, John M., Caddick, Stephen, Kay, Christopher W. M., Aeppli, Gabriel, Chester, Kerry A., Baker, James R.

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A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy von Maruani, Antoine, Smith, Mark E.B., Miranda, Enrique, Chester, Kerry A., Chudasama, Vijay, Caddick, Stephen

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Directed evolution to re-adapt a co-evolved network within an enzyme von Strafford, John, Payongsri, Panwajee, Hibbert, Edward G., Morris, Phattaraporn, Batth, Sukhjeet S., Steadman, David, Smith, Mark E.B., Ward, John M., Hailes, Helen C., Dalby, Paul A.

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A colorimetric assay for screening transketolase activity von Smith, Mark E.B., Kaulmann, Ursula, Ward, John M., Hailes, Helen C.

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Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde von Hibbert, Edward G., Senussi, Tarik, Smith, Mark E.B., Costelloe, Sean J., Ward, John M., Hailes, Helen C., Dalby, Paul A.

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Directed evolution of transketolase activity on non-phosphorylated substrates von Hibbert, Edward G., Senussi, Tarik, Costelloe, Sean J., Lei, Wenling, Smith, Mark E.B., Ward, John M., Hailes, Helen C., Dalby, Paul A.

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Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation von Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F, Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A, Baker, James R, Smith, Mark E B, Caddick, Stephen

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Development of chemical probes: Toward the mode of action of a methylene-linked di(aryl acetate) E1 von Smith, Mark E.B., Gunn, Richard M., Rosivatz, Evelyn, Mak, Lok H., Woscholski, Rüdiger, Hailes, Helen C.

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Chemoenzymatic synthesis of PSGL-1 glycopeptides : Sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan von KOELLER, K. M, SMITH, M. E. B, WONG, C.-H

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novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK a... von Ho, Ka-Kei, Rosivatz, Evelyn, Gunn, Richard M, Smith, Mark E.B, Stavropoulou, Alexandra V, Rosivatz, Erika, Numbere, Macba G, Wong, John B, Lafitte, Valerie G.H, Behrendt, Jonathan M, Myatt, Stephen S, Hailes, Helen C, Woscholski, Rüdiger, Lam, Eric W.-F

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Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides von Smith, Mark E. B, Schumacher, Felix F, Ryan, Chris P, Tedaldi, Lauren M, Papaioannou, Danai, Waksman, Gabriel, Caddick, Stephen, Baker, James R

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Stereoselectivity of an ω-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one von Smithies, Kirsty, Smith, Mark E.B., Kaulmann, Ursula, Galman, James L., Ward, John M., Hailes, Helen C.

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Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate von Nathani, Ramiz, Moody, Paul, Smith, Mark E. B., Fitzmaurice, Richard J., Caddick, Stephen

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Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC) von Nunes, João P M, Morais, Maurício, Vassileva, Vessela, Robinson, Eifion, Rajkumar, Vineeth S, Smith, Mark E B, Pedley, R Barbara, Caddick, Stephen, Baker, James R, Chudasama, Vijay

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Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging von Schumacher, Felix F, Nunes, João P M, Maruani, Antoine, Chudasama, Vijay, Smith, Mark E B, Chester, Kerry A, Baker, James R, Caddick, Stephen

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Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis von Morais, Maurício, Nunes, João P M, Karu, Kersti, Forte, Nafsika, Benni, Irene, Smith, Mark E B, Caddick, Stephen, Chudasama, Vijay, Baker, James R

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Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis von Kaulmann, Ursula, Smithies, Kirsty, Smith, Mark E.B., Hailes, Helen C., Ward, John M.

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Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment von Bryden, Francesca, Maruani, Antoine, Savoie, Huguette, Chudasama, Vijay, Smith, Mark E. B, Caddick, Stephen, Boyle, Ross W

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Homogeneous Bispecifics by Disulfide Bridging von Hull, Elizabeth A, Livanos, Maria, Miranda, Enrique, Smith, Mark E. B, Chester, Kerry A, Baker, James R

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Pyridazinediones deliver potent, stable, targeted and efficacious antibody-drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody von Robinson, Eifion, Nunes, João P. M, Vassileva, Vessela, Maruani, Antoine, Nogueira, João C. F, Smith, Mark E. B, Pedley, R. Barbara, Caddick, Stephen, Baker, James R, Chudasama, Vijay

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