Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human von Basit, Abdul, Neradugomma, Naveen K, Wolford, Christopher, Fan, Peter W, Murray, Bernard, Takahashi, Ryan H, Khojasteh, S. Cyrus, Smith, Bill J, Heyward, Scott, Totah, Rheem A, Kelly, Edward J, Prasad, Bhagwat

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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells von Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P., Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P., Li, Li, Schultz, Brian E., Sakowicz, Roman, Smith, Bill J., Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y.

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Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine von Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P., Fan, Peter W., Murray, Bernard P., Takahashi, Ryan H., Khojasteh, S. Cyrus, Smith, Bill J., Thummel, Kenneth E., Prasad, Bhagwat

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Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches von Hosea, Natilie A., Collard, Wendy T., Cole, Susan, Maurer, Tristan S., Fang, Rick X., Jones, Hannah, Kakar, Shefali M., Nakai, Yasuhiro, Smith, Bill J., Webster, Rob, Beaumont, Kevin

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Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models von Yamazaki, Shinji, Vicini, Paolo, Shen, Zhongzhou, Zou, Helen Y, Lee, Joseph, Li, Qiuhua, Christensen, James G, Smith, Bill J, Shetty, Bhasker

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Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans von Smith, Bill J, Pithavala, Yazdi, Bu, Hai-Zhi, Kang, Ping, Hee, Brian, Deese, Alan J, Pool, William F, Klamerus, Karen J, Wu, Ellen Y, Dalvie, Deepak K

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Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model von Yamazaki, Shinji, Johnson, Theodore R, Smith, Bill J

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Characterization of Seasonal Pharmacokinetic Variability in Woodchucks von Zheng, Jim, Balsitis, Scott, Santos, Rex, Smith, Bill J., Subramanian, Raju

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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species von Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat

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18O‑Enabled High-Throughput Acyl Glucuronide Stability Assay von Yu, Zaikuan Josh, Le, Hoa, Tang, Jennifer, Yue, Qin, Zhang, Jingyu, Murray, Bernard, Liu, Xingrong, Smith, Bill J., Subramanian, Raju

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Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretrovira... von Subramanian, Raju, Tang, Jennifer, Zheng, Jim, Lu, Bing, Wang, Kelly, Yant, Stephen R, Stepan, George J, Mulato, Andrew, Yu, Helen, Schroeder, Scott, Shaik, Naveed, Singh, Renu, Wolckenhauer, Scott, Chester, Anne, Tse, Winston C, Chiu, Anna, Rhee, Martin, Cihlar, Tomas, Rowe, William, Smith, Bill J

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Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase von Dick, Ryan A., Liang, Xiaomin, Sun, Hailing, Murray, Bernard P., Smith, Bill J.

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Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism von Subash, Sandhya, Singh, Dilip K., Ahire, Deepak, Khojasteh, S. Cyrus, Murray, Bernard P., Zientek, Michael A., Jones, Robert S., Kulkarni, Priyanka, Zubair, Faizan, Smith, Bill J., Heyward, Scott, Leeder, J. Steven, Prasad, Bhagwat

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Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development von Zheng, Jim, Xin, Yan, Zhang, Jingyu, Subramanian, Raju, Murray, Bernard P, Whitney, J Andrew, Warr, Matthew R, Ling, John, Moorehead, Lisa, Kwan, Ellen, Hemenway, Jeffrey, Smith, Bill J, Silverman, Jeffrey A

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Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs von Subash, Sandhya, Singh, Dilip K, Ahire, Deepak S, Khojasteh, S Cyrus, Murray, Bernard P, Zientek, Michael A, Jones, Robert S, Kulkarni, Priyanka, Smith, Bill J, Heyward, Scott, Cronin, Ciarán N, Prasad, Bhagwat

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Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection von Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.

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Application of target-mediated drug disposition model to small molecule heat shock protein 90 inhibitors von Yamazaki, Shinji, Shen, Zhongzhou, Jiang, Ying, Smith, Bill J, Vicini, Paolo

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In Vitro Kinetic Characterization of Axitinib Metabolism von Zientek, Michael A, Goosen, Theunis C, Tseng, Elaine, Lin, Jian, Bauman, Jonathan N, Walker, Gregory S, Kang, Ping, Jiang, Ying, Freiwald, Sascha, Neul, David, Smith, Bill J

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In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: implications for disposition and drug interactions von Reyner, Eric L, Sevidal, Samantha, West, Mark A, Clouser-Roche, Andrea, Freiwald, Sascha, Fenner, Katherine, Ullah, Mohammed, Lee, Caroline A, Smith, Bill J

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An industrial perspective on contemporary applications of PBPK models in drug discovery and development von Smith, Bill J.

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